The Immune System: Pathogens, Infection and Defenses Flashcards

1
Q

What is a pathogen?

A

An agent that potentially infects and damages host cells.

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2
Q

What are examples of potential agents within infectious diseases, in order of size/complexity?

A
  • Prions: Non-living, but have life-like properties
  • Viruses
  • Bacteria
  • Protists
  • Fungi: Eukaryotes, multicellular
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3
Q

Most pathogens are very _____________ in the ability to infect different species.

A

Restricted/narrow –> Pathogenesis is host-specific

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4
Q

What is virulence?

A

The degree of damage to the host (or mortality rate in a population) associated with a pathogen.

= Level of harm

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5
Q

What is transmission?

A

The transfer of a pathogen/agent from one individual organism to another = Spread of the disease

In multicellular organisms, we consider this as from an individual to another.

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6
Q

What are common means of transmission?

A
  • Contact with the infected individual
  • Droplets (fluids)
  • Airborne transmission
  • Vector (mosquitoes)
  • Common vehicles (syringes)
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7
Q

What does the seriousness/impact of a disease depend upon?

A
  • Rate of transmission
  • Virulence
  • Number of susceptibles
  • Host recovery rate

NOT all hosts are susceptible.

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8
Q

Epidemiological parameters are all influenced by…

A

The immune system!

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9
Q

What is the role of the immune system?

A

It recognizes foreign bodies and responds with the production of immune cells and proteins.

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10
Q

All animals exhibit some _______ immunity.

A

Innate = Built-in, born with this

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11
Q

A subset of animals, vertebrates, also exhibit _____________.

A

Acquired immunity –> “Memory” in the immune system

Depends on previous exposure

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12
Q

What is innate immunity?

A
  • Present before any exposure to pathogens
  • Effective from the time of birth
  • Involves nonspecific responses to a broad range of pathogens

**Fixed for lifetime

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13
Q

What are examples of innate immunity?

A

External barriers;

Internal cellular and chemical defences.

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14
Q

What is acquired immunity?

A
  • Develops after exposure to agents such as microbes, toxins, or other foreign substances
  • Involves a very specific response to pathogens

**‘Learned’ response

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15
Q

What are examples of acquired immunity?

A

Antibodies;
“Memory cells” (lymphocytes)

**Veterans of a previous exposure

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16
Q

From which mechanisms does innate immunity arise?

A
  • Barrier defences
  • Antimicrobial peptides (AMPs) –> Chemical weapons
  • Cellular innate defences
17
Q

From which mechanisms does acquired immunity arise?

A
  • Humoral immune response

- Cell-mediated acquired response

18
Q

______________ serve as an example for the basic animal immune system, with no acquired immunity.

A

Invertebrates.

Example: Cordyceps fungi results in ‘zombie ants’

19
Q

What is epidemiology?

A

The study of the spread of infectious diseases.

20
Q

What is a synonymous definition to acquired immunity?

A

Adaptive immunity

21
Q

Innate immunity: Barrier defenses

A
  • Includes skin/exoskeleton and mucous membranes (epithelium)
  • Mucus traps and allows for the removal of microbes
  • Many body fluids, including saliva, mucus, and tears, are hostile to many microbes
22
Q

What factor of mammalian skin and the digestive system prevent growth of many bacteria?

A

Low pH

23
Q

What is phagocytosis?

A

In all animals, the primary means of dealing with foreign substances, including dead cell debris, pathogens, etc.

-Cells eating other things

= Innate immunity, CELLULAR elements

-Engulfing things at a more mechanistic level

24
Q

What are haemocytes?

A

In invertebrates, a class of patrolling cells that perform phagocytosis, “eating”/engulf foreign particles/cells

-Free-floating in insects

25
Q

How does the phagocytosis process work?

A
  1. Patrol in bloodstream, tissue, lymph of an insect
  2. Encounter something foreign
  3. Engulf the foreign substance, neutralize them
  4. Store the foreign entity in a vacuole, targeted for destruction using a lysosome
26
Q

What are anti-microbial peptides?

A

Free-floating explosive mines in the lymph of insects, contained within the haemolymph.

Disrupts ‘compatible’ cell walls, membranes of fungi, bacteria and protists.

Built-in chemical defence.

NB. They are FIXED throughout lifetime, innately present in the lymph of insects

27
Q

How do patrolling cells recognize foreign bodies?

A

TOLL-LIKE RECEPTORS (TLRs).

Located on the surface of the patrolling cells, on the cell membrane –> Detect different pathogens/foreign bodies, facilitating recognition and thus engulfing.

28
Q

What is the key to many cellular defences in vertebrates?

A

LEUKOCYTES, white blood cells.

Many are part of the innate immune defense
-Patrolling monocytes

Another class within leukocytes is LYMPHOCYTES, central to the acquired immune defence.

29
Q

What can the lymphatic system be compared to?

A

A highway system to move leukocytes around the body, storing and permitting the maturation/development of these cells.

30
Q

Where do white blood cells typically come from, developmentally?

A

From stem cells in bone marrow.

They generate two main classes of WBC, lymphoids and myeloids.

Myeloid stem cells –> Erythocytes, neutrophils, basophils, monocytes, platelets, eosinophils

Lymphoid stem cells –> B cells and T cells (lymphocytes)

31
Q

What are the two main types of phagocytic cells in vertebrate animals?

A
  1. MONOCYTES: Group of cellular defenders, such as macrophages, that patrol the tissues/blood, engulf pathogens, signal/initiate the immune response

“Security guards”, call in reinforcement when needed.

  1. NEUTROPHILS: Arrive afterwards to engulf and destroy pathogens

“Reinforcement, back-up team”

32
Q

What other cellular innate defenders exist?

A
  • EOSINOPHILS: Release pathogen-destroying enzymes, specialize on multicellular parasites
  • NATURAL KILLER CELLS: Detect/destroy abnormal cells by chemical means –> Detonate them
  • DENDRITIC CELLS (a second type of monocytes): Messengers stimulated the cells in the acquired immune system.
33
Q

What family of proteins is specific to vertebrate immune systems?

A

INTERFERONS: They are laid chemical traps, providing innate defense, especially interfering with VIRUSES and helping activate other cells involved in immunity

34
Q

What is the complement system?

A

A series of specialized proteins, which cause lysis of invading cells, and helping trigger inflammation.

35
Q

How can pathogens avoid destruction?

A
  • Protective coatings on their cell walls
  • Modifying surface to avoid recognition

=Counter-weapons, evolution!

-Tolerating lysozyme activity: Even after being broken down following phagocytosis!

36
Q

Are the abilities to avoid host immune systems in most viruses/bacteria innate?

A

YES! They are fixed in a manner analogous to innate immunity of the host = Genetically determine strain.