The Cell Surface Flashcards
what is the structure of the cell membrane?
- Composed of lipids ( mainly phospholipids) and proteins
- There are two opposing sheets of lipids into which proteins are inserted (called a bilayer)
- Hydrophobic tails face out towards fluids
- Fatty acid chains determine fluidity of membrane
what is the structure of a phospholipid?
has a hydrophobic tail and a hydrophilic head
what does amphipathic mean?
they have a polar and a hydrophobic part
what is the function of a cell membrane?
barrier- between the cells/cell organelles and their environment, controlling which substances enter and leave.
compartmentalisation – maintain different internal environments
Site of chemical reactions – inner membrane of mitochondria (cristae) contains enzymes needed for cellular respiration.
Membranes also protect vital cell components e.g. DNA.
cell recognition- e.g. cells of the immune system. (Glycolipids)
cell communication - (cell signalling (Glycoproteins)
what are the 4 major phospholipids in the mammalian PM?
- phosphatidylcholine
- phosphatidylserine
- phosphatidylethanolamine
- sphingomyelin
how are all the phospholipids able to link together?
They all have similar structure so are able to link together
Only head group is different (EXCEPT
Sphingomyelin)
what are intracellular signal transduction lipids?
They are a minor proportion of the phospholipid content of intracellular membranes.
Derived from lipids residing in the PM
Bind specifically to conserved regions found within many different proteins and once bound, induce conformational and/ or localisation and activity changes within these proteins
what are the features of intracellular signal transduction lipids?
Rapidly generated/ destroyed by enzymes in response to a specific signal (to prevent continuous signals)
They are spatially and temporally (at a specific space at a specific time) generated giving a highly specific signal.
what are 4 examples of intracellular signal transduction lipids?
▪ Phosphatidylinositol
▪ Diacylglycerol
▪ Ceramide
▪ Sphingosine-1-phosphate
what are glycolipids?
located on non-cytosolic half of membrane
glycosylated in Golgi apparatus
Important for recognition and cell attachment
what is the structure of cholesterol?
- 4-ringed ridged planar structure
- Polar head group interacts with the hydrophilic head
- hydrophobic hydrocarbon tail
what is the role of cholesterol in the PM?
Inserts between membrane phospholipids
This tightens packing in the bilayer/ membrane rigidity and decreases membrane permeability to small molecules
Regulates cell membrane fluidity
At 37C cholesterol makes the membrane less fluid – stabilises interactions between neighbouring phospholipids
what does cholesterol do to proteins?
Cholesterol also stabilises protein groups which makes communication easier
what does the fluidity of the PM allow it to do?
Allow signalling lipids and membrane proteins to rapidly diffuse in the lateral plane and interact with one another
Fluidity is important in cell division- ensures membranes are equally shared between daughter cells following cell division
Allows membranes to fuse with other membranes e.g. in exo/endocytosis
what are transmembrane proteins and why are they integral?
proteins that span the entire lipid bilayer
integral bc they go through both layers