The Complement System Flashcards

1
Q

What is the main function of the complement system?

A

To enhance the ability of antibodies and phagocytic cells to clear pathogens.

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2
Q

True or False: The complement system is part of the innate immune system.

A

True

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3
Q

Fill in the blank: The complement system consists of over ____ proteins.

A

30

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4
Q

Which pathway of the complement system is activated by antibodies binding to antigens?

A

Classical pathway

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5
Q

What is the main enzyme involved in the complement system activation?

A

C3 convertase

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6
Q

Which complement protein is known for its ability to form membrane attack complexes?

A

C9

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7
Q

What is the name of the process where complement proteins coat the surface of pathogens to facilitate their recognition and destruction?

A

Opsonization

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8
Q

Which complement protein is responsible for the chemotaxis of immune cells to the site of infection?

A

C5a

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9
Q

True or False: The complement system can cause inflammation.

A

True

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10
Q

What is the role of the alternative pathway in the complement system?

A

To provide a rapid response to pathogens before antibodies are produced.

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11
Q

Which complement protein acts as a bridge between the innate and adaptive immune responses?

A

C3

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12
Q

What is the name of the process where the complement system helps to clear immune complexes and apoptotic cells?

A

C3b-mediated clearance

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13
Q

Fill in the blank: The complement system plays a crucial role in the defense against ____ infections.

A

bacterial

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14
Q

Which complement protein is involved in the formation of the membrane attack complex?

A

C6

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15
Q

True or False: Deficiencies in the complement system can lead to autoimmune diseases.

A

True

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16
Q

What is the name of the process where the complement system helps to regulate the immune response and prevent excessive inflammation?

A

Regulation of complement activation

17
Q

Which complement protein is involved in the classical pathway and binds to antibodies?

A

C1q

18
Q

True or False: The complement system can be activated by both antibody-dependent and antibody-independent mechanisms.

A

True

19
Q

What is the role of the lectin pathway in the complement system?

A

To recognize and bind to specific sugar patterns on pathogens.

20
Q

Which complement protein acts as an opsonin to facilitate phagocytosis?

A

C3b

21
Q

Fill in the blank: The complement system can enhance the killing of pathogens by ____.

A

phagocytes

22
Q

What is the main function of the membrane attack complex?

A

To create pores in the pathogen’s membrane, leading to cell lysis.

23
Q

Which complement protein is involved in the lectin pathway and binds to carbohydrates on pathogens?

A

MBL (Mannose-binding lectin)

24
Q

True or False: The complement system can contribute to the pathogenesis of certain diseases.

A

True