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Neuropharmacology > test 3 > Flashcards

test 3 Flashcards

1
Q

Alpha 1 Receptors (NE, EPI)

A

Alpha 1A, Alpha 1B, and Alpha 1D

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2
Q

Alpha 1A, Alpha 1B, and Alpha 1D NON-SELECTIVE AGONIST

NE, EPI

A

-DA, NE, Epinephrine, Phenylephrine, Ephederine, Pseudoephedrine

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3
Q

Alpha 1A
SELECTIVE AGONIST
(NE, EPI)

A

TETRAHYDRAZOLINE

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4
Q

Alpha 1A, Alpha 1B, and Alpha 1D NON-SELECTIVE ANTAGONIST

NE, EPI

A
  • Phentolamine

- Prazosin

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5
Q

Alpha 1A, Alpha 1B, and Alpha 1D SUICIDE ANTAGONIST

NE, EPI

A

Phenoxybenzamine

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6
Q

Alpha-1: Gq – excitatory

NE, EPI

A

Activate PLC –> Increases PKC activity–> Increases cAMK-2

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7
Q

Alpha-2: Gi -Inhibitory

A

Decreases PKA activity

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8
Q

Alpha 2A, Alpha 2B, and Alpha 2C NON-SELECTIVE AGONIST

NE, EPI

A

NE, Epinephrine, and Clonidine

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9
Q

Alpha 2A
PARTIAL AGONIST
(NE, EPI)

A

-LSD-25

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10
Q

Alpha 2A, Alpha 2B, and Alpha 2C NON-SELECTIVE ANTAGONIST

NE, EPI

A

PHENTOLAMINE, PRAZOSIN, YOHIMBINE

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11
Q

ALPHA 2 RECEPTOR

G-protein Alpha subunit

A

-Gi

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12
Q

ALPHA 2 RECEPTOR

Beta/gama subunit

A
  • Inhibit –> VDCCs

- Activate–>CDKCs

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13
Q

Beta receptors are

A

Beta1, Beta2, and Beta3

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14
Q

Beta1, Beta2, and Beta3

Non-Selective Agonists

A

NE, Epinephrine, Isoproterenol, ephedrine, clenbuterol

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15
Q

Beta2

Selective Agonists

A
  • Albuterol

- Salmeterol

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16
Q

Beta1, Beta2, and Beta3

Non- Selective Antagonists

A

PROPRANOLOL

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17
Q

Beta1, Beta2, and Beta3

Selective Antagonists

A

Atenolol

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18
Q

Beta1, Beta2, and Beta3 G-protein

A

Gs

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19
Q

5-HT1 receptors

A

5-HT 1A, 5-HT 1B, 5-HT 1D

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20
Q

5-HT 1A, 5-HT 1B, 5-HT 1D

NON-SELECTIVE AGONIST

A

5-HT and QUIPAZINE

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21
Q

5-HT 1A

Selective agonist

A

BUSPIRONE

22
Q

5-HT 1B, 5-HT 1D

Selective Agonist

A
  • ERGOTAMINE

- SUMATRIPTAN

23
Q

5-HT 1A, 5-HT 1B, 5-HT 1D

SELECTIVE ANTAGONIST

A

PINDOLOL

24
Q

5-HT 1A, 5-HT 1B, 5-HT 1D

G-Protein

A

Gi

25
Q

5-HT 2 RECEPTORS

A

5-HT 2A, 5-HT 2B, 5-HT 2C

26
Q

5-HT 2A, 5-HT 2B, 5-HT 2C

NON-SELECTIVE AGONIST

A

5-HT

QUIPAZINE

27
Q

5-HT 2A

PARTIAL AGONIST

A

LSD-25

PSILOCYBIN/PSILOCIN

28
Q

5-HT 2A_______, 5-HT 2C____

SELECTIVE AGONIST

A
  • DMT

- AGOMELATINE

29
Q

5-HT 2A

SELECTIVE ANTAGONIST

A

-ketanserin

30
Q

5-HT 2B

SELECTIVE ANTAGONIST

A

METERGOLINE

31
Q

5-HT 2C

SELECTIVE ANTAGONIST

A

RITANSERIN

32
Q

5-HT 2A, 5-HT 2B, 5-HT 2C

NON-SELECTIVE ANTAGONIST

A
  • Mesulergine

- Dibenzyline

33
Q

5-HT 2A, 5-HT 2B, 5-HT 2C

G-protein

A

Gq

34
Q

5-HT3 RECEPTORS

A

5-HT 3A

5-HT 3B

35
Q

5-HT 3A and 5-HT 3B

Non-Selective agonist

A

5-HT

QUIPAZINE

36
Q

5-HT 3A and 5-HT 3B

Selective agonist

A

CBG

37
Q

5-HT 3A and 5-HT 3B

Selective antagonist

A

Ondansetron

38
Q

5-HT 3A and 5-HT 3B

Mechanism

A

Mostly a sodium cation channel

39
Q

5-HT RECEPTOR

A

5-HT4, 5-HT6, and 5-HT7

40
Q

5-HT4, 5-HT6, and 5-HT7

NON-SELESCTIVE AGONIST

A

5-HT

QUIPAZINE

41
Q

5-HT 6 and 5-HT 7

NON SELECTIVE ANTAGONIST

A

CLOZAPINE

42
Q

5-HT4, 5-HT6, and 5-HT7

G-Protein

A

Gs

43
Q

Histamine (HA) Receptors

A

H1, H2, H3, H4

44
Q

H1 G-Protein (Post syn)

A

Gq

-Mast cells

45
Q

H2 G-Protein (Post Syn)

A

Gs

-Parietal cells

46
Q

H3_____ and H4 G-Protein

Both pre and Post

A

Gi
H3: Is an Autoreceptor
-H4: Tissue (Bone marrow, neutrophils, basophils)

47
Q

Histamine (HA) agonist for H1-H4

A

Histamine

48
Q

Histamine (HA) agonist for H2

A

Dimaprite

49
Q

Histamine (HA) agonist for H3 &H4

A

Imetit

50
Q

Histamine (HA) Antagonist for H2

A

CIMETIDINE

51
Q

Histamine (HA) Antagonist for H3

A

CLOBENPROPIT **

PHENOPROPIT

Neuropharmacology (1 decks)

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