The Biological Approach Flashcards
Research support for neurotransmitters and behaviour
Rogers and Kesner 2003
Antonova 2011
Neurotransmitters and Behaviour
Describe the structure of the nervous system (2)
•Is a system of neurons
•Neurons consist of body, dendrites and axon
Neurotransmitters and Behaviour
Describe neurotransmitters (3)
•Chemical messengers
•Can be excitatory (increase likelihood of neural firing) or inhibitory (decrease)
•Their action can be affected by agonists or antagonist (either enhance or counteract action of neurotransmitters)
Neurotransmitters and Behaviour
Explain the role of neurotransmitters in neural firing (5)
•Transmission is partly electrical, partly chemical
•Synapse=junction between 2 neurons
•Electrical impulse builds up at synapse and travels across axon
•At end of axon, neurotransmitter released into synaptic gap
•When neurotransmitter binds to post-synaptic neuron’s receptors, it changes it’s electric potential helping to build next impulse.
Rogers and Kesner 2003
What is the role of acetylcholine?
Consolidation of memory in the hippocampus
Rogers and Kesner 2003
Aim
Determine the role of acetylcholine in the formation of spatial memory
Rogers and Kesner 2003
Sample
30 rats
Rogers and Kesner 2003
Method
Lab Experiment, Independent Measures Design
Rogers and Kesner 2003
Procedure (7)
•Rats acclimated to Hebb Williams Maze by placing food in one corner
•When all rats acclimated, experiment began
•Half of sample injected directly into hippocampus with scopolamine (acetylcholine antagonist)
•Other half injected w placebo because injections cause secretion of adrenaline which could become confounding variable
•Rats placed in maze and amount of mistakes made when navigating maze were counted
•Encoding of spatial memory measured by comparing no. of mistakes made in first 5 and last 5 trials of day 1
•Retrieval measured by comparing no of mistakes made in last 5 trials of day 1 and first 5 of day 2
Rogers and Kesner 2003
Results (1)
*Rats injected w/ scopolamine made more mistakes than those injected w placebo and took longer to navigate maze
Rogers and Kesner 2003
Conclusion (1)
Acetylcholine plays significant role in formation of spatial memory
Rogers and Kesner 2003
Strengths (3)
High Control of Variables, i.e use of placebo to prevent confounding variables = high internal validity therefore, strong cause and effect relationship
Reliable as study has been applied to humans and same results achieved
Research is useful as it could one day be used to develop treatments for alzheimers or dementia
Rogers and Kesner 2003
Weaknesses (3)
*Reductionist approach to understanding memory; there are so many different types of memory and memory consolidation is very complex
*No significant results for retrieval of memory
*Ethical concerns for use of animals, (could have used a smaller sample, could have administered acetylcholine through foods w choline instead of injecting)
Antonova et al 2011
What experiment did they replicate on humans?
Rogers and Kesners investigation into the role of acetylcholine on formation aof spatial memory
Antonova et al 2011
Aim
Determine if scopolamine affects hippocampal activity in creation of spatial memory
Antonova et al 2011
Sample
20 healthy males; mean age 28