The Corticohippocampal Circuit: Order Flashcards

1
Q

declarative memory

A

conscious, goal directed encoding and recall of information

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2
Q

semantic memory

A

encoding and recall of general facts (i.e. encyclopaedic knowledge)

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3
Q

episodic memory

A

encoding and recall of specific facts related to our unique experiences

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4
Q

STUDY: remember faces

A

encoding: learn name
distractor: odd/ even number task
recall: asking if correct name stem

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5
Q

what faces study showed about encoding

A

associated with activation of entire HF

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6
Q

what was point of distractor?

A

to make sure its not just in working memory

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7
Q

what did faces study show about recall?

A

HF activation

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8
Q

STUDY: visual one-to-one connections

A

(used depth electores in hippocampi and had participants look at visuals)
- “Jennifer Aniston neuron” spike in neuron when see picture of her
- “Halle Berry neuron” spike in different neuron, also responded to letter string of her name

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9
Q

long-term potentiation

A

increases strength of connection between neurons supporting memory (ex. begin to remember name with face, apartment they live in, etc.)

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10
Q

how does electical stimulation of the hippocampus impact memory consolidation?

A

variety of studies
- one shows greater memory of word pairs
- sometimes can hurt memory consolidation

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11
Q

semantic map in the human brain

A

stored in the cortex

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12
Q

relationship between memory stories and consolidation

A

hippocampus important for remembering and encoding but meaning is stored in the cortex

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13
Q

what stream

A
  1. encoding and recall
  2. PRC –> LEC (item) encoding and recall
  3. hippocampus (item in context)
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14
Q

where stream

A
  1. cortical areas encoding and recall
  2. PHC –> MEC (context) encoding and recall
  3. hippocampus (item in context)
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15
Q

emotional “flashbulb memories”

A

convergence of strong happiness and reward of fear and threat

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16
Q

where is object memory stored?

A

anterior hippocampus

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17
Q

where is spatial memory stored?

A

posterior hippocampus

18
Q

what is a good metaphor for hippocampus?

A

card catalog, it stores where you can locate the book in the library, but does not store books itself
(ex. visual memories in visual cortices)

19
Q

what is directed encoding with the PFC?

A

executive control (ex. learn names of these faces) (ex. mentally rehearsing material before an exam)

20
Q

what is executive control?

A

capacity to generate and orchestrate complex plans and goal-directed behaviors through…

21
Q

what is attention?

A

selectively concentrating on one aspect of stimulus

22
Q

what is working memory?

A

briefly maintaining infornation in mind and manipulating it to achieve goals

23
Q

what is response selection?

A

direct and redirect behavioral resources because of changing demands

24
Q

STUDY: wisconsin card sorting test

A

(had to sort cards and then sort in different way until given positive feedback)
EXECUTIVE CONTROL

25
Q

STUDY: CPT (Connor’s continuous performance task)

A

(information quickly on screen, have to press button when target letter appears) how long can you maintain attention?
ATTENTION & RESPONSE SELECTION

26
Q

STUDY: N-back test

A

(press button when letter shown n-back from front) used fMRI
WORKING MEMORY

27
Q

STUDY: stroop task

A

(showing color words in same/ different color ink, identify ink color) slower bc incongrunt trial, read word first
RESPONSE SELECTION

28
Q

what activates when maintaining information in working memory?

A

dACC (negative error feedback), dlPFC, vlPFC, parietal cortex

29
Q

what is TMS?

A

transcranial magnetic stimulation
can impair or inhibit activity useful for cortical circuits

30
Q

STUDY: faces and spot

A

(show spot in 3 locations, show pic of spot and ask if saw location, then show face and ask if seen the face before)
RESULTS:
1. location impaired when TMS on dmPFC
2. faces impaired when TMS on vlPFC
3. both impaired when TMS on dlPFC

31
Q

why faces impaired by vlPFC impaired?
why location impaired by dmPFC impaired?

A

dorsal(where) and ventral(what) stream

32
Q

how do pyramidal and GABA neurons interact in stroop test?

A

when doing stroop test, pyramidal neurons processing ink color inhibit those processing word with GABA neurons

33
Q

STUDY: understanding anatomy of stroop test

A
  • afferent layers (IV) info change processing in dlPFC
  • efferent layers (V + VI) dlPFC regulates subcortical regions
34
Q

how can we reinforce inhibition of reading word in stroop test?

A
  • release of dopamine, reward (increases cholinergic signaling)
  • amygdala, can punish incorrect response (NBM, cholinergic tone)
35
Q

what does the medial frontopolar cortex do?

A

undirected exploration
- monitors current goal for redistributing cognitive resources for another potential goal

36
Q

what does the lateral frontopolar cortex do?

A

directed exploration
- monitoring a few alternative tasks/ goals for possibly re-engaging one as replacement of the current task/ goal

37
Q

what does the posterior prefrontal cortex do?

A

exploitation
- recruiting and implementing cognitive control to optimize the performance of the current goal

38
Q

what are the afferent layers of the dlPFC?

A

layers I-III
- mediate cholinergic potentiation of dlPFC through NBM (corticolimbic) or VP (corticostriatal)

39
Q

what are the efferent layers of the dlPFC?

A

layers V & VI
- allow dlPFC to regulate VS and HF

40
Q
A