Test 1 Flashcards

1
Q

What is genomics

A

The study of organization, function and evolution of genomes

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2
Q

Where are human genomes found

A

The nucleus

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3
Q

What are open reading frames

A

codons in a gene that encode the amino acid of the gene

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4
Q

What starts an open reading frame

A

Promotor

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5
Q

What is the human genome project

A

A project designed to publish the entire sequence of the human genome

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6
Q

What years the the HGP run

A

1990s-2003

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7
Q

What did the HGP accomplish

A

Basic sequence of human genome 3x10^9

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8
Q

what are introns

A

parts of an amino acid sequence that are dropped from translation…found between eons

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9
Q

what are exons

A

nucleotide sequence that remains in sequence through translation

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10
Q

alternative splicing

A

introns are dropped and exons are used to make protein

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11
Q

what is a gene and how many are in the human genome

A
  • most basic unit of genetics

- approx 20-25000

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12
Q

What does non-gene dna do

A

it is unclear what it does

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13
Q

why are only 450/1700 b-hemoglobin genes expressed

A

when introns are dropped you are left with hemoglobin

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14
Q

What is the process of making rna called and where is it done

A

In the nucleus

-transcription

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15
Q

what are the inputs of transcription

A

RNA polymerase

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16
Q

What are the outputs of transcription

A

polypeptides

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17
Q

after RNA is made what is the process that follows

A

translation

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18
Q

what are the products of these processes used for

A

differentiating different cells

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19
Q

What is the largest and smallest chromosome

A

1=largest

21=smallest

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20
Q

What is the largest class of genes

A

the unknown sector

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21
Q

What is a genetic map of human chromosomes

A

order of chromosomes and showing distance between them

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22
Q

how is a genetic map made

A

by probes which let us know specific genes

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23
Q

where does transcription take place and what is it

A

DNA-> RNA

-in the nucleus

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24
Q

where does translation take place and what is it

A

RNA->proteins

In the cytoplasm

25
which part of cell acts as barrier to genome and cytoplasm
nuclear envelope
26
which features of organism make up its karyotype
number, size, centromere location
27
male karyotype
22 pairs of autosomes xx
28
female karyotype
22 pairs of autosomes xy
29
homologous chromsome
xx
30
non-homologous chromsome
xy
31
what is an autosome
any non sex chromosome
32
how many chromosome haploid sets are in karyotype
23
33
how many dna strands are in diploid
46
34
what are the nitrogenous bases
adenine thiamine guanine cytosine
35
what is held with covalent bonds in dna
deoxyribose sugars | phosphates
36
what is held with hydrogen bonds in dna
nitrogenous bases
37
what creates the acidic features in dna
phosphate ions
38
what are nucleotides
phosphate sugar bases
39
what are polynucleotides
more than one nucleotide held together with bases
40
how does acidic nature influence linear structure
negative charge to phosphate repels dna
41
what bonds hold dna together
hydrogen bonds
42
how would you break apart bonds, whats this called
denaturalization | -heat to 60 degrees celsius
43
how is double stranded dna conserved during semi conservative replication
dna splits in 2 creating 2 templates
44
how does dna polymerase effect the replication
it uses the templates and copys them
45
what is the distance between base pairs
.34nm
46
how wide is the staircase and what is the diameter of the staircase
2nm
47
total length of human haploid genome...and diploid
1 meter | 2 meters
48
how many base pairs are in haploid genome...diploid?
3.2 billion hap | 6 billion dip
49
what is the total length of dna in the body
10-50 billion miles
50
how many times can your dna go to the sun and back
70
51
what can all your dna fit i
an ice cube
52
what is the molecular composition of chromosomes
50% dna-50% protein
53
non mitotic interphase
not condensed | -nuclear envelope present
54
mitotic interphase
condensed | -nuclear envelope not present
55
what is chromosome territory
every chromosome has its place so it can be compact
56
what is metacentric
having equal arms
57
submetacentric
short arms (P) with long arms (Q)
58
acrocentric
balls on top with short legs