Test 3: Pharmacokinetics & Misc Principles of INH Agents Flashcards
All methyl ethyl ethers undergo ____ metabolism.
Oxidative.
-Dependent on P450 system, genetic factors and chemical structure of the agent
Which is the only agent to undergo reductive metabolism?
Halothane
What is the principle objective of inhaled anesthesia?
To achieve a constant and optimal partial pressure of the agent.
-A series of partial pressure gradients propel INH agent across various barriers.
What is the volume in the Bag?
3 Liters
What is the volume in the CO2 Absorbent?
2 Liters
What is the volume in the Circuit?
2 Liters
What is PD?
Pressure delivered
-Coming out of vaporizer
What is PI?
Pressure inspired.
-Moves through dead space of circuit and into patient.
What is PA?
Pressure in the Alveoli
What is Pa?
Pressure as the gas enters arterial blood
What is Pbr?
Pressure in the brain.
-Can’t be measured, so we measure Et of the agent instead to determine the amount of agent present in the brain.
What is the total volume of dead space in the circuit (bag + CO2 absorbent + circuit volume)?
7 Liters
Goal: _____ Pressure to equal ______ Pressure. (Blue Box!)
Goal: Inspired Pressure (PI) to equal Alveolar Pressure (PA).
What contributes to the input to the alveoli?
-Anesthesia machine
-Inspired Partial Pressure (PI)
-Alveolar Ventilation (coming from the body or mechanical ventilation)
What is uptake?
Gas travels from the alveoli into the blood.
-Alveoli is the exchange zone.
-Gas crosses capillary beds
-Going down the gradient
-Effected by solubility of the agent, cardiac output, and the alveolar to venous partial pressure gradient.