The basics Flashcards
Environmental toxin
chemical substance
that is in the environment & harmful to
living organisms
sources where environmental toxins are found:
Industrial (i.e., factories),
Agricultural (i.e., pesticides), Urban (i.e.,
vehicle emissions, construction materials),
Household products (i.e., cleaning,
personal care) Natural (mold, fungi,
plants), Electronic waste, etc
environmental toxins
can be classified into two general categories:
chemical and biological
Chemical Toxins:
These include synthetic
chemicals (e.g., pesticides, industrial pollutants,
& other man-made substances) or naturally
occurring (e.g., heavy metals)
Biological Toxins:
Naturally occurring
substances produced by living organisms, like
bacteria (e.g. botulinum), fungi (e.g., ,mycotoxins),
animals (e.g., snake venom) & plants (e.g.,
cyanide)
Exposure to mercury has been
shown to impair:
neurogenesis
neurogenesis
the growth and development of nervous tissue.
toxicology
the scientific
study of the effects of chemicals on
living organisms
Focuses on the harmful/adverse effects
chemicals may have
There are different ‘specialized’
areas of toxicology:
These include: (i) descriptive
toxicology, (ii) mechanistic
toxicology, (iii) regulatory
toxicology, (iv) forensic toxicology,
(v) clinical toxicology, (vi)
environmental toxicology, (vii)
ecotoxicology
Toxicological endpoint =
a specific biological
effect observed in a living organism following
exposure to a toxic substance
Used to assess the substance’s potential harm
Dioxins =
group of chemically-related
compounds
Neurotoxicity -
Adverse effects of
substances on the nervous system, leading
to damage or impairment of neurons, glial
cells, or neural networks
DNT -
Neurotoxic effects during prenatal
development or early childhood,
potentially causing lasting changes in brain
structure & function
Mechanistic toxicology -
focuses on the
specific biological mechanisms of chemicals’
toxic effects
Regulatory toxicology-
Assessing whether a drug or chemical poses a
risk to human health
Uses information gathered from toxicity testing
(e.g., mechanistic & descriptive studies)
Establishes standards &/or guidelines for safe
exposure