Test #4 Review Questions Chapter 8 (Other Blood Groups) Flashcards
The following phenotypes are written incorrectly except for:
a. Jk^a+
b. Jka+
c. Jk^a(+)
d. Jk(a+)
d. Jk(a+)
Quiz Question*
Which of the following characteristics best describes Lewis antibodies?
a. IgM, naturally occurring antibodies, cause HDFN
b. IgM, naturally occurring antibodies, do not cause HDFN
c. IgG, in vitro hemolysis, cause hemolytic transfusion reactions
d. IgG, in vitro hemolysis, do not cause hemolytic transfusion reactions
b. IgM, naturally occurring antibodies, do not cause HDFN
The Le gene codes for a specific glycosyltransferase that transfers a glucose to the N-acetylglucosamine on:
a. Type 1 precursor chain
b. Type 2 precursor chain
c. Type 1 and 2 precursor chain
d. Either type 1 or type 2 in any one individual but not both
a. Type 1 precursor chain
Quiz Question*
What substances would be found in the saliva of a group B secretor who also has Lele genes?
a. H, Le^a
b. H, B, Le^a
c. H, B, Le^a, Le^b
d. H, B, Le^b
c. H, B, Le^a, Le^b
Transformation to Le^b phenotype after birth may be as follows:
a. Le(a-b-) to Le(a+b-) to Le(a+b+) to Le(a-b+)
b. Le(a+b-) to Le(a-b-) to Le(a-b+) to Le(a+b+)
c. Le(a-b+) to Le(a+b-) to Le(a+b+) to Le(a-b-)
d. Le(a+b+) to Le(a+b-) to Le(a-b-) to Le(a-b+)
a. Le(a-b-) to Le(a+b-) to Le(a+b+) to Le(a-b+)
In what way do the Lewis antigens change during pregnancy?
a. Le^a antigen increases only
b. Le^b antigen increases only
c. Le^a and Le^b both increase
d. Le^a and Le^b both decrease
d. Le^a and Le^b both decrease
Any type 1 chain has:
a. The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine
b. The terminal galactose in a 1-4 linkage to subterminal N-acetylglucosamine
c. The terminal galactose in a 1-3 linkage to subterminal N-acetylgalactosamine
d. The terminal galactose in a 1-4 linkage to subterminal N-acetylgalactosamine
a. The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine
Which of the following best describes Lewis antigens?
a. The antigens are integral membrane glycolipids
b. Le^a and Le^b are antithetical antigens
c. The Le(a+b-) phenotype is found in secretors
d. None of the above
NOT The antigens are integral membrane glycolipids
NOT Le^a and Le^b are antithetical antigens
NOT The Le(a+b-) phenotype is found in secretors
d. None of the above!
Which of the following genotypes would explain RBCs typed as group A Le(a+b-)?
a. A/O Lele HH Sese
b. A/A Lele HH sese
c. A/O LeLe hh SeSe
d. A/A LeLe hh sese
b. A/A Lele HH sese
Anti-Le^bH will not react or will react more weakly with which of the following RBCs?
a. Group O Le(b+)
b. Group A2 Le(b+)
c. Group A1 Le(b+)
d. None of the above
c. Group A1 Le(b+)
Which of the following best describes MN antigens and antibodies?
a. Well developed at birth, susceptible to enzymes, generally saline reactive
b. Not well developed at birth, susceptible to enzymes, generally saline reactive
c. Well developed at birth, not susceptible to enzymes, generally saline reactive
d. Well developed at birth, susceptible to enzymes, generally antiglobulin reactive
a. Well developed at birth, susceptible to enzymes, generally saline reactive
Quiz Question *
Which autoantibody specificity is found in patients with paroxysmal cold hemoglobinuria?
a. Anti-I
b. Anti-i
c. Anti-P
d. Anti-P1
c. Anti-P
Quiz Question *
Which of the following is the most common antibody seen in the blood bank after ABO and Rh antibodies?
a. Anti-Fy^a
b. Anti-k
c. Anti-Js^a
d. Anti-K
d. Anti-K
Quiz Question *
Which blood group system is associated with resistance to P. vivax malaria?
a. P
b. Kell
c. Duffy
d. Kidd
c. Duffy
The null Ko RBC can be artificially prepared by which of the following treatments?
a. Ficin and DTT
b. Ficin and glycine-acid EDTA
c. DTT and glycine-acid EDTA
d. Glycine-acid EDTA and sialidase
c. DTT and glycine-acid EDTA
Quiz Question *
Which antibody does NOT fit with the others with respect to optimum phase of reactivity?
a. Anti-S
b. Anti-P1
c. Anti-Fy^a
d. Anti-Jk^b
b. Anti-P1
Quiz Question *
Which of the following Duffy phenotypes is prevalent in blacks but virtually nonexistent in whites?
a. Fy(a+b+)
b. Fy(a-b+)
c. Fy(a-b-)
d. Fy(a+b-)
c. Fy(a-b-)
Antibody detection cells will NOT routinely detect which antibody specificity?
a. Anti-M
b. Anti-Kp^a
c. Anti-Fy^a
d. Anti-Lu^b
b. Anti-Kp^a
Antibodies to antigens in which of the following blood groups are known for showing dosage?
a. I
b. P
c. Kidd
d. Lutheran
c. Kidd (Jk)
Quiz Question*
Which antibody is most commonly associated with delayed hemolytic transfusion reactions?
a. Anti-s
b. Anti-k
c. Anti-Lu^a
d. Anti-Jk^a
d. Anti-Jk^a (Kidd)
Anti-U will not react with which of the following RBCs?
a. M+N+S+s-
b. M+N-S-s-
c. M-N+S-s+
d. M+N-S+s+
b. M+N-S-s-
A patient with an M. pneumoniae infection will most likely develop a cold autoantibody with specificity to which antigen?
a. I
b. i
c. P
d. P1
a. I
Quiz Question *
Which antigen is destroyed by enzymes?
a. P1
b. Js^a
c. Fy^a
d. Jk^a
c. Fy^a
The antibody to this high-prevalence antigen demonstrates mixed-field agglutination that appears shiny and refractive under the microscope:
a. Vel
b. JMH
c. Jr^a
d. Sd^a
d. Sd^a
