Test 3/Gallbladder Flashcards
Gallbladder and Exocrine Pancreas
*Bile is secreted by the liver and stored in the gallbladder
Liver excretes-
Approximately 500 to 1000 mL/day. Most (95%) of the bile that has entered the intestines is reabsorbed in the last part of the small intestine (terminal ileum), and returned to the liver for reuse
Composition of bile
- Water
- Conjugated billirubin
- Organic and inorganic ions
- Small amount of proteins
- 3 lipids (bile salts, lecithin, & cholesterol
- These three must remain intact and balanced or the cholesterol will precipitate and form cholesterol gall stones*
Gallbladder has a capacity of
50 ml. It concentrates the bile 10 fold by removing water and stores it until a person eats
Cholecystokinin stimulates:
the digestion of fat and protein
Cholelithiasis
Stone formation in the gallbladder
Cholecystitis
Acute or chronic inflammation
Choledochrolithiasis
Stones form and migrate to the common bile duct
Risk Factors for Cholelithiasis:
- Obesity
- Middle Age
- Pregnancy and use of oral contraceptives
- Rapid weight loss- 5 lbs a week
- Disease of Ileum
- Gender-twice as common in women
Choledochrolithiasis stones form and-
migrate to the common bile duct
Clinical manisfestations of choledochrolithiasis:
- Indigestion to severe pain
- Fever
- Nausea/vomiting
- diaphoresis
- Murphy’s sign- plapation of RUQ causes pain which causes temporary inspiratory arrest
- Depends on if stones are mobile dark urine, jaundice if hepatic ducts involved
Complications of choledochrolithiasis:
- Gangrenous cholecystitis
- Subphrenic abscess
- Pancreatitis
- Gall bladder rupture: peritonitis
Acute Cholecystitis
- Localized or diffuse RUQ pain.
- Radiation to right scapula. Vomiting/Constipation
- Low grade fever
Radiation of abdominal pain:
- Perforated Ulcer
- Biliary Colic
- Renal Colic
- Dysmenorrhea/Labor
- Renal Colic (Groin)
Diagnostics for Cholecystitis:
- Ultrasonography
- Cholecystography
- Cholangiogram
- ERCP
- Percutaneous transhepatic cholangiography
- WBC/CBC
- Direct and indirect Bilirubin
- ALT/AST
Endoscopic Retrograde Cholangiopancreatography (ERCP)
A stent is protruding from the bile duct into the wall of the small intestine. The stent bypasses the leak and allow the bile duct to heal without the need for major surgery
Cholecystography
- 6 tablets (1 at a time) are swallowed that contain the contrast medium
- Contrast media (dye) is injected in the cystic duct
Liver Profile test includes:
- ALT
- AST
- Alkaline Phosphatase
- GGTP
- Bilirubin
- Prothrombin time
- Protein
- LDL
- Albumin
- Globulin
Conservative Therapy:
- Fluid/electrolyte balance, pain control, NG if severe, ATB’s if indicated
- Endoscopy to place stents, remove stones
- Oral dissolution therapy with ursodeoxycholic acid (Actigal)
- Extracorporeal shock wave lithotripsy
Surgery:
- Lap. cholecystectomy
- Open cholecystectomy with a T tube
- Transhepatic biliary catheter
Extracorporeal Shock Wave Lithotripsy
Monitor—-Ultrasound transducer——Shock stone in gallbladder
- **There is an underwater spark discharge and ellipsoidal reflector
- Pt laying in a water bath
Laparoscopic Cholesystectomy involves
Laparoscopic instruments, Gallbladder and Camera
Medication
- Analgesics
- Anticholinergics: Robinal for spasm
- Fat soluble vitamins for chronic gallbladder disease
- Bile salts for chronic gallbladder disease
- Pruritus: Questran, moisturizers
Nutrition:
- Low fat diet
* Reduced calorie if obese