Test One Flashcards
What are the functions of blood
Transport, Protection, Regulation
Define volume of blood
Varies with body size, changes in fluid and electrolyte concentration, and amount of adipose tissue
What are the two things in blood?
Formed elements and liquid portion
What falls under formed elements
Erthrocytes, leukocytes, thrombocytes
What falls under liquid portion
Plasma
Percentage of RBC is called
Hematocrit (HCT)
Packed cell volume (PCV)
What is the breakdown of formed elements
Platelets, red blood cells, white blood cells
What is the breakdown of white blood cells
Neutrophils, eosinophils, basophils, monocytes, lymphocytes
What is the breakdown of plasma
Electrolytes, water, proteins, wastes, nutrients, gases
What is the breakdown of nutrients
Vitamins and hormones
What is the breakdown of gases
N2, O2, CO2
What is the breakdown of proteins
Albumins, globulins, fibrinogen
Viscosity
Resistance of a fluid to flow; thickness
Osmolarity
Total molarity of dissolved particles that cannot pass through the blood vessel wall
Hematopoiesis
Formation of blood cells
Blood cells originate in
Red bone marrow from hematopoietic stem cells
Hematopoietic growth factors cause what
Hematopoietic stem cells to differentiated
Lymphoid stem cells
Lymphocytes
Myeloid stem cells
RBC, other types of WBC & platelets
What do red blood cells NOT have
Nuclei & mitochondria
RBC is what
1/3 hemoglobin by volume (gives blood it’s color
What is the function of hemoglobin
Carry O2 & CO2 and buffers blood pH
Hemoglobin plus O2
Oxyhemoglobin (red)
Hemoglobin plus released O2
Deoxyhemoglobin (dark blue)
What is the composition of hemoglobin
4 globing protein chains& 4 heme groups that transport 1 O2 molecule each
Red blood cell count
Number of RBCs in a cubic millimeter or microliter of blood
What is the purpose of red blood cell count
Diagnosis of diseases and evaluation of their progress and it changes reflect changes in bloods oxygen carrying capacity
Low blood O2 causes what
Kidneys and liver to release EPO and stimulates RBC production
Negative feedback mechanism for erythrocytes
High altitudes, loss of blood, and chronic lung disease
Hypoxemia
Oxygen deficiency in blood
Vitamin B12 and folic acid
DNA synthesis; growth & division of all cells
Iron
Hemoglobin synthesis
Anemia
Deficiency of RBCs or a reduction in amount of hemoglobin they contain
Leukocytes
Protect against disease and produces red bone marrow, under control of hormones
What are the 5 types of WBCs in 2 different categories
Granulocytes
Neutrophils
Eosinophils
Basophils
Agranulocytes
Lymphocytes
Monocytes
Granulocytes
Have granular cytoplasm
Agranulocytes
Do not have noticeable granules
Neutrophils
Most abundant, small and light purple granules. Lobed nucleus: 2-5 sections and first to arrive at infection site.
What is the function of neutrophils
Phagocytize bacteria, fungi & some viruses
Eosinophils
Coarse granules; stain deep red & bi-lobed nucleus
What is the function of eosinophils
Moderate allergic reactions and defend against parasite worm infestations
Basophils
Large granules; stain deep blue and granules can obscure nucleus
What is the function of basophils
Migrate to damaged tissue.
Releasing histamine is to what
Stimulate inflammation
Releasing heparin is to what
To stop blood from clotting
Monocytes
Largest of WBC & spherical, kidney-shaped, oval or lobed nuclei and leaves bloodstream to become macrophages
What is the function of monocytes
Phagocytize bacteria, dead cells, debris
Lymphocytes
Slightly larger than RBCs; smallest WBCs and large spherical nucleus surrounded by thin rim of cytoplasm
What is the function of lymphocytes
T cells & B cells are major types. T cells directly attack pathogens, tumor cells, and transplanted cells.
Diapedesis
Leave blood vessel & go to infection site/injury
Phagocytosis
Engulfing & digestion of pathogens (neutrophils & monocytes)
Inflammatory response
Reaction that restricts spread of infection; promoted by basophils, involves swelling & increased capillary permeability
Positive chemotaxis
Attraction of WBCs to an infection site, by chemicals released by damaged cells
White blood cell count
3,500-10,500/mm3 of blood
Leukocytosis
High WBC count; acute infection, vigorous exercise, great loss of body fluids, emotional disturbances
Leukopenia
Low WBC count; typhoid fever, flu, measles, mumps, chicken pox, AIDS, polio, anemia and poisoning
Differential WBC count
Lists percentages of types of leukocytes and percentages may change in particular.
What is the function of platelets
Vasoconstriction, platelet plug, release clotting factors, and internalize & destroy bacteria
Blood plasma
Clear, straw- colored, liquid portion of blood, 55% of blood volume, 92% water plus organic and inorganic chemicals
What is the function of plasma
Transports nutrients, gases, hormones, & vitamins. Helps regulate fluid & electrolyte balance & maintain pH
What are the 3 main types of plasma proteins
Albumins
Globulins
Fibrinogen
Albumin
Smallest (60%)
What synthesizes albumin
Liver
What is the function of albumin
Determinant of osmotic pressure-> control blood volume -> BP
Transports solutes
Globulins
35%; alpha, beta, and gamma globulins
What is the synthesis of globulins
Liver: alpha and beta
Lymphatic tissue: gamma
What is the function of globulins
Alpha & beta: transport lipids & fat soluble vitamins
Gamma: antibodies in immune system
What is the synthesis of fibrinogen
Liver
What is the function of fibrinogen
Blood coagulation
Most important blood gases
Oxygen & carbon dioxide
What falls under plasma nutrients
Amino acids, simple sugars, nucleotides and lipids
What are molecules that contain nitrogen, but are not proteins
Urea, Unix acid, amino acids, creatine, creatinine
What do hormones do
Target cells and organs
What are the functions of hormones
- regulate metabolic processes
- control rates of chemical reactions
- aid in transporting substances through membranes
- regulate water & electrolyte balance
- regulate BP
What roles do hormones play part in?
Reproduction
Development
Growth
Cascade effect
One effect on another and another
Glandular cells
Secrete hormones into bloodstream
Where is pituitary gland located
Hypophysis (bass of the brain) attaches to hypothalamus by pituitary stalk or infundibulum
Anterior lobe
Enclosed by connective & epithelial tissue & has 5 types of secretory cells that release a specific hormone
Posterior lobe
Does not synthesize hormones; part of nervous system
2 associates hormones & are stored in vesicles in neurosecretory cells
Anterior lobe consist of?
Glandular cells & is under hypothalamus control
Axon terminals of hypothalamic neurons released what
Chemicals called releasing hormones
Releasing hormones are directly carried in the blood vis what?
Capillary beds associated with the hypothalamus and anterior lobe
What is the posterior lobe part of
Nervous system
Posterior lobe axons of certain neurons whose cell bodies are in what?
Hypothalamus extend down into the posterior pituitary gland
Posterior lobe hormones are transported down what
Down axons to the posterior pituitary & are stored in vesicles near the ends of the axons
Posterior lobe impulses on the the axons trigger the release of what
Chemicals from their axon terminals, which then enter the bloodstream as posterior pituitary hormones
What are the stimulated hormones
- thyrotropin- releasing hormone
- corticotropin- releasing
- gonadotropin releasing
- growth hormone releasing
Thyrotropin releasing hormone (TRH)
Promotes thyroid- stimulating hormone & prolactin
Corticotropin releasing hormone
Promotes adrenocotropin hormone
Gonadotropin releasing hormone
Promotes follicles stimulating hormone & luteinizing hormone
Growth releasing hormone
Promotes growth hormone
What are the inhibited hormones
Prolactin (PIH) & somatostatin
Prolactin- inhibiting hormone
Inhibits prolactin
Somatostatin
Inhibits growth hormone & thyroid stimulating hormone
What were the anterior pituitary hormones
- follicle stimulating hormone (FSH)
- luteinizing hormone (LH)
- thyroid- stimulating hormone (TSH)
- adrenocorticotropic hormone (ACTH)
- prolactin (PRL)
- growth hormone ( GH)
Follicle stimulating hormones
- ovaries growth of ovulation follicles& secretion of estrogen
- testes- sperm production
Luteinizing hormone
Ovaries- ovulation
Testes- testosterone secretion
Thyroid stimulating hormone
Thyroid gland
Growth of thyroid; secretion of thyroid hormones
Adrenocorticotropic hormone
Adrenal cortex
Growth of adrenal cortex , secretion of glucocorticoids
Prolactin
Mammary glands & milk synthesis
Growth hormone
Liver, bone, cartilage, muscle and fat
Tissue growth- mitosis
Posterior pituitary hormones
Antidiuretic hormones (ADH)
Oxytocin (OT)
Antidiuretic hormone
Kidney & water retention
Oxytocin
Uterus ; mammary glands & labor contractions (milk release) and other functions
Where is the thyroid gland
Below larynx ; both sides & anterior to trachea
What are the structures of thyroid gland?
2 large vascularized lines connected by a board isthmus; covered by a CT capsule & composed of thyroid follicles
Follicular cells
Lines the follicles ( simple cuboidal epithelial cells)
Extracfollicular/ paragollicular cells
Cells that lie outside of the follicle; colloid fills the cavities, which consists of thoyogloblin
What are the hormones produced by thyroid glands
Thyroxine (T4)
Triiodothyonime (T3)
Calcitonin
What is T4 & T3 synthesize & by what
Follicular cells
What is the function of T4 & T3?
Increases rate of energy release from carbohydrates
Increases rate of protein synthesis
Stimulates breakdown of lipids
Accelerated growth
Stimulates activity in the nervous system
Determines how many calories the body must overcome
What is the source of control for T4 & T3
TSH from anterior pituitary gland.
T3: 5x more potent than T4 & is more prevalent
Calcitonin is synthesized by what
Extrafollicular cells
What are the functions of calcitonin
Lower blood calcium & phosphate ion concentration
- inhibits release of calcium & phosphate ions from bones (osteoclasts)
- increases rate at which calcium & phosphates ions are deposited in bones ( osteoblasts)
Increases excretion of calcium by kidneys
Calcitonin source of control
Elevated blood calcium ion concentration, digestive hormones
What is the location of parathyroid gland
Posterior surface of thyroid gland & superior & inferior & on both sides of thyroid
What is the structure of parathyroid gland?
Small yellow-brown sturctures
Covered by CT
Composed of secretory cells
What falls under parathyroid hormone
Bones, kidneys, intestines
Parathyroid hormone bones
Stimulates bone resorption by osteoclasts & inhibits osteoblasts
Parathyroid hormone kidney
Cause kidneys to conserve blood calcium ions & to excrete more phosphate ions in urine
Parathyroid hormone intestines
Indirectly stimulates absorption of calcium ions from flood in the intestine by influencing metabolism of vitamin D
Parathyroid hormone
Increases blood calcium ion concentration & decreases blood phosphate ion concentration through actions in the bones, kidneys, & intestines.
Homeostasis
Trying to maintain calcium ion concentration
Calcitonin & PTH are antagonistic
What is location of adrenal gland
Close association with kidneys
Sits atop of kidneys
Embedded in adipose tissue
What is the structure of adrenal gland
Pyramid shaped and vascularized
What are the 2 parts of adrenal gland
Adrenal medulla & adrenal cortex
What are the layers of adrenal glands
Adrenal medulla (inner core)
Adrenal cortex (outer layer)
Chromaffin cells
Grouped around blood vessels & connected with sympathetic division of automatic nervous system
What are the 3 layers of adrenal cortex?
Outer (zona glomerulosa)
Middle (zona fasciculata)
Inner (zona reticularis)
What are the effects of hormones of the adrenal medulla
- Increase heart rate
- Increases force of cardiac muscle contraction
- Increased breathing rate
- Increased BP
- Decreased digestive activity
What are the hormones of the adrenal cortex
Aldosterone (zona glomerulosa)
Cortisol (zona fasciculata)
Adrenal androgens (zona reticularis)
What is the action & target of aldosterone
Helps regulate the concentration of extra cellular electrolytes by conserving sodium ions (retaining water) & excreting potassium ions
Kidneys
What does aldosterone regulate
Electrolyte concentrations in body fluids & blood pressure & volume
What is the action & target of cortisol
Decreases protein synthesis, increases fatty acid release, & stimulates glucose synthesis from non carbohydrates (when blood glucose levels are low)
Any tissues
What is the regulations of cortisol
CRH from the hypothalamus & ACTH from the anterior pituitary gland
What is the action & target of adrenal androgens?
Supplement sex hormones from the gonads; may be converted into estrogens
Many tissues
What is the location of pancreas
Posterior to stomach
What is the structure of the pancreas
Pancreatic duct attaches to the duodenum transporting digestive juices into the intestine (exocrine function)
What falls under pancreatic islets
Alpha cells (glucagon)
Beta cells (insulin)
Delta cells (somatostatin)
What is the function of glucagon : alpha cells?
Stimulates liver to break down glycogen into glucose (glycolysis) & to convert non-carbohydrates into glucose (gluconegenesis)
Stimulates breakdown of fats into fatty acids & glycerol
In glucagon low blood glucose concentration stimulates release of what?
Decreases blood glucose concentration; stimulates liver to form glycogen from glucose & inhibits conversion of non-carbohyduinto glucose.
Stimulates adipose cells to synthesize & store fat
Somatostatin? Delta cells?
Helps regulate glucose metabolism by inhibiting secretion of glucagon & insulin
What does pineal gland secrete?
Melatonin
What is the function of pineal gland?
Part of regulating circadian rhythms- patterns of repeated activity associated with cycles of night & day
What is pineal gland controlled by?
Light & dark patterns outside the body
What is thymus secreted by
Thymosins
What is thymus function
Affect production & differentiation of white blood cells; immunity
Gonads
Reproductive system
What are the 3 chemical class
Steroid hormones
Monoamines
Peptide hormones
Define steroid hormones
Derived from cholesterol & synthesized in gonads & adrenal cortex
Define monoamines
Synthesized from amino acids
Define peptide hormones
3 or more amino acids
Define neural stimuli
Gland stimulated by nerve fibers
Define hormonal stimuli
Hormones stimulate other glands
Define humoral stimuli
Blood-borne stimuli
Hormone secretion
Not secreted at steady rates & levels vary
Hormone transport
Arrive at target cell via blood stream
Hydrophilic hormones
Monoamines & peptides
Hydrophobic hormone
Steroids & thyroid hormone
Bound hormone
Attached
Unbound hormone
Unattached
Hormones can only act as what
Target cells
Receptors location
Plasma membrane
Cytoplasm
Nucleus
Specificity
Receptor to one hormone
Saturation
All receptors are bound by a hormone
Define steroid hormone
Poorly soluble in water & double in hydrophobic portion of cell membranes; diffuse easily through
Define thyroid hormones
Also poorly soluble in water & specific membrane transport mechanisms
Once inside a target cell it does what
Steroid & thyroid hormones combine with specific protein receptors to form a hormone-receptor complex
Hormone receptor complex binds
To particular DNA sequences
What is the hormone that triggers this first step is considered
First messenger
Define second messengers
Amplify the cellular responses to a hormone & can be activated in response to just a few hormone receptor complexes
Up- regulation
A cell increases the # of hormones receptors & more sensitive to hormone
Down regulation
A cell reduces the # of hormone receptors, less sensitive to hormone & long term exposure to high hormone concentration
Fluid recovery
Reabsorb & return leaked fluid to blood
Immunity
Fluid passes through lymph node
Lupus absorption
Lacteals absorb dietary lipids
Lymph
Fluid derived from the interstitial fluid that the lymphatic vessels carry
Interstitial fluid
Fluid that surround cells
Lymphatic capillaries description
Microscopic, closed ended tubes that extend into interstitial spaces
What is the location of lymphatic capillaries
Everywhere except bone, bone marrow, and corneas & close association with blood capillaries
Lymphatic vessels composed of 3 layers
Endothelial lining, smooth muscle and elastic fibers & CT
Internal valves
Prevent backflow
Lumbar trunk
Lower limbs
Intestinal trunk
Abdominal viscera
Intercostal & bronchomediastinal trunk
Thorax
Subclavian trunk
Upper limbs
Jugular trunk
Neck & head
Thoracic duct
Largest; originates as an enlarged sac in the abdomen & passes upward through diaphragm beside the aorta & empties into the left subclavian vein
Cisterns chlyi
Originates as an enlarged sac in the abdomen
Drains lymph
Intestinal, lumbar, intercostal, left subclavian, left jugular, left bronchomediastinal trunks
Right lymphatic duct
Originates in the right thorax at the union of the right jugular, subclavian and bronchomediastinal trunks
When does tissue fluid formation occurs when
Capillary blood pressure filters water and small molecules from the plasma
Lymph formation
Filtration normally exceeds reabsorption-> tissue fluid formation
What are 3 ways to help move lymph
- Contracting skeletal muscles in limbs.
- Contracting smooth muscle in lymphatic trunks
- Pressure changes from skeletal muscle used in breathing
When would lymph flow peak? Why?
Valves in lymphatic vessels help prevent backflow and keep fluid moving onward
Lymph function
Absorption of dietary fats & returns small proteins back to bloodstream.
Transport of foreign particles to lymph nodes
Lymphocytes
T lymphocytes (T cells)
B lymphocytes (B cells)
Macrophages
Phagocytizing cells
Dendritic cells
Capture antigens & bring them back to lymph nodes
Reticular cells
Produce reticular fibers
Lymphoid tissue
House and provide a proliferation site for lymphocytes
Furnishes an ideal surveillance vantage point for lymphocytes and macrophages
What is lymphoid tissue composed of
Reticular CT
Diffuse lymphoid tissue
Loose arrangement of lymphoid cells and reticular fibers
MALT
Mucosa Associated Lymphoid Tissue
What is diffused lymphoid tissue exposed to exterior
Digestive, respiratory, urinary, & reproductive
What is lymphoid nodules also called
Follicles
Lymphoid nodules
Solid, spherical bodies of tightly packed lymphoid cells and reticular fibers
What is the location of lymphoid nodules
Lymph nodes, tonsils, appendix, & ilium
Primary lymphoid organs
T & B lymphocytes go to mature
Red bone marrow
B cells
Thymus
T cells
Secondary lymphoid organs
Where mature lymphocytes first encounter antigens and are activated
Lymph nodes
Cluster along lymphatic vessels & are a large groupings near body surfaces in the i GUI also, ancillary and cervical regions
What are the 2 basic protective functions of the lymph nodes
- Cleanse lymph
2. Immune system activation
Cleanse lymph
Macrophages
Immune system activation
Lymphocytes encounter antigens & become activated
Trabeculae
CT from capsule extends inward & divides the node into compartments
What are the 2 distinct regions of the lymph node structure
Cortex & medulla
Cortex
Lymphoid nodules with germinal center
Medullla
Medullary cords (onward extension of cortical tissue)
Lymph sinuses
Lymphatic capillaries
Location of the thymus
Mediastinum, anterior to aortic arch, and posterior to upper part of the body of sternum
Location of spleen
Upper, left portion of the abdominal cavity
What does the spleen help do
Helps to filter blood
What are the 2 type of tissues in spleen
White pulp and red pulp
Hilum
Blood vessels & nevrous enter
White pulp
Lymphocytes & macrophages
Red pulp
Sinuses with erythrocytes
Pathogen
Disease causing agent
What are the 2 defense systems the body uses against infection
- Innate defense
2. Adaptive defense
Innate defense
No specific, local & lacks memory
Adaptive defense
Lines of defense
Innate defenses
Species resistance Mechanical barriers Inflammation Chemical barriers Natural killer cells Phagocytosis Fever
Helper T cell
Stimulate a type of B cell to produce antibodies
Cytotoxic T cell
Recognize and eliminate tumor cells and virus infected cells
Memory T cell
“Remember” antigen if subsequent exposure occurs
Cytokinesis
Polypeptide that enhances certain cellular responses to antigens
Perforins
Protein that cuts pore like openings in cells , destroying them
What are the T cell secretions
Cytokinesis & perforins
Plasma cells produce and secrete what
Antibodies
Antibody molecules
5 types of antibodies
Y shape
4 amino acid or polypeptide chain
Variable region
Specialized to fit shape of a specific antigen molecule
Constant region
Not going to change; give antibody certain properties
What are the types of immunoglobulins
Ig G Ig A Ig M Ig D Ig E
What is the location of Ig G and what is it effective against
Location- plasma and tissue fluid
Effective against- bacteria, viruses& toxins
What is the location of Ig A and what is it effective against
Location- exocrine gland secretions
Effective against- bacteria & viruses
I hat is the location of Ig M and what is it effective against
Location - plasma
Effective against- certain antigens in foods or bacteria
What is the location of Ig D
Location- surface of most B cells
What is the location of Ig E
Exocrine gland secretion
Antibody actions do what
Direct attack, complement activation , and localized changes
Agglutination
Antigens clump
Precipitation
Form insoluble substances
Neutralization
Antigen loses toxic properties
Opsonization
Antibody- antigen complex more susceptible to phagocytosis
Chemotaxis
Attracts macrophages & neutrophils
Primary immune response
Occurs when B and T cells become activated after first encountering antigens
Secondary immune response
Subsequent encounter of a previous antigen