Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hemorhagic viruses > The 4 major hemorhagic viruses > Flashcards

The 4 major hemorhagic viruses Flashcards

1
Q

All VHF viruses are what kind of viruses?

A

RNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Name the 4 VHF viruses

A

Arenaviridae, bunyaviridae, Floriviridae, flavivirida

Arena, bunya, flora, flavi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Two flaviviruses

A

Dengue fever and yellow fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the structure of flavi?

A

enveloped +RNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe the flavivirus replication process

A
  • Enters via pH dependent receptor mediated endocytosis
  • +RNA genome is translated into one polyprotein which is cleaved to give viral polymerase and structural proteins
  • Virions bud into intracellular organelles and are transported to surfact via exocytic pathway
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What happens in a flavivirus infection?

A

Mosquito bites, virus initially replicates at the site.
Virus seeds itself in secondary target tissue, Macrophage, spleen, lymph….This is when you get flu-like symptoms
Secondary viremia starts, if no immune response you get yellow fever hepatitis….Dengue virus infects endothelial cells and leads to hemorrhagic feartures.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dengue Fever

A

Mostly aquired abroad…four serotypes (1,2,3,4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Infection with one serotype does not provide protection to the others.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

If you have been infected with dengue once, it is more serious the second time.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dengue symptoms

A

Flu like, rash, treatement with fluids and tylenol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the more severe form of Dengue fever

A

Dengue hemorhagic fever…characterized by severe thrombocytopenia, leads to intense capillary leakage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Is it important to get a lab confirmation for Dengue fever?

A

Yes…it can appear very similar to other illnesses like malaria.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How do you test for Dengue

A

Look for 4 fold raise in antibody titer in IgG or IgM.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How do you treat Dengue hemorrhagic fever

A

Platelett transfusion and fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does yellow fever presesnt as?

A

flu-like, progresses to hemorhagic fever, jaundive (hence the yellow), black vomit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Is there a vaccine for yelow fever

A

Yeah, live attenuated

17
Q

Hos is yellow fever spread?

A

Usually in the jungle through mosquitoes and primates. Humans become infected and take it back to urban environments where it is then spread through mosquitos.

18
Q

How does YF progress

A

Most cases are asymptomatic. For those that cause sickness, the initial infectionis flu like. Then comes a brief remission. Then comes the pain….fever, jaundice, bleeding, shock

19
Q

Treatment is YF

A

Supportive, fluids, vasoactive meds, etc…

20
Q

Bunyavirus structure

A

Enveloped, segmented, single strand, -RNA

21
Q

Three kinds of bunya

A

Rift valley fever, crimean congo,Hanta

22
Q

How is rift valley fever transmitted

A

Mosquitoes

23
Q

Crimean congo

A

ticks

24
Q

Hanta

A

rodents

25
Q

Buntavirus replication cycle

A

Endocytosed, viral polymerase carried within virion transcribes +RNA (this must be first!
This RNA is translated by host proteins

26
Q

Rift valley fever hihglights

A

causes abortion in livestock
potential bioterrorism agent
majorioty of human infection from blood or organs of dead animals

27
Q

RVFV in humans

A

Flu like at first, only progresses in 2% of pts,

28
Q

WHat organ is most affected by RVFV

A

Liver…also a nerological component like meningitis, fever, encephalitis, possible blindness

29
Q

Crimean congo highlights

A

headache, limb pain, bleeding from orifices

30
Q

Hantavirus highlights

A

Spread through rodents excretion, 1-2 weeks after exposure, fever, hemorhage, renal failure, 15% mortality rate

31
Q

Arenavirus

A

enveloped, segmented ambiscence, aerosol spread, bioterrorism

32
Q

arenavirus vaccine

A

No

33
Q

Filovirus structure

A

envelope, non seg, -RNA

34
Q

Two filoviruses?

A

Marburg and EBOLA

35
Q

Filoviruses highlights

A

Very high fatality, spread through direct contact with blood and body fluid

36
Q

Filo replication

A

binds a protein, Membrane fusion initiated by Cathepsin and low pH, brings in a viral RNA polymerase to make +RNA,

37
Q

Ebola is macrophage and monocyte trophic

A

True

38
Q

Ebola presentation

A

Bleeding from skin and orrifices, huge spleen, lesions on liver

39
Q

Treatment of Ebola

A

You’re fucked…take fluids and pray

Hemorhagic viruses (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions