The Liver Flashcards
What is a hepatocytes?
A liver cell
Why is it essential for good blood supply in liver?
Very metabolically active cells, important role in homeostasis - metabolism reaction generate heat, maintain glucose levels
Which sources supply liver with blood?
Oxygenated blood from the heart, oxygen for aerobic respiration, very active. From hepatic artery
Deoxygenated blood from digestive system, through hepatic portal vein, rich in products of digestion, uncontrolled concentrations, may be toxic
What is the hepatic portal vein?
Unusual blood vessel that has capillaries at both ends, carries blood from digestive system to the liver, products uncontrolled concentration so removal of excess amino acids, glucose, alcohol etc
What vessel does blood leave liver from?
Hepatic vein that rejoins the vena cava
What is the fourth vessel in the liver?
Bile duct, bike secretes from liver cells into bile duct, carries it to gall bladder where it is stored to be used to digest fats in the small intestines
How are cells in the liver arranged?
Arranged to ensure maximum contact with blood, divided into lobes, further divided into lobules, hepatic vein and portal vein enter liver, split into small vessels, inter lobular. At intervals, branch off and enter lobules, blood mixed, and passes into sinusoid, lined with liver cells. Sinusoid empties into the intralobular vessel, branch of hepatic vein, branches join together to form hepatic vein, drains blood from the liver
What is the role of the sinusoid?
Runs through lobules, ensures blood comes into close contact with liver cells, so they can remove and pass molecules into the blood
How is bile moved through the liver?
Manufacture bile, released into bile canaliculi, join together to form bile duct, which transports bile to gall bladder
Outline passage of blood through liver
Hepatic portal vein and hepatic artery bring blood in, split into inter lobular vessels, branch and enter lobules, into sinusoid, drains into intra lobular vessel, join to form hepatic vein to drain out if liver
How are liver cells specialised?
Hepatocytes, cuboidal, micro villi to increase SA, many metabolic functions, so cytoplasm is very dense, specialised in amounts of organelles
What are the metabolic functions of the liver?
Protein synthesis Carbohydrate storage Protein synthesis Cholesterol synthesis Bike salts Detoxification
What are kupffer cells?
Specialised macrophages that move in sinusoids and involved in breakdown of old red blood cells, bilirubin produced haemoglobin break down, rexcreted in bile and faeces
What are the functions of the liver?
Control of blood glucose, amino acids, lipid levels
Synthesis of red blood cells in fetid, bile, plasma proteins, cholesterol
Storage of vitamins and glycogen
Detoxification if alcohol and drugs
Breakdown of hormones
Destruction of red blood cells
What is urea?
Excretory product formed from the breakdown of excess amino acids