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Respiratory > Tetracyclines > Flashcards

Tetracyclines Flashcards

1
Q

Pharmacokinetics of tetracycline

A

Oral
Impaired by food and cations

ENTEROhepatic recycling

Doxycycline is not hepatically metabolised excreted in feces so it and tigecycline can be given in renal patients.

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2
Q

MOA

A

Bind 30s ribosomes
Prevents binding of aminoacids tRNA to ribosome and mrna complex

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3
Q

Primary use

A

Mycoplasma pneumonia in adults
Chlamydia, rickettsiae, vibrios
CAP

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4
Q

Secondary use

A

Syphilis
Prophylaxis against chronic bronchitis
Resp infection

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5
Q

Uses

A

H pylori
Lyme disease =doxycycline
Meningo coccal carrier= minocycline
Prevents malaria
Amebiasis

Demecocycline inhibits ADH
TIGECYCLINE = oral, IV

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6
Q

Toxicity

A

Nausea, diarhea,
Enterocolitis
Candidiasis
Enamel dysplasia
Hepatotoxic
Renal toxic
Photosensitive
Vestibular toxicity

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Respiratory (3 decks)

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