Test #4 Flashcards
Which lung has more lobes?
The right
Where does gas exchange take place?
Alveolar capillary membrane
What is ventilation?
The movement of air in and out of the respiratory system
What causes air to enter into the lungs?
Decreased intrathoracic pressure as the diaphragm increases the space in the lungs
What is respiration?
The process of gas exchange at the alveolar level and the diffusion of gases in the blood
What is the V/Q ratio?
Ventilation perfusion ratio
(Air flow to blood flow)
Normal is 4:5
What causes a low V/Q ratio?
Shunting where perfusion exceeds ventilation
The oxygen and carbon dioxide are there but they cannot be exchanged
What is perfusion?
Flow of blood to the capillaries
What is tidal volume?
The volume of air taken in and out with each breath
What is inspiratory reserve volume?
Additional air which can be inhaled after a normal inhalation
What is expiratory reserve volume?
The maximum volume of air that can be exhaled
What is vital capacity?
The maximum volume of air exhaled from a maximal inspiration
What is forced expiratory volume?
Volume exhaled forcefully over time in seconds
What is peak flow rate?
Maximal expiratory flow
What is a normal pH?
7.35-7.45
What is a normal PaCO2?
35-45
What is a normal HCO3?
22-26
What is a normal PaO2?
80-100
How fast can the respiratory system effect change for the pH?
15-30 minutes
How fast can the renal system effect change for the pH?
Hours to days
What are the signs of respiratory acidosis?
- Hypoventilation
- Hypoxia (results from hypoventilation)
- Decreased BP
- Dyspnea
- Headache
- Hyperkalemia
- Dysrhythmias due to increased K
- Drowsiness, dizziness, disorientation (neurological changes)
What are the signs of metabolic acidosis?
- Kussmaul’s to compensate (hyperventilation)
- Headache
- Decreased BP
- Hyperkalemia (watch for cardiac changes)
- Warm, flushed skin from vasodilation
- Nausea, vomiting, and diarrhea
- Changes in LOC
- Potential for seizures
What are some causes of alkalosis?
Hyperventilation from:
- Anxiety
- Pulmonary embolism
- High altitude
- Pregnancy
- Overuse of antacids
- Loss of gastric juices
- Potassium wasting diuretics
What are the signs of respiratory alkalosis?
- Seizures
- Rapid, deep breathing
- Hyperventilation
- Tachycardia
- Hypokalemia
- Numbness or tingling of extremities
- Lethargy and confusion
- Nausea, vomiting
What are the signs of metabolic alkalosis?
- Restlessness followed by lethargy
- Tachycardia
- Compensatory hypoventilation (bradypnea)
- Decreased LOC
- Tremors, muscle cramps, tingling, tetany
- Hypokalemia (watch for EKG changes)
Use of birth control pills increases change of what?
Blood clots and pulmonary embolisms
In alkalosis, the body dumps what to compensate for lack of hydrogen?
Body dumps potassium
What four processes result in metabolic acidosis?
- Overproduction of hydrogen ions (lactic acidosis, DKA)
- Under elimination of hydrogen ions (Kidney failure)
- Under production of bicarbonate (Kidney failure, impaired liver or pancreas)
- Over elimination/loss of bicarbonate (Vomiting and diarrhea)
What is the one underlying cause of respiratory acidosis?
What are some examples of causes (depress)?
Retention of CO2
D: Drugs, diseases of the neuromuscular system
E: Edema in the lungs
P: Pneumonia and excessive mucus production
R: Respiratory center of the brain is damaged
E: Emboli (can block branches of the lungs which means CO2 cannot get out and air cannot get in)
S: Spasm of bronchial tubes (asthma)
S: Sac elasticity (reduced in COPD)
What are the causes of respiratory alkalosis?
T: Temperature increase in body
A: Aspirin toxicity (causes body to hyperventilate)
C: Controlled mechanical ventilation
H: Hyperventilation
Y: Hysteria/anxiety
P: Pain, pregnancy
N: Neurological injury
E: Emboli
A: Asthma due to hyperventilation
What is the pathophysiology of respiratory alkalosis?
- Expelling too much CO2 due to tachypnea (hyperventilation)
- Kidneys excrete excess bicarbonate
What are the signs of respiratory alkalosis?
- Fast respiratory rate
- Neurological changes, tired
- Increased heart rate from working so hard
- Tetany, EKG changes, muscle cramps, positive chvostek’s sign
- Hypokalemia
What are the causes of metabolic acidosis (acidotic)?
A: Aspirin toxicity
C: Carbohydrates not metabolized
I: Insufficiency of kidneys
D: Diarrhea (body fluids are rich in bicarb), DKA
O: Ostomy drainage
T: Fistula
I: Intake of too much fat
C: Carbonic anhydrase inhibitors
What is the pathophysiology of metabolic alkalosis?
- Body has lost an excessive amount of hydrogen ions or body has increased bicarb production
- Lungs start trying to compensate and cause hypoventilation
What are the causes of metabolic alkalosis?
A: Excessive aldosterone (causes body to keep sodium which offloads hydrogen and potassium)
L: Loop diuretics (hydrochlorothiazide), causes you to pee of hydrogen ions
K: Alkali ingestion (baking soda, antacids, milk)
A: Anticoagulant (citrate), if you get a massive transfusion
L: Loss of fluids (severe vomiting, NG suction)
I: Increased bicarb administration
What is the pathophysiology of anemia?
Decreased red blood cell production (or increased destruction) leads to decreased oxygen delivery to the tissues
Which two things can cause decreased red blood cell production?
1) Bone marrow deficiency (aplastic anemia, cancer)
2) Nutritional deficiency: iron, folate, B12, copper, chronic blood loss
What are the symptoms of decreased red blood cell production?
Pallor, tachycardia, headache, fatigue, shortness of breath, weakness, murmur
What are the symptoms of anemia from blood loss?
Pallor, fatigue, headache, weakness, cool skin, tachycardia, decreased peripheral pulses, low blood pressure
What are the symptoms of anemia from increased red blood cell destruction?
Yellow sclera, pallor, fatigue, headache, dark urine, splenomegaly, hepatomegaly
What is the most common type of anemia in children and how is it usually treated?
Iron-deficiency
Usually from excessive intake of cow’s milk and low iron
Vitamin C needed to absorb iron
What are the clinical features of sickle-cell anemia?
- Obstruction caused by sickled red blood cells (causes local hypoxia)
- Vascular inflammation
- Increased red blood cell destruction
What medication can we give for sickle cell anemia?
Hydroxyurea: causes red blood cells to be bigger and rounder
L-glutamate therapy increases the amount of free glutamate to reduce oxidative stress
What are some nursing considerations for patients with sickle cell anemia?
- Preventative antibiotics
- Avoid contact sports
- Give pain medications
- Promote rest
- Do not use ice
- Avoid aspirin
- Avoid skin puncture
What is the pertinent family education for patients with sickle cell anemia?
- Seek early intervention
- Recognize signs of stroke!
These children are prone to clotting
What is the first organ affected in a vaso-occlusive crisis?
Spleen
What will labs look like in iron deficiency anemia?
Low red blood cells, hematocrit, and hemoglobin
What is the physical presentation of sickle cell anemia?
Pain, shortness of breath, fatigue, pallor, jaundice (due to RBC breakdown)
What will labs look like in sickle cell anemia?
Decreased hemoglobin, increased white blood cells, elevated bilirubin
What are the characteristics of beta thalassemia?
Inherited genetic disorder which causes defective synthesis of hemoglobin, structural impairment of red blood cells, shorted red blood cell lifespan
What are the symptoms of beta thalassemia?
Pallor, fatigue, heart failure, cardiomegaly, hepatomegaly
How is beta thalassemia treated?
Blood transfusion
Stem cell transplant
Bone marrow transplant
What is aplastic anemia?
When all components of the bone marrow are suppressed (RBC, WBC, platelets)
Can be primary or accquired
How is primary aplastic anemia treated?
Bone marrow suppression, transplantation
What are the symptoms of aplastic anemia?
Infection, fatigue, fever, tachycardia, petechiae, purpura, bloody stools, weakness, neutropenia can lead to infection
What neutrophil count qualifies for neutropenia?
Less than 1500
What is hemophelia?
An X linked inherited bleeding disorder that impairs clotting
Hemophilia A: Factor 8 (VIII)
Hemophilia B: Factor 9 (IX)
Female carriers have what chance of passing hemophilia to son’s?
50%
What percentage of cases are caused by a new mutation?
30%
What are the clinical manifestations of hemophilia?
Hemarthrosis, bleeding
What are the treatments for hemophilia?
- Replace missing clotting factor
- Control bleeding
- Desmopressin shown to increase factor 8 (A)
- Gene therapy
What are the nursing considerations for patients with hemophelia?
- Limit invasive procedures
- Limit joint involvement
- Avoid aspirin
- Avoid IM injections, rectal temps, contact sports
What medication prevents transmission of HIV from mother to child?
HAART
How is severe combined immunodeficiency treated?
- Prevent infection
- Donor bone marrow, IVIG, prophylaxis
What are the chracteristics of Wiskott-Aldrich syndrome?
- Thrombocytopenia (platelets less than 150,000)
- Eczema
- Immunodeficiency of B and T cells
- X linked recessive inheritance
What labs are consistent with hemophilia?
APTT, PT, Platelets
- APTT levels prolonged (normal: 30-40 seconds)
- PT normal (11-13 seconds)
- Platelets normal (150,000-450,000)
What are the characteristics of COPD?
A progressive condition which blocks air getting into the lungs and CO2 getting out
Either chronic bronchitis or emphysema
What are the characteristics of chronic bronchitis?
Chronic infection which is accompanied by mucus buildup impairs gas exchange
What is emphysema?
Lung damage caused by weakening or breaking of the alveoli
What is COPD usually caused by?
Long term exposure to irritants
What are the symptoms of COPD?
- Easily fatigued
- Frequent respiratory infections
- Use of accessory muscles
- Orthopnea
- Cord pulmonale (right sided heart failure)
- Wheezing
- Pursed lip breathing
- Chronic cough
- Barrel chest
- Prolonged expiratory time
- Digital clubbing
How is COPD treated?
- Smoking cessation
- Short-acting bronchodilators (albuterol)
- Long-acting bronchodilators (salmeterol)
- Inhaled steroids (budesonide, fluticasone)
What percentage of COPD exacerbations are viral and what percentage are bacterial?
50% viral, 50% bacterial
What are some non-infectious causes of a COPD exacerbation?
Allergies, smoking, pollution, stress, nonadherance
What is pneumonia?
Infection in the alveoli which causes inflammation and leakage of fluid into the air sacs
What does the fluid inside the air sacs do?
Blocks gas exchange
What are the symptoms of pneumonia?
Dyspnea, wet cough, fever, chest pain secondary to inflammation, clammy or blue skin, low BP, nausea, vomiting, hemoptysis
What is a pulmonary embolism?
A blood clot in the lungs
How is a PE diagnosed?
Elevated d-dimer, chest x ray, VQ scan
How do we treat a PE?
Anticoagulants and thrombolytics (streptokinase, alteplase)
What is the standard course of heparin therapy for a PE?
5-10 days
Where do you want the PTT for a patient on heparin?
1.5 - 2.5 x the patients control