Test Review

Question 1

Major cell type composing of breast ducts is?

Answer 1

Epithelial

Question 2

Technique used to detect specific DNA sequences in a sample (SRC IN human tissue)

Answer 2

Southern blot

Question 3

Which enzyme cleaves proteins?

Answer 3

Trypsin

Question 4

Cancer cells spreading beyond the primary organ is called?

Answer 4

Metastasis

Question 5

Situation where cells abnormally appear in the gland but haven’t progressed past the basement membrane:

Answer 5

Ductal carcinoma

Question 6

Process by which normal cells are transformed into cancer cells is knows as

Answer 6

Carcinogenesis

Question 7

Mustard gas is an

Answer 7

Alkylating agent

Question 8

Oxidation produces:

Answer 8

hematoxylin

Question 9

What is ALL?

Answer 9

Acute lymphoblastic leukemia

Question 10

What percentage of experimental cancer drugs fail?

Answer 10

90%

Question 11

What type of enzyme adds OH groups to PAHDs to make them more soluble?

Answer 11

cytochrome p450s

Question 12

Due to the rise of blank this is the number one cancer killer.

Answer 12

Cigarettes, lung cancer

Question 13

What structure does vincristine interact with?

Answer 13

Microtubules

Question 14

Are viruses alive?

Answer 14

No or Yes

Question 15

Which viruses are known to cause cancer?

Answer 15

All of the above (barr, hep C)

Question 16

Herceptin is successful in treating.

Answer 16

ERbb2+ breast cancer

Question 17

Which of the following is true about protooncogene?

Answer 17

It is present in each cell.

Question 18

1986 workshop that led to human genome project was started in.

Answer 18

Santa fe

Question 19

CAMP combination chemotherapy works by

Answer 19

All of the above

Question 20

Which viruses cause cancer?

Answer 20

All of the above (HIV, HPV)

Question 21

Anatomist who created a detailed map of the human body de human corporis fabrica

Answer 21

Andreas Vesalius

Question 22

What type of radiation does galactography employ?

Answer 22

x-rays

Question 23

Intercirculating agent commonly used to stain DNA gels under UV light.

Answer 23

Ethidium bromide

Question 24

Acute lymphoblastic leukemia is the cancer of the

Answer 24

Bone marrow

Question 25

Apoptosis is mediated by.

Answer 25

Protease crusade

Question 26

What medical procedure did William Hallsted conduct in pathology labs is

Answer 26

Radical mastectomy

Question 27

Carcinomas are tumors of what tissue type.

Answer 27

Epithelial

Question 28

What is the origin of HER 2 positivity in some breast cancer?

Answer 28

Gene amplification

Question 29

Sarcomas are cancer of what type of tissue.

Answer 29

Connective

Question 30

Gold standard to detect hwr2 gene amplification?

Answer 30

Fluorescent in situ hybridization

Question 31

What chemical structure is found in carcinomas?

Answer 31

Polyaromatic hydrocarbon rings

Question 32

What cancer is fatal among children?

Answer 32

Leukemia

Question 33

What is the main macromolecule that is damaged by cigarettes.

Answer 33

DNA

Question 34

Which was the most common microcellular subtype of Breast cancer?

Answer 34

Luminal

Question 35

Hematoxylin stains the blank cellular component.

Answer 35

Nuclear

Question 36

What do reverse transcriptase’s do?

Answer 36

Generate DNA from RNA template.

Question 37

What finding led to the idea that cancer cells may be targeted by chemicals

Answer 37

Cells had affinity to certain dyes.

Question 38

Requirement for post-op stage rating 2 is.

Answer 38

<2cm and spread to only local lymph nodes.

Question 39

Aminopterin decreases the availability of blank in cancer cells disrupting proliferation.

Answer 39

Nucleotide precursors

Question 40

Administration of aminopterin to Robert led to

Answer 40

Reduction in blast cells

Question 41

What does DAPI bind to

Answer 41

AT regions in DNA

Question 42

Solid tumor STAMP was a way to

Answer 42

Give patients high does chemo without damaging bone marrow.

Question 43

Which mechanism describes retro viruses introduce genome to a host?

Answer 43

Revers transcription

Question 44

Which drug had 100% response rate?

Answer 44

Gleevec

Question 45

What was alias name of Boston boy to increase cancer awareness?

Answer 45

Jimmy

Question 46

What international effort analyzed samples of cancer?

Answer 46

Cancer genome project

Question 47

Seed and soil hypothesis helped to form understanding of blank contributes to tumor progression.

Answer 47

Microenvironment

Question 48

Which of these tactics determined course of treatment?

Answer 48

MammoPrint

Question 49

Sidney Farber achieved clinical remission of Leukemia in children.

Answer 49

True

Question 50

Behavior of cancer clusters had ben paralleled to

Answer 50

Infectious disease

Question 51

Outcomes of rubein and tuemins RSV check fibroblast inaction

Answer 51

Chicken cells survived, transformed.

Question 52

Multistage carcinogenesis recognizes link between

Answer 52

Age

Question 53

Hyperplastic atypia in breast tissue is always a sign of malignancy.

Answer 53

False

Question 54

What is mechanism of action of Gleevec?

Answer 54

Competitive inhibitor

Question 55

What nonchemical reaction is occurring in hematoxylin to hematein?

Answer 55

Oxidation

Question 56

CAR T therapy is used to treat.

Answer 56

Blood cancer

Question 57

Which cell is the most in circulating white blood cells?

Answer 57

Neutrophiles

Question 58

Which of the following is a typical application of RBNA sequencing?

Answer 58

Quantifying gene expression levels

Question 59

Why was Gleevec so successful?

Answer 59

Philadelphia mutation occurs in CML.

Question 60

Tamoxifen targeted and treats.

Answer 60

Estrogen, breast cancer

Question 61

Gleevec is a tyrosinase kinase inhibitor.

Answer 61

True

Question 62

How many ERbB are there?

Answer 62

4