The Learning topic- Pathology (Non-neoplastic diseases of bone)

Question 1

where is woven bone normally found

Answer 1

fetus

Question 2

what is the progenitor of osteoblasts

Answer 2

osteoprogenitor cells

Question 3

what is the progenitor of osteoclasts

Answer 3

monocytes-macrophages

Question 4

what type of inheritance is achondroplasia, also, what chromosome

Answer 4

autosomal dominant

short arm of 4 (4p)

Question 5

what mutation is found in achondroplasia

Answer 5

fibroblast growth factor receptor 3 gene

Question 6

defective synthesis of what leads to osteogenesis imperfecta

Answer 6

type 1 collagen

Question 7

what is the underlying cause of osteopetrosis

Answer 7

defect in function of osteoclasts

Question 8

what is the characteristic of osteopetrosis
a- small yet strong bones 
b- massive yet fragile bones 
c- small yet fragile bones 
d- massive yet strong bones

Answer 8

b-massive yet fragile bones

Question 9

what are the primary cases of osteoporosis

Answer 9

senile

postmenopausal

Question 10

what is the histological pattern of pagets disease

Answer 10

mosaic pattern

Question 11

what is the underlying causes of rickets/osteomalacia

Answer 11

lack of vitamin D

Question 12

what is the underlying causes of hyperparathyroidism

Answer 12

increased parathyroid hormone so MORE osteoclastic activity

Question 13

what is the most common site for osteonecrosis

Answer 13

femoral head!