The Autonomic Nervous System Flashcards

1
Q

Peripheral nervous system (PNS)

A

Somatic nervous system

Motor and sensory pathways regulating voluntary motor control of skeletal muscle

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2
Q

Autonomic nervous system

A

Motor & sensory pathways regulating the body’s internal environment through involuntary control of organ systems (smooth muscle, cardiac muscle, and glands)

  • Sympathetic– FFF
  • Parasympathetic– Rest and digest
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3
Q

Describe the Neurons of the ANS

A

Preganglionic:
cell body in CNS (myelinated B fibers)
Postganglionic:
cell body in autonomic ganglia (unmyelinated C fibers)

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4
Q

Two divisions classified anatomically

(often but NOT ALWAYS physiologic antagonists)

A

Sympathetic
Parasympathetic
+/- Enteric

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5
Q

Activation of the ANS via autonomic centers in:

A
Hypothalamus (influenced by connections to limbic system)
Brain stem 
--Medulla- Vasomotor vasodilation 
--Pons- micturition 
Spinal Cord

Controls Visceral Functions

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6
Q

ANS partial Control

A
Partial control
Systemic blood pressure
GI motility and secretion
Urinary bladder emptying
Sweating and body temperature
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7
Q

Sympathetic innervation
Thoracolumbar:
-Preganglionic
-Post ganglionic

A

Preganglionic neurons cell bodies located in (T1-L2/3) of spinal cord
Intermediolateral horn of grey matter
Post ganglionic neuron cell bodies are located in ganglia
Paravertebral chains (either side spinal column)
Prevertebral ganglia (i.e. celiac, superior, inferior mesenteric ganglia in abdomen)
Short preganglionic neurons, long post ganglionic

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8
Q

The Sympathetic Nervous System (Thoracolumbar division)

How do nerve fibers leave the spinal cord?

A

Nerve fibers leave the spinal cord ventrally via white rami and travel to 22 paravertebral ganglia (the sympathetic chain ganglia)

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9
Q

From the 22 paravertebral ganglia (the sympathetic chain ganglia) nerve fibers synapse with?

A

Synapse with post-ganglionic neuron at same level OR
Move caudad or cephalad to synapse at another level
Pass ganglia without synapsing to collateral ganglia surrounding the abdominal aorta (celiac, superior mesenteric, inferior mesenteric)
Some ganglia have inhibitory interneurons as well

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10
Q

From the 22 paravertebral ganglia (the sympathetic chain ganglia) nerve fibers synapse with?

A

Synapse with post-ganglionic neuron at same level OR
Move caudad or cephalad to synapse at another level
Pass ganglia without synapsing to collateral ganglia surrounding the abdominal aorta (celiac, superior mesenteric, inferior mesenteric)
Some ganglia have inhibitory interneurons as well

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11
Q

Post-ganglionic nerve cell bodies found in ganglia of paravertebral chain exit to travel to various peripheral organs. How do they return to spinal nerves via

A

via gray rami travel with these nerves to blood vessels, piloerector muscles and sweat glands

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12
Q
Note: Distribution of SNS fibers is based on embryonic development and NOT spinal segments
T1 
T2 
T3-6 
T7-11
T12-L2
A
Distribution 
T1 SNS fibers usually ascend into the paravertebral sympathetic chain to head
T2 neck
T3-6 chest
T7-11 abdomen
T12-L2 legs
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13
Q

Parasympathetic innervation

Pre-ganglionic neurons

A

arise in
“Cranial” (medullary CN 3,7, 9, 10)
“Sacral” (spinal cord S2-4) regions

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14
Q

Post-ganglionic neurons cell bodies located in:

A

Target organs
Discrete ganglia in the head and neck (i.e. ciliary ganglia)
Long preganglionic neurons, short post

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15
Q

Parasympathetic Nervous System “Craniosacral division”

A

Functions to conserve and restore energy

“Rest or repose response”

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16
Q

Parasympathetic Nervous System “Craniosacral division”

A

Receives innervation from cell bodies located in:
cranial nerve nuclei (travel via III, V, VII, IX, X)
75% of PSNS fibers are in vagus (X) passing to abdominal and thoracic areas

17
Q

a1 Receptors

Gq protein

A
NE/ EPI
produce excitation (e.g., contraction or constriction).
PLC activated
IP3 & DAG
PKC and↑ Ca2+
18
Q

M1

Gq protein

A
ACh and muscarine
excitatory in smooth muscle and glands  
PLC activated
IP3 & DAG
PKC and↑ Ca2+
Gq protein, stimulation of phospholipase C, and increase
in IP3 and intracellular [Ca2+].
19
Q

M2

Gi protein

A
ACh
Gi protein,
Inhibit adenylate cyclase
↓ cAMP
↑ K+ channels, slowing of the rate of spontaneous Phase 4 depolarization, and
decreased heart rate.
20
Q

M3

Gq protein

A
ACh and muscarine
excitatory in smooth muscle and glands  
PLC activated
IP3 & DAG
PKC and↑ Ca2+
21
Q

Nm

Ligand gated Ion Channel

A

NM (N1) Skeletal muscle — Opening Na+/K+ channels

22
Q

Nn

Ligand gated Ion Channel

A

NN (N2) Autonomic ganglia — Opening Na+/K+ channels

23
Q

B1 B2

Gs protein

A

b1 Receptors- heart => excitation
b2 relaxation (e.g., dilation of vascular smooth muscle, dilation of bronchioles,
relaxation of the bladder wall).