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Immunology Spring 2021 > Test 2 > Flashcards

Test 2 Flashcards

1
Q

RBC transfusions

A

Type 2

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2
Q

Hemolytic Disease of Newborn

A

Type 2

prevent with anti-RhD commercial IgG Rhogam shot

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3
Q

idiopathic hemolytic anemia

A

Type 2

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4
Q

Thrombocytopenia

A

Type 2

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5
Q

Cole agglutinin disease

A

IgM aggregates, Type 2

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6
Q

Warm Agglutinins Disease

A

IgG aggregates (internal body temp)

Type 2

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7
Q

drug induced hemolytic anemia

A

type 2

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8
Q

pernicious anemia

A

type 2

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9
Q

good pastures syndrome

A

type 2
antibody against GBM (glomerular basement membrane) followed by recruitment of PMNs, and NET which damages
tissues

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10
Q

pancreatitis

A

antibody against islet cells

type 2

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11
Q

rheumatic fever

A

strep antibody against heart

type 2

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12
Q

thyroiditis

A

type 2

antibody against thyroglobulin

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13
Q

pemphigoid

A

type 2

skin basement membrane

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14
Q

primary biliary cirrhosis

A

type 2

mitochondria ; not disease causing

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15
Q

Sjorgen Syndrome

A

type 2

salivary glands

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16
Q

myasthenia gravis

A

acetylcholine receptor

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17
Q

graves’ disease

A

hyperthyroidism, acts like TSH

type 2

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18
Q

cryoglobulin vasculitis, raynauds

A

type 3

IgM aggregates

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19
Q

hypersensitive allergic pneumonitis

A

type 3
starts of as th2 disease
can turn into type 4 granuloma bc organisms have intracellular phase,

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20
Q

lupus

A

type 3

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21
Q

CIC mediated glomerulonephritus

A

type 3
cic non-specifically deposits on GBM of kidney

different than good pasteurs syndrome

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22
Q

farmers lung

A

can be type 3

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23
Q

rheumatoid arthritis

A

type 3

IgM against IgG

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24
Q

chronic hepatitis

A

type 3

persistent viral antigen( liver damage impedes CIC clearance)

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25
Q

alcoholic cirrhosis

A

liver damage and impedes cic clearance

type 3

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26
Q

serum sickness

A

type 3

27
Q

anaphylaxis

A

can be type 1 or 3

occurs when sensitized individual is re-exposed to antigen

if the individual is atopic, type 1 reaction …antigen has direct access to circulation causing IgE and histamine release)

type 3 competent causes histamine r lease

28
Q

major players in type 2 and type 3

A 
c3b 
c3a
c5a
PMNs
lysis
29
Q

skin testing

A

type 4

details if individual precious encountered antigen or

immune competency of suppressed people

30
Q

causes of granulomas

A

can be infections (tb, mumps, leprosy)

or non infections (wood, glass, metals, dust)

31
Q

irritant contact dermatitis

allergic contact dermatitis

A

type 4

differentiate by T cell involvement/activation (only in allergic) via elispot assay or patch test

32
Q

scratch test

patch test

A

scratch used for type 1 (minutes)

patch used for type 2 (days)

33
Q

why no antibody response in type 4 allergic contact dermatitis

A

no free antigen

it’s a chemical, cause hapten formation but no free antigen for sIg to bind

34
Q

well demarcated lesions

A

type 4

35
Q

t/f little to no mast cell activation in type IV acute contact dermatitis

A

true
also not much complement

histamine release from complement binding mast cell in type 3 and 2 though

treat by removing offending agent or topical anti inflammatory

36
Q 
type IV
a
b
c
d
A

a: th1 cells recruit and activate macrophages…contact dermatitis
b: eosiniphils cause asthma
c: cd8 can cause contact contact dermatitis by hapten on MHC1
d: neutrophils , Behcet disease

37
Q

formaldehyde

A

type 4

38
Q

nickel

A

type 4

39
Q

how can you inherit allergies

A

leaky gap junctions, genes

mhc haplotype

parents have allergies

40
Q

non inherited characteristics of allergies

A

class switch from igg to ige , using il4 and il13 cytokines

b cell with il4 and il13 receptors

iga deficiency (allows allergens to bypass mucusol surfaces)

presence and reactivity of Tregs (release il10 which prevents class switch)

environment

41
Q

anaphylaxis

A

constriction of bronchial tubes , sometimes rash and fever , life threatening

caused by histamine release from mast cells

either by IgE binding (1) or C3a and C5a binding (3)

42
Q

wheal and flare

A 
type 1 
type 3 (from histamine release from mast cells via complement)
43
Q

allergic rhinitis

A

inflammation of the eye nose or throat

44
Q

c3 convertase

A

C3bBbP

C1C2bC4b

45
Q

mutations in C1 inhibitor can cause

A

vasodilation bc too much C3a and C5a

46
Q

pleiotropic cytokine

A

IL4

class switch
macrophage inhibitor
t cell growth factor

47
Q

redundant cytokines

A

il4
il5
il2

b cell proliferation

48
Q

antagonistic cytokines

A 
Il10 and IL4 
perfect class switch

IFNy and Il10 macrophage activator and inhibitor

49
Q

autocrine cytokines

A

il2

50
Q

endocrine cytokine

A

IL1

51
Q

paracrine cytokine

A

IL 4 from t cell causes adjacent b cell to class switch

52
Q

how many types of cytokine receptor families

A

i
i
iii
iv

53
Q

type and type ii property

A

have separating binding and signaling domain

54
Q

IL2 low intermediate and high

A

a
by
aby

55
Q

anakinra

A

receptor agonist

56
Q

entanercept and infliximab

A

tnf soluble receptor

57
Q

clinical uses of GM-CSF

A

bone marrow transplant

cytopenias

58
Q

EPO

A

kidney dialysis

anemia from chemo

59
Q

cytokines clinically used for cancer

A

ifn-a

60
Q

cytokines clinically used to viral therapy like hep b and c

A

if a

61
Q

integrins function

A

cell cell

cell ecm interactions

62
Q

chemokines act via what receptor

A

g coupled protein

63
Q

chemokines jobs

A

chemotaxis
degranulation
angiogenesis

Immunology Spring 2021 (1 decks)

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