Test #4 Review Questions Chapter 8 (Other Blood Groups)

Question 1

The following phenotypes are written incorrectly except for:

a. Jk^a+
b. Jka+
c. Jk^a(+)
d. Jk(a+)

Answer 1

d. Jk(a+)

Question 2

Quiz Question*

Which of the following characteristics best describes Lewis antibodies?

a. IgM, naturally occurring antibodies, cause HDFN
b. IgM, naturally occurring antibodies, do not cause HDFN
c. IgG, in vitro hemolysis, cause hemolytic transfusion reactions
d. IgG, in vitro hemolysis, do not cause hemolytic transfusion reactions

Answer 2

b. IgM, naturally occurring antibodies, do not cause HDFN

Question 3

The Le gene codes for a specific glycosyltransferase that transfers a glucose to the N-acetylglucosamine on:

a. Type 1 precursor chain
b. Type 2 precursor chain
c. Type 1 and 2 precursor chain
d. Either type 1 or type 2 in any one individual but not both

Answer 3

a. Type 1 precursor chain

Question 4

Quiz Question*

What substances would be found in the saliva of a group B secretor who also has Lele genes?

a. H, Le^a
b. H, B, Le^a
c. H, B, Le^a, Le^b
d. H, B, Le^b

Answer 4

c. H, B, Le^a, Le^b

Question 5

Transformation to Le^b phenotype after birth may be as follows:

a. Le(a-b-) to Le(a+b-) to Le(a+b+) to Le(a-b+)
b. Le(a+b-) to Le(a-b-) to Le(a-b+) to Le(a+b+)
c. Le(a-b+) to Le(a+b-) to Le(a+b+) to Le(a-b-)
d. Le(a+b+) to Le(a+b-) to Le(a-b-) to Le(a-b+)

Answer 5

a. Le(a-b-) to Le(a+b-) to Le(a+b+) to Le(a-b+)

Question 6

In what way do the Lewis antigens change during pregnancy?

a. Le^a antigen increases only
b. Le^b antigen increases only
c. Le^a and Le^b both increase
d. Le^a and Le^b both decrease

Answer 6

d. Le^a and Le^b both decrease

Question 7

Any type 1 chain has:

a. The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine
b. The terminal galactose in a 1-4 linkage to subterminal N-acetylglucosamine
c. The terminal galactose in a 1-3 linkage to subterminal N-acetylgalactosamine
d. The terminal galactose in a 1-4 linkage to subterminal N-acetylgalactosamine

Answer 7

a. The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine

Question 8

Which of the following best describes Lewis antigens?

a. The antigens are integral membrane glycolipids
b. Le^a and Le^b are antithetical antigens
c. The Le(a+b-) phenotype is found in secretors
d. None of the above

Answer 8

NOT The antigens are integral membrane glycolipids

NOT Le^a and Le^b are antithetical antigens

NOT The Le(a+b-) phenotype is found in secretors

d. None of the above!

Question 9

Which of the following genotypes would explain RBCs typed as group A Le(a+b-)?

a. A/O Lele HH Sese
b. A/A Lele HH sese
c. A/O LeLe hh SeSe
d. A/A LeLe hh sese

Answer 9

b. A/A Lele HH sese

Question 10

Anti-Le^bH will not react or will react more weakly with which of the following RBCs?

a. Group O Le(b+)
b. Group A2 Le(b+)
c. Group A1 Le(b+)
d. None of the above

Answer 10

c. Group A1 Le(b+)

Question 11

Which of the following best describes MN antigens and antibodies?

a. Well developed at birth, susceptible to enzymes, generally saline reactive
b. Not well developed at birth, susceptible to enzymes, generally saline reactive
c. Well developed at birth, not susceptible to enzymes, generally saline reactive
d. Well developed at birth, susceptible to enzymes, generally antiglobulin reactive

Answer 11

a. Well developed at birth, susceptible to enzymes, generally saline reactive

Question 12

Quiz Question *

Which autoantibody specificity is found in patients with paroxysmal cold hemoglobinuria?

a. Anti-I
b. Anti-i
c. Anti-P
d. Anti-P1

Answer 12

c. Anti-P

Question 13

Quiz Question *

Which of the following is the most common antibody seen in the blood bank after ABO and Rh antibodies?

a. Anti-Fy^a
b. Anti-k
c. Anti-Js^a
d. Anti-K

Answer 13

d. Anti-K

Question 14

Quiz Question *

Which blood group system is associated with resistance to P. vivax malaria?

a. P
b. Kell
c. Duffy
d. Kidd

Answer 14

c. Duffy

Question 15

The null Ko RBC can be artificially prepared by which of the following treatments?

a. Ficin and DTT
b. Ficin and glycine-acid EDTA
c. DTT and glycine-acid EDTA
d. Glycine-acid EDTA and sialidase

Answer 15

c. DTT and glycine-acid EDTA

Question 16

Quiz Question *

Which antibody does NOT fit with the others with respect to optimum phase of reactivity?

a. Anti-S
b. Anti-P1
c. Anti-Fy^a
d. Anti-Jk^b

Answer 16

b. Anti-P1

Question 17

Quiz Question *

Which of the following Duffy phenotypes is prevalent in blacks but virtually nonexistent in whites?

a. Fy(a+b+)
b. Fy(a-b+)
c. Fy(a-b-)
d. Fy(a+b-)

Answer 17

c. Fy(a-b-)

Question 18

Antibody detection cells will NOT routinely detect which antibody specificity?

a. Anti-M
b. Anti-Kp^a
c. Anti-Fy^a
d. Anti-Lu^b

Answer 18

b. Anti-Kp^a

Question 19

Antibodies to antigens in which of the following blood groups are known for showing dosage?

a. I
b. P
c. Kidd
d. Lutheran

Answer 19

c. Kidd (Jk)

Question 20

Quiz Question*

Which antibody is most commonly associated with delayed hemolytic transfusion reactions?

a. Anti-s
b. Anti-k
c. Anti-Lu^a
d. Anti-Jk^a

Answer 20

d. Anti-Jk^a (Kidd)

Question 21

Anti-U will not react with which of the following RBCs?

a. M+N+S+s-
b. M+N-S-s-
c. M-N+S-s+
d. M+N-S+s+

Answer 21

b. M+N-S-s-

Question 22

A patient with an M. pneumoniae infection will most likely develop a cold autoantibody with specificity to which antigen?

a. I
b. i
c. P
d. P1

Answer 22

a. I

Question 23

Quiz Question *

Which antigen is destroyed by enzymes?

a. P1
b. Js^a
c. Fy^a
d. Jk^a

Answer 23

c. Fy^a

Question 24

The antibody to this high-prevalence antigen demonstrates mixed-field agglutination that appears shiny and refractive under the microscope:

a. Vel
b. JMH
c. Jr^a
d. Sd^a

Answer 24

d. Sd^a

Question 25

Which of the following has been associated with causing severe immediate HTRs?

a. Anti-JMH
b. Anti-Lu^b
c. Anti-Vel
d. Anti-Sd^a

Answer 25

c. Anti-Vel

Question 26

Which of the following antibodies would more likely be found in a black patient?

a. Anti-Cr^a
b. Anti-At^a
c. Anti-Hy
d. All of the above

Answer 26

YES Anti-Cr^a

YES Anti-At^a

YES Anti-Hy

d. All of the above!

Question 27

Which of the following antigens is not in a blood group system?

a. Do^a
b. Vel
c. JMH
d. Kx

Answer 27

b. Vel

Question 28

A weakly reactive antibody with a titer of 128 is neutralized by plasma. Which of the following could be the specificity?

a. Anti-JMH
b. Anti-Ch
c. Anti-Kn^a
d. Anti-Kp^a

Answer 28

b. Anti-Ch

Question 29

An antibody reacted with untreated RBCs and DTT treated RBCs but not with ficin-treated RBCs. Which of the following antibodies could explain this pattern of reactivity?

a. Anti-JMH
b. Anti-Yt^a
c. Anti-Kp^b
d. Anti-Ch

Answer 29

d. Anti-Ch

Question 30

The following antibodies are generally considered clinically insignificant because they have not been associated with causing increased destruction of RBCs, HDFN, or HTRs.

a. Anti-Do^a and anti-Co^a
b. Anti-Ge3 and anti-Wr^a
c. Anti-Ch and anti-Kn^a
d. Anti-Di^b and anti-Yt

Answer 30

c. Anti-Ch and anti-Kn^a