Testicular Tumors

Question 1

Aside from PLAP and OCT 3/4, what two other IHCs will be positive for Embyonal Carcinoma of the testis?

Answer 1

CK and CD30

Question 2

What are the two testicular tumors that usually present with hemorrhage and necrosis grossly?

Answer 2

Embryonal and Choriocarcinoma

Question 3

Give two IHCs for yolk sac tumor.

Answer 3

Alpha-fetoprotein and alpha 1 anti-trypsin

Question 4

What are the three IHCs for Seminoma?

Answer 4

PLAP, OCT4 and KIT

Question 5

Genetic alteration in Seminoma?

Answer 5

Isochromosome 12p reduplication and KIT amplification in 25%

Question 6

In postpubertal males, all teratomas are regarded as malignant, True or False?

Answer 6

True. They are capable of metastasis whether elements are mature or immature.

Question 7

What testicular tumor is this?
Most are benign or malignant?
Presents with gynecomastia as first symptom.
Golden brown homogenous cut surface.
Microsections disclose large round or polygonal cell outlines, abundant granular eosinophilic cytoplasm with rod shaped crystalloids.

Answer 7

Leydig Cell Tumors
Most are benign,
10% malignant

Question 8

What testicular tumor is being described?
Hormonally silent.
Cut section shows a gray-white to yellow homogenous surface.
Tumor cells in trabeculae or cordlike.
Is this tumor usually benign or malignant?

Answer 8

Sertoli Cell Tumor.

Mostly benign, 10% are malignant.