Test 5: Anti arrhythmic Med Chem Flashcards
What is this particular functional group in quinidine?
A. Vinyl
B. Aryl
C. Quinoline Ring
D. Quinuclidine
A
What is the name of this functional group in Quinidine?
A. Vinyl
B. Aryl
C. Quinuclidine
D. Quinoline Ring
C
What is the name of this particular structure in Quinidine?
A. Vinyl
B. Aryl
C. Quinuclidine
D. Quinoline Ring
D
Based on the pKa value of the nitrogen, quinidine is is considered a ____ drug and can form a salt when exposed to a ____.
A. Acid, Base
B. Base, Acid
B
Which statements are true regarding the drug quinidine?
A. Vinyl group can undergo oxidation
B. The CH3O group on the quiniline ring can undergo O-demethylation
C. Quinidine is a PgP inhibitor
D. Quinidine is a CYP2D6 inhibitor
E. All of the above
E
Since Quinidine is a PgP inhibitor it will ____ concentrations of digoxin in the body when given together.
A. Increase
B. Decrease
A
Quinidine is also a CYP2D6 inhibitor and when given with Codeine it will ____ the therapetutic effects of Codeine.
A. Intensify
B. Diminish
B
Codeine is a prodrug that requires activation via the CYP2D6 enzymes. If you give quinidine with codeine then quinidine will inhibit the enzyme CYP2D6 and stop lower the activation of codeine and diminish the therapeutic effects of codeine.
When comparing Procaine (different drug) to Procainamide (antiarrhythmatic) what can be said about their differences?
A. Procaine has an ester and Procainamide has an amide group
B. The amide group in Procainamide is less likely to undergo hydrolysis than the ester group in Procaine
C. Primary amine on the aryl group in procainamide can undergo acetylation and form the N-acetylprocainamide. Which also has antiarrhythmatic activity.
D. All of the above
D
The drug Procainamide can undergo ____ by using the _____ enzyme.
A. Glucuronidation, GLUT
B. Acetylation, N-Acetyl Transferase (NAT)
C. Acetylation, SULT
D. Glucuronidation, N-Acetyl Transferase (NAT)
B
Which of the following statements regarding Procainamide is true (Select All)?
A. It can cause drug-induced Lupus Erythematosus
B. The free amine on the aryl group (on the left) is the reason why drug-induced Lupus Erythematosus can occur
C. Drug-induced Lupus Erythematosus is more commonly seen in slow acetylators
D. All of the above
D
Which statements are true regarding Disopyramide? (Select All)
A. It contains an Amide functional group
B. It contains a Pyridine ring
C. It contains a secondary amine
D. it contains a tertiary amine
E. it contains an aryl group
A, B, D, E
The tertiary amine in disopyramide can undergo ____ to give rise to the
