Test 1 Flashcards
MCV
What it measures?
Mean Corpuscular Volume
Measure of the average volume, or size of a single RBC
What is MCV used to Classify?
Anemias
Microcytic
Abnormally small
Examples of microcytic
Iron deficiency, Thalassemia
Macrocytic
Examples
Abnormally Large
Vitamin B12 of Folic Acid deficiency
MCH
What it measures
Mean Corpuscular hemoglobin concentration
measure of the average concentration of hemoglobin within a single RBC
Hypochromic
Examples
Decreased MCHC
Iron deficiency, anemia, thalassemia
Normochromic
Examples
Normal MCHC
hemolytic anemias
Alteration is shape may cause MCHC levels _______ normal
examples
ABOVE
Transfusion reactions, erythroblastosis fetalis
RDW
Measures?
Red Blood Cell Distribution Width
Measures variation in RBC size
WBC
Define
Total number of WBC (leukocytes) in 1mm 3 of peripheral venous blood and the measure of each type of leukocyte
Increase in WBC
Leukocytosis
Examples of Leukocytosis
Infection, leukemic neoplasia, other malignancy, trauma, stress, hemorrhage, tissue necrosis, inflammation, dehydration, thryroid storm, steroid use
Decrease in WBC
Leukopenia
Examples of Leukopenia
Drug Toxicity, Bone marrow failure, overwhelming infections, dietary deficiency, congenital marrow aplasia, bone marrow infiltration, autoimmune disease, hyperplenism
Increased Neutrophils
Neutrophilia
Neutrophilia
Causes
Acute bacterial infections and trauma
Immature Neutrophils
Band or Stab cells
Causes of Band Cell
may indicate an acute ongoing infection
Decreased Neutrophils
Neutropenia
Causes of Neutropenia
in aplastic anemia, dietary deficiency, overwhelming bacterial infection, viral infections, radiation therapy
INCREASED LYMPHOCYTES
Lymphocytosis
Lymphocytosis in……
Chronic bacterial infections and Acute Viral infections
Decreased lymphocytes
lymphocytopenia
Lymphocytopenia in
leukemia, Sepsis, Immunodeficiency diseases, lupus, late HIV, Drug therapy, radiation therapy
Monocytes -
Remove necrotic debris and microorganism from the blood
Increased Monocytes
Found in….
Monocytosis
Chronic Inflammatory Disorders
Increased in Viral infections and parasitic infections
Decreased Monocytes
Found in…..
Monocytopenia
Prednisone drug therapy
Eosinophils increased
Found in….
Eosinophilia
Allergic and parasitic reactions, Eczema, Leukemia, Autoimmune diseases
Decreased Eosinophils
found in…..
Eosinopenia
increased adrenosteroid production
Basophils (mast cells) - Increased?
Found in
Basophilia
In allergic reactions and parasitic infections
Basophils contain….
Infiltrate the tissue involved and further the _______ _________.
heparin, histamine, and serotonin
Inflammatory Reaction
Decreased Basophils?
Caused by
Basopenia
Stress Reactions
Blood Smears Provides
significant amount of information concerning drugs and diseases that affect RBCs and WBCs
Blood Smears - Special Stains can be applied to detect???
Infections, infestation, leukemia and other diseases
Platelet Count
Actual number of platelets per cubic mm of blood
Increased Platelet
Thrombosytosis
Thrombocytosis found in
Malignant disorders, Polycythemia vera, Postsplenectomy syndrome, Rheumatoid arthritis, Iron deficiency anemia
Decrease in Platelet Count
Thrombocytopenia
Thrombocytopenia found in
Hyperplenism, Hemorrhage, Leukemia, Grave’s Disease, Cancer Chemotherapy, Infection, Lupus
Increase greater than 1 million of Platelet Count
Thrombocythemia
ESR
Erythrocyte Sedimentation Rate
ESR measure
Measurement of the rate at which RBCs settle in saline solution or plasma over a specified time period
Examples of ESR
Chronic Real Failure, Malignant Diseases, Necrotic Diseases, Severe Anemia
Falsely Decreased Levels
Sickle Cell Anemia, Spherocytosis, Hypofibrinogenemia, Polycythemia vera