Test 1 Flashcards
Why is it optimal for a patient to have an empty stomach prior to surgery?
Decreases likelihood of aspiration pneumonia
Conditions that elevate intra abdominal pressure and therefore increase aspiration risk
Morbid obesity
Pregnancy
Conditions that delay gastric emptying and therefore increase aspiration risk
Gastroparesis
Pregnancy
Abdominal trauma
Minimum fasting period for clear liquids
2 hours
Minimum fasting period for breast milk
4 hours
Minimum fasting period for infant formula
4 hours for < 3 months
6 hours for > 3 months
Minimum fasting period for nonhuman milk
6 hours
Minimum fasting period for light meal
6 hours
Why does a patient need a preoperative bowel prep?
Decreases abdominal contamination in the event of bowel entry
Emergency surgery pre-op questions
AMPLE
Allergies
Medications - when did you most recently take them
Past medical and surgical history
Last meal
Events that immediately preceded this surgery
Total body water is distributed with about _____ existing intracellularly and _____ found in extracellular spaces
2/3 intracellular
1/3 extracellular
The extracellular portion of body water is _____ interstitial and _____ intravascular
3/4 interstitial
1/4 intravascular
Plasma volume is _____ or about _____% of TBW
1/12
8.3
Total kg (body weight) x _____ = total body water
0.6
Fluid maintenance requirement for first 0-10 kg of body weight
100 ml/kg/d
Fluid maintenance requirement for next 10 mg of body weight
50 ml/kg/d
Fluid maintenance requirement for all subsequent kg of body weight
20 ml/kg/d
Electrolyte requirements for maintenance of sodium
1-2 mEq/kg/d
Electrolyte requirements for maintenance of potassium
0.5-1 mEq/kg/d
Signs of fluid shifts out of intravascular space
Changes in vitals: blood pressure, heart rate, central venous pressure
Decreased urine output
Volume excess signs
Weight gain, pulmonary edema, peripheral edema, S3 gallop
When does third-spaced fluid tend to mobilize after surgery?
POD #3
Fever associated cytokines are _____, ______, ______, and ______
IL-1
IL-6
TNF-alpha
IFN-gamma
Differential diagnosis of a postop fever
Wind (atelectasis, pneumonia) Water (UTI) Wound (wound infection, abscess) Walking (DVT, PE) Wonder drug or what did we do?
Most common onset of atelectasis or pneumonia
Atelectasis POD #1
Pneumonia POD #1-3
Most common onset of UTI
POD #3
Most common onset of wound infection or abscess
POD #5
Most common onset of DVT or PE
POD #7
Risk factors for post-op UTI
Female gender
Older age
Diabetes
Immobilization
Virchow’s Triad
Stasis
Vascular damage
Hypercoagulability
Treatment for malignant hyperthermia
Resuscitation, rapid cooling, IV dantrolene
New onset abdominal pain, abdominal distention, peritoneal signs post surgery
Anastomotic leak
Fever, tachycardia, hypotension post surgery with abdominal signs
Anastomotic leak
Raise threshold for CNS toxicity of local anesthetics
Benzodiazepines
ADRs of sedation, disorientation
Benzodiazepines
Tolerance observed in patients with chronic use of alcohol
Barbiturates
ADRs of cardiac and respiratory depression (monitoring important)
Barbiturates
Avoid in porphyria
Barbiturates
Potent ultra-short acting hypnotic without analgesic properties
Etomidate
Works on GABA receptors
Etomidate
Propofol
Must follow with analgesic and muscle relaxant drugs
Etomidate
ADRs of hypotension, cardiac dioxide retention, suppresses corticosteroid synthesis at adrenal cortex
Etomidate
ADRs of respiratory depression, N/V, constipation
Opioids
Associated with unconsciousness, analgesia, and amnesia; ER use with orthopedic indications and children
Ketamine
Allows fractures to be reduced in a safe and effective method
Ketamine
ADRS of hallucinations, bad dreams, increased muscle tone/rigidity
Ketamine
Lipophilic, cannot see through this IV anesthetics
Propofol
Used often in neuro ICU, it’s rapid onset in less than a minute and it’s lasting effects of < 15 minutes makes it widely used and hugely effected
Propofol
ADRs of significant respiratory depression, hypotension, injection site pain
Propofol
Agents include nitrous oxide, sevoflurane, isoflurane, desflurane
Inhaled anesthetics
ADRs include N/V, malignant hyperthermia, caution in patients with renal/hepatic dysfunction
Inhaled anesthetics
Includes lidocaine, bupivacaine, prilocaine, dibucaine
Amino amides
Use for bupivacaine
Used in epidurals
Use for dibucaine
Suppository use for pain relief from hemorrhoids
Includes benzocaine, cocaine, procaine, and tetracaine
Amino esters
Concentration, max dose, onset, and duration of lidocaine
1-2%
4.5-5 mg/kg
< 2 min
0.5-1 hour
Concentration, max dose, onset, and duration of lidocaine with epinephrine
1-2%
7 mg/kg
< 2 min
4-6 hours
Concentration, max dose, onset, and duration of bupivacaine
0.25%
2.5 mg/kg
5 min
2-4 hours
Concentration, max dose, onset, and duration of bupivacaine with epinephrine
0.25%
max 225 mg
5 min
3-7 hours
Concentration, max dose, onset, and duration of procaine
0.25-0.5%
350-600mg
2-5 min
0.25-1 hour
Primary site of action is spinal nerve roots
Epidural anesthesia
ADRs of spinal anesthesia
Hematoma, headache, infection
Risk factors that affect pain control in perioperative settings
Preoperative pain (higher baseline), anxiety, genetics, female gender, opioid tolerance
Alpha2-receptor agonist in areas of brain
Dexmedetomidine
Used in ICU setting for sedation and in anesthesia for brief procedures
Dexmedetomidine
ADRs: monitor HR, blood pressure, sedative effects
Dexmedetomidine
Risk factors for PONV
Female gender Motion sickness/previous PONV Non-smoking status Post-operative use of opioids Use of inhaled anesthetics
Recommended anxiolytic for PONV reduction
Benzodiazepines
Pharmacologic Treatment options for PONV
Serotonin antagonists (ondansetron, granisetron) Neurokinin inhibitors (aprepitant) Steroids (dexamethasone) Butyrophenones (Droperidol) Benzodiazepines
ADRs of HA, diarrhea, constipation, arrhythmia
Serotonin Antagonists
Ondansetron, Granisetron
ADRs of HA, diarrhea, weakness, dizziness
Neurokinin inhibitors
Aprepitant
ADRs of dizziness, mood change, nervousness
Steroids
Dexamethasone
ADRs of sedation, confusion, dry mouth, urinary retention
Antihistamines
ADRs of prolonged QT interval (black box warning), hypotension, tachycardia, extrapyramidal symptoms
Butyrophenones
Droperidol
Four crucial assessment for burn evaluations
- airway management
- evaluation of other injuries
- estimation of burn size (burn depth and %TSA)
- diagnosis of CO and cyanide poisoning
Parkland formula for burns
LR 4cc x kg x %BSA
Half over the first 8 hours, half over the next 16 hours
Potential complications of electrical burns
Cardiac arrhythmias
Compartment syndrome
Rhabdomyolysis
Treatment for smoke inhalation
Fluids and supportive care
Oxygen
Possible intubation
Bronchodilators (albuterol)
Signs/symptoms of carbon monoxide poisoning
Headache, lightheadedness, dizziness, confusion, tachypnea, hypoxia
ASA Risk of normal, healthy patient
0.1%
ASA Risk of mild systemic disease
0.2%
ASA Risk of severe systemic disease
1.8%
ASA Risk of severe systemic disease that is a constant threat to life
7.8%
ASA Risk of moribund patient, not expected to survive without an operation
9.4%
Risk factors for post op pneumonia
Upper abdominal or cardiothoracic procedures Prolonged anesthesia (> 4 hrs) Age > 60 Tobacco abuse (> 20 p/y) COPD/HF/OSA/Pre-op sepsis Hypoalbuminemia Impaired cognition
___% mortality if hemodialysis is required
50
How many calories does a surgical patient need?
30 kcal per kg per day
Protein and nonprotein calories for wound healing
1 gram protein/kg/day
150 nonprotein calories per 6.25 gm of protein
Phase of wound healing that begins immediately and lasts for the first few days
Hemostasis and inflammation
Phase of wound healing that starts after the first few days and lasts for several weeks
Proliferation
Phase of wound healing that begins after 2-3 weeks and lasts several months
Maturation
Phase of wound healing with platelet activation and release of cytokines. Initial cells are platelets quickly followed by neutrophils and macrophages
Inflammatory Phase
Fibroblasts are the principal cell involved. These cells are activated by the many cytokines released by WBCs. Initially type III collagen is laid down and over time this is replaced by type I collagen. Endothelial cells, leading to new blood vessels (granulation tissue). New skin is formed.
Proliferation Phase
During this phase, there is maturation of the wound collagen with collagen breakdown. Scar remodeling continues for up to 12 months
Maturation Phase
A wound will eventually reach about ____% of its original strength
80
Superficial infections make up ___% of all surgical site infections, while deep infections make up ___%
75%
25%
Causes of necrotizing fasciitis
Group A strep, staph aureus, clostridium perfringens, bacteroides fragilis and aeromonas hydrophila
Administered pre-anesthesia reduces PONV for up to 48 hours after surgery
Neurokinin Inhibitors
Aprepitant