Test 1 Pk/Pd/Induction agents

Question 1

benzos metabolisms primary in liver by these two forms of metabolism

Answer 1

• microsomal oxidation (susceptible to age and disease)
• glucoronide conjugation

Question 2

active metabolites of diazepam

Answer 2

• desmethyldiazepam
• oxazepam

Question 3

metabolism of Barbiturates

oxy (metho) and thiobarb (thiop)

Answer 3

metabolized to inactive thru hepatic oxidation

Question 4

ketamine: primary site of anelgesic site

Answer 4

thalamoneocortical system

Question 5

preservative for generic vs brand name propofol

Answer 5

• diprivan - EDTA
• generic - sodium metabisulfite

Question 6

forpropofol metabolized to propofol by this enzyme

Answer 6

alkaline phosphatase

Question 7

genital and anal burning (induction agent)

Answer 7

fospropofol

Question 8

pKa of Ketamine

Answer 8

7.5

Question 9

active metabolite of barbs after high dose only

Answer 9

pentobarbital

Question 10

drugs that induce ALA synthase (4 from APEX)

Answer 10

• barbs
• etomidate
• glucocorticoids
• hyddralyzine

Question 11

precedex pKa

Answer 11

7.1

Question 13

active metabolite of midazolam

Answer 13

1-hydroxymidazolam

(short lived and conjugated rapidly to inactive unless renal failiure slows it down)

Question 14

absorption from gut depends on these (4)

(NH workbook)

Answer 14

• GI motility
• GI pH
• particle Size
• physicochemical interaction w/ gut contents

Question 15

drugs w/ protein binding > 90% that have unexpected intensification if displaced

Answer 15

• warfarin
• phenytoin
• propranolol
• propofol
• fentanyl (and its analogues)
• diazepam