The lost managemnts Flashcards
DIC ix and mx
A typical blood picture includes:
↓ platelets
↓ fibrinogen
↑ PT & APTT
↑ fibrinogen degradation products
schistocytes due to microangiopathic haemolytic anaemia
Fresh frozen plasma (FFP) is the preferred agent for replacement of coagulation factors and coagulation inhibitors when significant bleeding is present
Replace platelets below 20
Shock meds
Cardiac output down, Peripheral resistance UP–Cardiogenic, Hypovalemic (heamorraghe)
Give IV fluids-Crystalloids (eg Hartmans)
IF NOT BLEEDING—–Use an inotrope (e.g., dobutamine) if there is impaired cardiac function.
Non volume responsive- vasopressors are Norepinephrine
Distributive (sepsis, neuro, Anaphylaxis)
Vasopressors–Noradrenaline/Norepinephrine
Head injury CT Guidelines
CT head within 1 hour
GCS < 13 on initial assessment
GCS < 15 at 2 hours post-injury
suspected open or depressed skull fracture
any sign of basal skull fracture (haemotympanum, ‘panda’ eyes, cerebrospinal fluid leakage from the ear or nose, Battle’s sign).
post-traumatic seizure.
focal neurological deficit.
more than 1 episode of vomiting
CT head scan within 8 hours of the head injury - for adults with any of the following risk factors who have experienced some loss of consciousness or amnesia since the injury:
age 65 years or older
any history of bleeding or clotting disorders including anticogulants
dangerous mechanism of injury (a pedestrian or cyclist struck by a motor vehicle, an occupant ejected from a motor vehicle or a fall from a height of greater than 1 metre or 5 stairs)
more than 30 minutes’ retrograde amnesia of events immediately before the head injury
If a patient is on warfarin who have sustained a head injury with no other indications for a CT head scan, perform a CT head scan within 8 hours of the injury.
Head injury -types of injury
Subdural- banana/cresent shaped-Bridging VEINS–Risk factors include old age, alcoholism and anticoagulation.
Slower onset of symptoms than a epidural haematoma. There may be fluctuating confusion/consciousness
Epidural/extradural–lens shaped–
The majority of epidural haematomas occur in the temporal region where skull fractures cause a rupture of the middle meningeal ARTERY
features of raised intracranial pressure
some patients may exhibit a lucid interval
SAH-Classically causes a sudden occipital headache. Usually occurs spontaneously in the context of a ruptured cerebral aneurysm but may be seen in association with other injuries when a patient has sustained a traumatic brain injury
Intracerebral Bleed–
intracerebral (or intraparenchymal) haemorrhage is a collection of blood within the substance of the brain.
Causes / risk factors include: hypertension, vascular lesion (e.g. aneurysm or arteriovenous malformation), cerebral amyloid angiopathy, trauma, brain tumour or infarct (particularly in stroke patients undergoing thrombolysis).
Patients will present similarly to an ischaemic stroke (which is why it is crucial to obtain a CT in head in all stroke patients prior to thrombolysis) or with a decrease in consciousness.
Diffuse axonal injury occurs as a result of mechanical shearing following deceleration, causing disruption and tearing of axons
The Cushings reflex (hypertension and bradycardia) often occurs late and is usually a pre terminal event
Head injury pupil signs
Unilaterally dilated -light reflex -Sluggish or fixed—-3rd nerve compression secondary to tentorial herniation
Bilaterally dilated–light refle–Sluggish or fixed
=>Poor CNS perfusion or Bilateral 3rd nerve palsy
Unilaterally dilated or equal
light reflex–Cross reactive (Marcus - Gunn)
=Optic nerve injury
Bilaterally constricted –light reflex–May be difficult to assess
Opiates
Pontine lesions
Metabolic encephalopathy
Unilaterally constricted–light reflex–Preserved—Sympathetic pathway disruption
Head injury management
The Cushings reflex (hypertension and bradycardia) often occurs late and is usually a pre terminal event -need to manage head injury
whilst theatre is prepared or transfer arranged use of IV mannitol/ frusemide may be required –for raised ICP
ICP monitor and intubate if GCS <8
Minimum of cerebral perfusion pressure of 70mmHg in adults
SIADH common cause of hyponatremia
rarely/last resort–decompressive craniotomy/craniectomy
Neuroleptic malignant syndrome management
pyrexia
muscle rigidity
autonomic lability: typical features include hypertension, tachycardia and tachypnoea
agitated delirium with confusion
REFLEXES DOWN
A raised creatine kinase is present in most cases.
Acute kidney injury (secondary to rhabdomyolysis) may develop in severe cases. A leukocytosis may also be seen
Mx–
stop antipsychotic
IV fluids to prevent renal failure
dantrolene may be useful in selected cases
bromocriptine, dopamine agonist, may also be used
Opioid missuse mx
Iv/IM naloxone is mx
Longer term-#
harm reduce with clean needles
Methadone/buponeprhine for longer term
compliance is monitored using urinalysis
detoxification should normally last up to 4 weeks in an inpatient/residential setting and up to 12 weeks in the community
Trigeminal Neuralgia mx
Trigeminal neuralgia is a pain syndrome characterised by severe unilateral pain. The vast majority of cases are idiopathic
a unilateral disorder characterised by brief electric shock-like pains, abrupt in onset and termination, limited to one or more divisions of the trigeminal nerve
red flag symptoms -urgent refer to neuro
Management
carbamazepine is first-line
failure to respond to treatment or atypical features (e.g. < 50 years old) should prompt referral to neurology
Parkinsons and parkinsonisms mx
Most Parkinsonisms–
if the motor symptoms are affecting the patient’s quality of life: levodopa
–/second line—not affecting the patient’s quality of life: dopamine agonist (non-ergot derived), levodopa or monoamine oxidase B (MAO‑B) inhibitor
always make sure to avoid- haloperidol/domperidone
if need to tranquilise– use short acting BDZ like lorazepam
CAREFUL- Lewy body is treated more like ALZHEIMERS
neuroleptics should be avoided in Lewy body dementia as patients are extremely sensitive and may develop irreversible parkinsonism. Questions may give a history of a patient who has deteriorated following the introduction of an antipsychotic agent
Alhzheimers mx
The three acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) as options for managing mild to moderate Alzheimer’s disease
memantine (an NMDA receptor antagonist) ‘second-line’ treatment for Alzheimer’s
Donepezil
is relatively contraindicated in patients with bradycardia
Frontotemporal dementia (Pick’s disease) mx
young onset –personality change and impaired social conduct. Other common features include hyperorality, disinhibition, increased appetite, and perseveration behaviours.
Management
NICE do not recommend that AChE inhibitors or memantine are used in people with frontotemporal dementia
none sepcific
vascular dementia mx
Step down degrdation in vasculopath
There is no specific pharmacological treatment approved for cognitive symptoms
Only consider AChE inhibitors or memantine for people with vascular dementia if they have suspected comorbid Alzheimer’s disease, Parkinson’s disease dementia or dementia with Lewy bodies.
vascular dementia mx
Step down degrdation in vasculopath
There is no specific pharmacological treatment approved for cognitive symptoms
Only consider AChE inhibitors or memantine for people with vascular dementia if they have suspected comorbid Alzheimer’s disease, Parkinson’s disease dementia or dementia with Lewy bodies.
AAA ix and mx
1 USS at 65–
<3cm-nada
3-4.5-screen every year
4.5-5.5-screen every 3m
>5.5 or growing >1cm per year- operate
treat with elective endovascular repair (EVAR) or open repair if unsuitable. In EVAR a stent is placed into the abdominal aorta via the femoral artery to prevent blood from collecting in the aneurysm. A complication of EVAR is an endo-leak, where the stent fails to exclude blood from the aneurysm, and usually presents without symptoms on routine follow-up.
Aortic stenosis mx
Management
if asymptomatic then observe the patient is a general rule
if symptomatic then valve replacement
if asymptomatic but valvular gradient > 40 mmHg and with features such as left ventricular systolic dysfunction then consider surgery
options for aortic valve replacement (AVR) include:
surgical AVR is the treatment of choice for young, low/medium operative risk patients. Cardiovascular disease may coexist. For this reason, an angiogram is often done prior to surgery so that the procedures can be combined
transcatheter AVR (TAVR) is used for patients with a high operative risk
balloon valvuloplasty
unstable
may be used in children with no aortic valve calcification
in adults limited to patients with critical aortic stenosis who are not fit for valve replacement
Mitrial stenosis Mx
patients with associated atrial fibrillation require anticoagulation
currently warfarin is still recommended for patients with moderate/severe MS
DOACs
A diuretic may reduce left atrial pressure and relieve mild symptoms, although diuretic therapy alone is rarely adequate to relieve symptoms
asymptomatic patients
monitored with regular echocardiograms
percutaneous/surgical management is generally not recommended
symptomatic patients
percutaneous mitral balloon valvotomy
mitral valve surgery (commissurotomy, or valve replacement)
pregnant-diuretics and baloon valvotomy
Aortic Regurg mx
Management
medical management of any associated heart failure
surgery: aortic valve indications include
symptomatic patients with severe AR
asymptomatic patients with severe AR who have LV systolic dysfunc
acute–ionotrope, vasopressor and urgent valve replace
if very symptomatic–Open heart
TAVI rarely done
Mitrial Regurg Mx
Medical management in acute cases involves nitrates, diuretics, positive inotropes and an intra-aortic balloon pump to increase cardiac output
If patients are in heart failure, ACE inhibitors may be considered along with beta-blockers and spironolactone
In acute, severe regurgitation, surgery is indicated
The evidence for repair over replacement is strong in degenerative regurgitation, and is demonstrated through lower mortality and higher survival rates
When this is not possible, valve replacement with either an artificial valve or a pig valve is considered
Arterial ulcer mx
Occur on the toes and heel
Painful
There may be areas of gangrene
Cold with no palpable pulses
Low ABPI measurements
surgery to reopen vessels
Venous ulcer mx
Most due to venous hypertension, secondary to chronic venous insufficiency
Features of venous insufficiency include oedema, brown pigmentation, lipodermatosclerosis, eczema
Location above the ankle, painless
Deep venous insufficiency is related to previous DVT and superficial venous insufficiency is associated with varicose veins
Doppler ultrasound looks for presence of reflux and duplex ultrasound looks at the anatomy/ flow of the vein
Management: 4 layer compression banding after exclusion of arterial disease or surgery
If fail to heal after 12 weeks or >10cm2 skin grafting may be needed
Gangrene ix/mx
Type 1 is caused by mixed anaerobes and aerobes (often occurs post-surgery in diabetics). This is the most common type (multibacterial)
type 2 is caused by Streptococcus pyogenes (monobacterial)-can use hyperbaric ox
Gram stain of infected tissue may demonstrate gram-positive bacilli
acute onset
pain, swelling, erythema at the affected site
often presents as rapidly worsening cellulitis with pain out of keeping with physical features
extremely tender over infected tissue with hypoaesthesia to light touch
skin necrosis and crepitus/gas gangrene are late signs
fever and tachycardia may be absent or occur late in the presentation
need emergency fascitomy and abx
ischemic gangrene-acute limb- heparin and surgery
WPW mx
short PR interval
wide QRS complexes with a slurred upstroke - ‘delta wave’
left axis deviation if right-sided accessory pathway
in the majority of cases, or in a question without qualification, Wolff-Parkinson-White syndrome is associated with left axis deviation
right axis deviation if left-sided accessory pathway
definitive treatment: radiofrequency ablation of the accessory pathway
medical therapy: sotalol***, amiodarone, flecainide
sotalol should be avoided if there is coexistent atrial fibrillation
Tricuspid regurg mx
Operation should be considered for medically refractory right heart failure, imminent or existing atrial fibrillation, or progressive right ventricular dilation and dysfunction. –Symtomatic
annuloplasty or valve repair
HF mx needed
