Test One Flashcards
What are the functions of blood
Transport, Protection, Regulation
Define volume of blood
Varies with body size, changes in fluid and electrolyte concentration, and amount of adipose tissue
What are the two things in blood?
Formed elements and liquid portion
What falls under formed elements
Erthrocytes, leukocytes, thrombocytes
What falls under liquid portion
Plasma
Percentage of RBC is called
Hematocrit (HCT)
Packed cell volume (PCV)
What is the breakdown of formed elements
Platelets, red blood cells, white blood cells
What is the breakdown of white blood cells
Neutrophils, eosinophils, basophils, monocytes, lymphocytes
What is the breakdown of plasma
Electrolytes, water, proteins, wastes, nutrients, gases
What is the breakdown of nutrients
Vitamins and hormones
What is the breakdown of gases
N2, O2, CO2
What is the breakdown of proteins
Albumins, globulins, fibrinogen
Viscosity
Resistance of a fluid to flow; thickness
Osmolarity
Total molarity of dissolved particles that cannot pass through the blood vessel wall
Hematopoiesis
Formation of blood cells
Blood cells originate in
Red bone marrow from hematopoietic stem cells
Hematopoietic growth factors cause what
Hematopoietic stem cells to differentiated
Lymphoid stem cells
Lymphocytes
Myeloid stem cells
RBC, other types of WBC & platelets
What do red blood cells NOT have
Nuclei & mitochondria
RBC is what
1/3 hemoglobin by volume (gives blood it’s color
What is the function of hemoglobin
Carry O2 & CO2 and buffers blood pH
Hemoglobin plus O2
Oxyhemoglobin (red)
Hemoglobin plus released O2
Deoxyhemoglobin (dark blue)
What is the composition of hemoglobin
4 globing protein chains& 4 heme groups that transport 1 O2 molecule each
Red blood cell count
Number of RBCs in a cubic millimeter or microliter of blood
What is the purpose of red blood cell count
Diagnosis of diseases and evaluation of their progress and it changes reflect changes in bloods oxygen carrying capacity
Low blood O2 causes what
Kidneys and liver to release EPO and stimulates RBC production
Negative feedback mechanism for erythrocytes
High altitudes, loss of blood, and chronic lung disease
Hypoxemia
Oxygen deficiency in blood
Vitamin B12 and folic acid
DNA synthesis; growth & division of all cells
Iron
Hemoglobin synthesis
Anemia
Deficiency of RBCs or a reduction in amount of hemoglobin they contain
Leukocytes
Protect against disease and produces red bone marrow, under control of hormones
What are the 5 types of WBCs in 2 different categories
Granulocytes
Neutrophils
Eosinophils
Basophils
Agranulocytes
Lymphocytes
Monocytes
Granulocytes
Have granular cytoplasm
Agranulocytes
Do not have noticeable granules
Neutrophils
Most abundant, small and light purple granules. Lobed nucleus: 2-5 sections and first to arrive at infection site.
What is the function of neutrophils
Phagocytize bacteria, fungi & some viruses
Eosinophils
Coarse granules; stain deep red & bi-lobed nucleus
What is the function of eosinophils
Moderate allergic reactions and defend against parasite worm infestations
Basophils
Large granules; stain deep blue and granules can obscure nucleus
What is the function of basophils
Migrate to damaged tissue.
Releasing histamine is to what
Stimulate inflammation
Releasing heparin is to what
To stop blood from clotting
Monocytes
Largest of WBC & spherical, kidney-shaped, oval or lobed nuclei and leaves bloodstream to become macrophages
What is the function of monocytes
Phagocytize bacteria, dead cells, debris
Lymphocytes
Slightly larger than RBCs; smallest WBCs and large spherical nucleus surrounded by thin rim of cytoplasm
What is the function of lymphocytes
T cells & B cells are major types. T cells directly attack pathogens, tumor cells, and transplanted cells.
Diapedesis
Leave blood vessel & go to infection site/injury
Phagocytosis
Engulfing & digestion of pathogens (neutrophils & monocytes)
Inflammatory response
Reaction that restricts spread of infection; promoted by basophils, involves swelling & increased capillary permeability
Positive chemotaxis
Attraction of WBCs to an infection site, by chemicals released by damaged cells
White blood cell count
3,500-10,500/mm3 of blood
Leukocytosis
High WBC count; acute infection, vigorous exercise, great loss of body fluids, emotional disturbances
Leukopenia
Low WBC count; typhoid fever, flu, measles, mumps, chicken pox, AIDS, polio, anemia and poisoning
Differential WBC count
Lists percentages of types of leukocytes and percentages may change in particular.
What is the function of platelets
Vasoconstriction, platelet plug, release clotting factors, and internalize & destroy bacteria
Blood plasma
Clear, straw- colored, liquid portion of blood, 55% of blood volume, 92% water plus organic and inorganic chemicals
What is the function of plasma
Transports nutrients, gases, hormones, & vitamins. Helps regulate fluid & electrolyte balance & maintain pH
What are the 3 main types of plasma proteins
Albumins
Globulins
Fibrinogen
Albumin
Smallest (60%)
What synthesizes albumin
Liver
What is the function of albumin
Determinant of osmotic pressure-> control blood volume -> BP
Transports solutes
Globulins
35%; alpha, beta, and gamma globulins
What is the synthesis of globulins
Liver: alpha and beta
Lymphatic tissue: gamma
What is the function of globulins
Alpha & beta: transport lipids & fat soluble vitamins
Gamma: antibodies in immune system
What is the synthesis of fibrinogen
Liver
What is the function of fibrinogen
Blood coagulation
Most important blood gases
Oxygen & carbon dioxide
What falls under plasma nutrients
Amino acids, simple sugars, nucleotides and lipids
What are molecules that contain nitrogen, but are not proteins
Urea, Unix acid, amino acids, creatine, creatinine
What do hormones do
Target cells and organs
What are the functions of hormones
- regulate metabolic processes
- control rates of chemical reactions
- aid in transporting substances through membranes
- regulate water & electrolyte balance
- regulate BP
What roles do hormones play part in?
Reproduction
Development
Growth
Cascade effect
One effect on another and another
Glandular cells
Secrete hormones into bloodstream
Where is pituitary gland located
Hypophysis (bass of the brain) attaches to hypothalamus by pituitary stalk or infundibulum
Anterior lobe
Enclosed by connective & epithelial tissue & has 5 types of secretory cells that release a specific hormone
Posterior lobe
Does not synthesize hormones; part of nervous system
2 associates hormones & are stored in vesicles in neurosecretory cells
Anterior lobe consist of?
Glandular cells & is under hypothalamus control
Axon terminals of hypothalamic neurons released what
Chemicals called releasing hormones
Releasing hormones are directly carried in the blood vis what?
Capillary beds associated with the hypothalamus and anterior lobe
What is the posterior lobe part of
Nervous system
Posterior lobe axons of certain neurons whose cell bodies are in what?
Hypothalamus extend down into the posterior pituitary gland
Posterior lobe hormones are transported down what
Down axons to the posterior pituitary & are stored in vesicles near the ends of the axons
Posterior lobe impulses on the the axons trigger the release of what
Chemicals from their axon terminals, which then enter the bloodstream as posterior pituitary hormones
What are the stimulated hormones
- thyrotropin- releasing hormone
- corticotropin- releasing
- gonadotropin releasing
- growth hormone releasing
Thyrotropin releasing hormone (TRH)
Promotes thyroid- stimulating hormone & prolactin
Corticotropin releasing hormone
Promotes adrenocotropin hormone
Gonadotropin releasing hormone
Promotes follicles stimulating hormone & luteinizing hormone
Growth releasing hormone
Promotes growth hormone
What are the inhibited hormones
Prolactin (PIH) & somatostatin
Prolactin- inhibiting hormone
Inhibits prolactin
Somatostatin
Inhibits growth hormone & thyroid stimulating hormone
What were the anterior pituitary hormones
- follicle stimulating hormone (FSH)
- luteinizing hormone (LH)
- thyroid- stimulating hormone (TSH)
- adrenocorticotropic hormone (ACTH)
- prolactin (PRL)
- growth hormone ( GH)
Follicle stimulating hormones
- ovaries growth of ovulation follicles& secretion of estrogen
- testes- sperm production
Luteinizing hormone
Ovaries- ovulation
Testes- testosterone secretion
Thyroid stimulating hormone
Thyroid gland
Growth of thyroid; secretion of thyroid hormones
Adrenocorticotropic hormone
Adrenal cortex
Growth of adrenal cortex , secretion of glucocorticoids
Prolactin
Mammary glands & milk synthesis
Growth hormone
Liver, bone, cartilage, muscle and fat
Tissue growth- mitosis
Posterior pituitary hormones
Antidiuretic hormones (ADH)
Oxytocin (OT)