Test Prep Flashcards
Breast Cancer- Annual Incidence and Hereditary % to % Familial %
255,000 and 12-14% Fam 15-40%
Breast Cancer- % risk with BRCA mutation, % risk of second breast cancer, and general population risk of 1st and 2nd?
up to 87%, 64%, GP 1st 14.8 2nd 11%
Ovarian Cancer- Annual incidence and Hereditary % Familial %
22,000 and 24% Familial 4-11%
Ovarian- % risk with BRCA mutation and % risk with Lynch mutation. General Population % risk
up to 63%, up to 12%, and >1%
Uterine/Endometrial - Annual incidence and hereditary % Familial %
61,000 and 9% Familial 4%
Uterine/Endometrial - % Risk with Lynch Mutation and General Population risk?
71% and 1.5%
Colorectal Cancer- annual incidence and hereditary %
135,000 and 10%
Colorectal - % risk with Lynch Mutation, General Population % risk, and Second cancer overall and Familial %
82% (myRisk 99% with FAP), GP 3.4%, and 38% Familial 4-20%
HBOC- Population risk for breast cancer % to % or 1/8 regardless of family history.
12 to 14%
Breast cancer - median age?
55-65
HBOC- % chance of ovarian cancer with BRCA 1/2 and % risk of Breast Cancer with BRCA 1/2 mutation?
63% and 87%
BSO can reduce ovarian cancer by what %? And Breast %
96% and 68%
Colon/ Lynch Syndrome - Median age? Annual incidences?
General Population late 60s to late 70s. 135,000 per year
Screen using colonoscopy- what are they looking for?
polyps
If you have a lynch mutation, polyps can become cancerous in how many years?
1-3 years
Polyps usually take how many years to become cancerous in general population?
5-10 years
Individuals with Lynch syndrome have a % chance of developing colorectal cancer? Individual with Lynch syndrome have a % chance of developing stomach cancer?
82% and 13%
Individuals with Lynch syndrome have a % risk of developing ovarian cancer?
12%
Individuals with Lynch syndrome have a % risk of developing endometrial. Patient may present with abnormal bleeding.
71%
Cancer Risk- Hereditary - what is the cause?
genetic
Cancer Risk- Familial- what is the cause
combination of genetic and environmental
Cancer Risk - General Population- what is the cause?
Environmental
What is a germline mutation?
A mutation from the egg or sperm that is found in all cells of your body (myRisk testing) these are inherited.
What is a somatic mutation?
mutation that first occurred in a particular cell (tumors) These are genetic changes that are acquired (environmental like UV or Chemical exposure) and are not inherited. They are not found in all cells of the body.
Name the 8 cancers on myRisk - COME-PPBG
Colorectal, Ovarian, Melanoma, Endometrial, Pancreatic, Prostate, Breast, and Gastric
Red Flags- MYR- what is this?
Multiple- combo of cancers in a patient or on the same side of the family. Young- Age <50 in patient or family members. Rare- Rare cancer at any age (ovarian)
What 2 Federal Legislation protect patients?
GINA- prohibits employers and health insurers from discrimination against those with genetic conditions. HIPAA- Protects patient health information.
How should providers handle VUS results?
As though they are negative, and base medical management on the patients personal and family history.
Patient Case- Patient with BRCA 1 mutation in family and the patient test is negative. What is she considered?
A True negative and is at general population risk.
Patient Case- We test a patient and she comes back positive for BRCA 1/2. What age should MRI with contrast begin? What is her % change of developing breast cancer?
25 and up to 87%