The Child with an Infectious Disease Flashcards
Disease Process
?
Time interval between initial infection and 1st appearance of signs and symptoms
Incubation period
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Early, mild symptoms of disease
Prodromal period
Period of Illness
* Overt signs and symptoms of disease
* WBC may increase or decrease
* Death may result if immune system or treatment fails
Period of Decline
* Signs and symptoms subside
* Vulnerable to secondary infections
Period of convalescence
* Regains strength and body returns to pre-disease state
* Recovery has occurred
Chain of Infection
* For a pathogen to maintain an infectious state it needs to be transmitted to another host
* To spread the infection, the pathogen must follow the chain of infection
Agent > Reservoir > Portal of exit > Transmission mode > Portal of entry > Host susceptibility >
Characteristics of the Organism (Pathogen)
- Type (viruses, bacteria, fungi, parasites)
- Ability to invade host
- Virulence
- Degree to which it causes disease
Portal of Entry
- Eyes
- Mucus membranes
- Respiratory tract
- Placenta
- Breaks in host barriers
Reservoir
- Humans
- Animals
- Environmental surfaces
Portal of exit
- Respiratory tract
- Genitourinary tract
- Gastrointestinal tract
- Skin/mucosal surfaces
- Placenta
- Blood
Mode of Transmission
- Direct contact
- Droplets
- Vectors
- Airborne
Characteristics of the Host
- Lack of effective resistance
- Changes in host defenses
- Tissue destruction
Viral Infections
Viruses
* Small parasitic organisms
* One type of DNA or RNA
* Lack reproductive ability - need host
* Infected host can respond to that viral invasion
- Lysis
- Continue functioning (asymptomatic)
* May remain dormant until triggered
* Rubeola (“ordinary” measles, 7-day)
* Rubella (German measles, 3-day)
* Erythema infectiosum (“Fifth Disease”, Parvovirus B19)
* Roseola Infantum (Exanthem Subitum, 3-day fever)
* Coxsackievirus A (hand-foot-mouth)
* Varicella zoster infections (chickenpox, shingles)
* Mumps
* Cytomegalovirus (CMV)
* Infectious mononucleosis (EBV)
* Rabies
Viral Exanthemas (Rashes)
Rubeola (Measles) - “7-day Measles”
* Causative agent: RNA virus
* Incubation: 8-12 days from exposure to onset of symptoms
* Infectious Period: 3-5 days prior to rash through 4-6 days after onset of rash
* Transmission: Direct contact with droplets and airborne (less frequent)
* Manifestations:
- Prodromal period: 10 days of high fever, 3 C’s = __, __, and __
- __ spots
- Exanthem (rash) - deep red macular rash, blanches with pressure and gradually turns brownish
coryza, cough, conjunctivitis
Koplik
Therapeutic management
* Treating symptoms
* Airborne precautions
* Antipyretics
* Quiet activities and bed rest
* Fluids and humidification
* Antitussives
Prevention ⇒ immunization
> 2 doses of MMR
? (German Measles, 3-day Measles)
Causative agent: RNA virus
Incubation period: 14-21 days
Infectious period: 7 days before onset of symptoms to 14 days after appearance of the rash
Transmission: airborne particles or direct contact with droplets and transplacental transmission (congenital)
Rubella
Manifestations
* Mild disease - rash 14-21 days after exposure
* Young children - asymptomatic until the rash appears
* Older children - profuse nasal drainage, diarrhea, malaise, sore throat, headache, low grade fever, polyarthritis, eye pain, aches, chills, anorexia, and nausea
* Posterior cervical, posterior auricular, and occipital lymphadenopathy
* Pinkish rose maculopapular exanthem - on the face, scalp, and neck - pruritic
* Petechiae (spots) red or purple color or pinpoint on the soft palate - __ __
Forchheimer’s sign
Congenital rubella syndrome (CRS) - after maternal infection
- Intrauterine growth retardation, weight less than 2500 g, failure to thrive in infancy
- Pregnant females should avoid contact
- Presumed contagious until one year or after repeated negative nasopharyngeal and urine cultures
Therapeutic management
- Supportive and symptomatic
- Exclusion from school and should be on droplet precautions for 7 days after onset of rash
- Primary prevention for rubella - MMR vaccine
? (“Fifth Disease” Parvovirus B19)
* Causative agent: parvovirus B19
* Incubation period: 4-17 days up to 28 days
* Infectious period: shedding - 5 and 12 days - from the prodromal period until onset of rash
* Transmission: airborne respiratory droplets, blood, blood products, transplacental transmission
Erythema Infectiosum
Manifestations
* Common in children ages 5-15
* Mild systemic disease
* Prodromal period: headache, runny nose, malaise, and mild fever
* Rash:
> Intense, fiery red edematous rash on face (maculopapular rash) - “slapped cheek” appearance
> 1-4 days after facial rash appears - erythematous, maculopapular rash appears on trunk and extremities - lacy appearance
* Rash can last from 2 to 39 days; can reappear with environmental factors
Therapeutic management
- Symptomatic and supportive
- Antipyretics
- Antihistamines
? (Exanthem Subitum, 3-day fever)
* Causative agent: human herpesvirus 6 (HHV-6)
* Incubation period: 5-15 days
* Infectious period: unknown most likely from febrile stage to onset of rash
* Transmission: contact with secretions such as saliva, CSF
Roseola Infantum
Manifestations
- Prodromal period - sudden high fever 103-106, malaise, irritability, child remains active and alert - fever persists for 3-5 days
- Mild cough, runny nose, abdominal pain, headache, V/D
- After fever subsides within several hours to 2 days - rash appears
- Rose-pink maculopapules or macules, blanche with pressure, whitish ring
Therapeutic management
- Symptomatic
- Antipyretics
- Lightweight clothing
- Cooler environmental temperatures
- Increase fluid intake
Enteroviruses - ___ (hand, foot and mouth)
Causative agents: RNA viruses
Incubation period: 3-6 days
Infectious period: unknown
Transmission: fecal-oral and oral-oral: contact precautions
Manifestations
- Prodromal period: fever
- Vesicles in mouth, on palms of hands, soles of feet, and sometimes on buttocks
Coxsackievirus A
Therapeutic management
- Symptomatic
- Special attention to dehydration
- Hand hygiene/personal hygiene/diaper changes/bathroom use
- Analgesics (acetaminophen)
- Soft or cool liquid diet - milk-based ice cream
- For oropharyngeal lesions
> Rinse mouth with salt and water or
> “Magic mouthwash”
* Equal parts of lidocaine gel, diphenhydramine liquid, and liquid antacid
Varicella zoster infections (chicken pox and shingles)
* Causative agent: varicella zoster virus
* Incubation period: 10-21 days
* Infectious period: 1-2 days before onset of rash and until all lesions are dried and crusted over
* Transmission: direct contact (open vesicles), droplet, airborne particles
* Immunity: either by natural disease of varicella or varicella vaccine
Manifestations: Varicella
* Prodromal period: 24-48 hours before onset of lesions
> Low-grade fever, malaise, headache, and anorexia
* On trunk and scalp
> teardrop vesicles with an edematous base > pustular vesicles > crust
Herpes zoster (shingles)
* Primary infection with varicella - lays dormant
* Activation causes herpes zoster - shingles
> Must have had chickenpox previously to get herpes zoster
* Tenderness along the involved nerve and surrounding skin for approximately 2 weeks before lesions
* Rash is unilateral - along a single dermatome of one or more sensory nerves
Therapeutic management (chickenpox and shingles)
* Symptomatic and supportive
* Oatmeal baths
* Antipyretics (acetaminophen and NEVER ASA)
* Antihistamines
* Avoid scratching the lesions to prevent scars and infection
* Airborne and contact precautions until lesions scabbed
* Prevention through vaccination (1st dose on or before 1st birthday and booster between ages 4-6)
* For herpes zoster
> analgesics; acyclovir; airborne and contact precautions (strict isolation)
?
* Causative agent: paramyxovirus
* Incubation period: 16-18 days can go up to 25 days
* Infectious: 7 days prior to swelling (parotitis) and up to 9 days after onset
* Transmission: airborne droplets, salivary secretions, and possibly urine
Manifestations
- Prodromal: fever, myalgias, headaches, and malaise
- Pain with chewing, earache, pain in the jaw line in front of the ear
- Male complication - inflammation of the testes (___ ?)
Mumps
orchitis
Therapeutic management
* Symptomatic care and adequate hydration
* Soft or liquid diet
* Avoid acidic foods such as orange juice
* Droplet precautions until 5 days after onset
* Antipyretic
* For orchitis - bedrest, intermittent application of ice packs, pain management, emotional support and diversional activities
* Prevention - vaccination with the MMR vaccine
?
* Causative agent: human cytomegalovirus
* Incubation period: unknown
* Transmission: saliva, urine, blood, semen, cervical secretions, breast milk, organ transplants
* Leading cause of hearing loss and intellectual disability in infants in the US
Therapeutic management
> Early detection of disabilities
> Hearing aids, cochlear implants, speech therapy
> Detect learning disabilities and early interventions with physical speech and cognitive therapy
Cytomegalovirus (CMV)
? (Epstein-Barr Virus [EBV])
* Incubation period: 4-7 weeks
* Infectious period: unknown
* Transmission: direct contact through saliva, intimate contact or blood
Infectious Mononucleosis
Manifestations
* Prodromal period: fever, exudative pharyngitis, lymphadenopathy (cervical, axillary, and inguinal)
* Enlarged lymph nodes, sore throat, high fever, pain with swallowing, petechiae on palate, enlarged tonsils with white exudate, and firm, tender, cervical lymph nodes
* May develop to abdominal pain with liver and spleen enlargement - hepatosplenomegaly
Therapeutic management
* Supportive
* Steroids PRN for acute tonsillar swelling
* Rest; avoid physical activity and contact sports to minimize the risk of rupturing the spleen
* Antipyretics
* Hydration
* Soft or liquid diet and foods; milkshakes
?
* Causative agent: rhabdovirus
* Incubation period: 5 days to more than 1 year
* Infectious period: 10 days
* Transmission: bites with contaminated saliva, scratches from claws of infected animals, airborne from bat infested caves
Manifestations
> Slowly developing infection
> Prodromal period: sore throat, headache, fever, anxiety
> Discomfort at the site of the bite, hyperactivity, muscle spasms (involuntary twitching) or convulsions
> Decreased ability to swallow (contractions of the mouth) resulting in drooling or aspiration
> Coma, death
Rabies
Therapeutic management
- Prevention is important
- Cleanse bite wound with large amounts of soap and water
- Administer human rabies immune globulin (HRIG)
- Rabies vaccination
Bacterial Infections
* Organisms that contain both DNA and RNA
* Complex cell wall
* Classified as gram-positive or gram-negative bacteria
* Bacteria secrete toxins (exotoxins, endotoxins)
* Whooping cough
* Scarlet fever
* Cellulitis
* Methicillin Resistant Staphylococcus Aureus (MRSA)
* Clostridium difficile (C. diff)
* Impetigo
Rare Viral & Bacterial Infections
* Poliomyelitis infantile paralysis
* Diphtheria