The Adrenals and their Hormones

Question 1

What are the parts of the adrenal gland from the outside to the inside?

Answer 1

Zona Glomerulosa (aldosterone production)
Zona Fasciculata (cortisol and sex steroids)
Zona Reticularis (cortisol sex steroids)
Adrenal Medulla

Question 2

What is the direction of blood flow in the adrenals?

Answer 2

From the cortex towards the medulla

Question 3

What is produced by the adrenal medulla? What are the cells involved called?

Answer 3

Catecholamines by the Chromaffin cells

Question 4

What is produced in the adrenal cortex? State the four hormones produced.

Answer 4

Corticosteroids:
Mineralocorticoids - aldosterone
Glucocorticoids - cortisol
Sex Steroids - androgens and oestrogens

Question 5

What is androstenedione?

Answer 5

It is a weak androgen that can be converted to testosterone and dihydrotestosterone

Question 6

How are corticosteroids transported in the blood?

Answer 6

They bind to plasma proteins.
There is so much albumin that some corticosteroids will non-specifically bind to albumin.
There are more specific plasma proteins - corticosteroid binding globulin

Question 7

Describe the difference in the blood concentrations of cortisol and aldosterone.

Answer 7

The concentration of cortisol is 1000 times greater than the concentration of aldosterone.

Question 8

How does cortisol concentration vary?

Answer 8

Cortisol concentration changes with the circadian rhythm. It is a stress hormone so is released more at times of stress.

Question 9

What are the effects of aldosterone?

Answer 9

Increased potassium and H+ secretion

Increase sodium reabsorption

Question 10

Describe the mechanism of action of aldosterone.

Answer 10

Aldosterone binds to intracellular receptors and translocates to the nucleus and causes changes in transcription leading to the synthesis of ion channels and pumps.

Question 11

Describe the arrangement of the juxta-glomerular apparatus in the kidneys.

Answer 11

The juxta-glomerular cells are in contact with the afferent arteriole.
The macula densa cells are next to the juxta-glomerular cells

Question 12

What hormone is stimulated by an increase in plasma osmolality?

Answer 12

Vasopressin

Question 13

What is a consequence of increase extracellular fluid volume?

Answer 13

Hypertension

Question 14

Describe how the juxtaglomerular apparatus can lead to production of aldosterone.

Answer 14

Macula densa detects a decrease in tubular sodium concentration and stimulates the release of renin from the juxta-glomerular cells. Renin stimulates the production of angiotensin II, which upregulates aldosterone release.

Question 15

State three causes of renin release.

Answer 15

Decreased renal perfusion pressure
Increased renal sympathetic activity
Decreased sodium concentration at the top of the loop of Henle

Question 16

Describe the steps in the production of angiotensin II from the angiotensinogen.

Answer 16

Renin converts angiotensinogen (produced by the liver) to angiotensin I
Angiotensin I is converted by ACE (which is found in high concentration in the lung endothelium) to Angiotensin II

Question 17

What are the effects of cortisol?

Answer 17

Increases blood glucose availability for tissues to be used in growth.
Liver- promotes glycolysis and gluconeogenesis and indirect role in promoting glycogenolysis
Skeletal muscle and fat: -
1) decreases blood flow to these tissues,
2) decreased fatty acid and glucose transporter at these tissues so that FA and glucose can’t enter skeletal muscle or fat

Question 18

What are the three effects of large amounts of cortisol?

Answer 18

Anti-inflammatory
Immunosuppressive
Anti-allergic
Negative effects on memory

Question 19

Which receptors do a) aldosterone and b) cortisol bind to?

Answer 19

Aldosterone - mineralocorticoid receptors

Cortisol - glucocorticoid receptors AND mineralocorticoid receptors

Question 20

Describe the mechanism of action of cortisol.

Answer 20

Cortisol binds to intracellular receptors, moves to the nucleus and causes a GENOMIC change.

Question 21

Describe the control of cortisol.

Answer 21

There is direct negative feedback by ACTH on the hypothalamus
Cortisol also have negative feedback effects on the hypothalamus and on the adenohypophysis

Question 22

What is dehydroepiandrosterone (DHEA)?

Answer 22

This is a very weak androgen that peaks around 20-30 years. It is particularly important in post-menopausal women as a precursor for oestrogen.

Question 23

As cortisol has a much higher blood concentration than aldosterone, why doesn’t cortisol constantly bind to mineralocorticoid receptors?

Answer 23

The kidneys have an enzyme called 11 beta-hydroxysteroid dehydrogenase 2 that converts cortisol into the inactive CORTISONE.