The Future of Genomics

Question 1

What is the advantage of genomic data in inherited predisposition to disease?

Answer 1

We can use genomic data to
–Diagnose a rare genetic condition
• Explain why a person developed this condition
• Give advice on prognosis
• Help with management
–Help us predict whether a person is more likely to
develop a common condition and offer screening,
prevention, early detection

Question 2

What is the definition of pharmacogenomics?

Answer 2

Pharmacogenomics: using genomic data to get the right drug to the right patient at the right time
This can enable us to target treatment at the biological pathways underlying the condition

Question 3

How do PARP inhibitors work?

Answer 3

They are a targeted cancer therapy that works by inhibiting an enzyme in cells called “PARP” which plays a key role in DNA repair.
Blocking PARP helps in preventing cancerous cells from repairing their damaged DNA, so killing them

Question 4

What is gene therapy?

Answer 4

The delivery of DNA or RNA into a patient’s cells as a drug to treat disease, including the replacement of a mutated gene with functional copy.