Test 1 Flashcards
Tissue factor that is a cofactor
Factor VIII
Normal fibrin split product value
<10ug/dL
What initiates the coagulation cascade in vivo?
Tissue factor
In vitro, which zymogen is activated after collagen is exposed to blood?
Factor XII, Hageman Factor, Antihemophilic factpr D
Insufficient vWF most likely causes?
Insufficient clot adhesion
If a drug prolongs the TT and PT tests, which pathway is not affected?
Intrinsic pathway
First step of hemostasis process when an arterial vessel is damaged?
Vascular constriction
Natural anticoagulation affect of ADPase?
Limits ability to recruit more platelets
vWF is produced by?
Endothelial cells
Which of the following platelet surface receptors initially binds von Willebrand’s Factor to enhance platelet adhesion?
GP1b
Which of the following autologous anticoagulants involved in coagulation Termination is inactivated by Factor lla as part of a negative feedback?
Protein C
Which anticlotting substance works on Factors 5 and 8?
Protein C
4 serine processes inhibited by ATIII?
Activated Stuart factor
Antihemophilic factor B
Antihemophilic factor C
Antihemophilic factor D
Feasible therapy for ATIII deficiency
Transfusion of FFP
Administration of Atryn
Administration of Thrombate
What percent of patients with current DVT secondary to HIT Type II develop further thrombosis?
50%
DOC for HIT Type II
Argatroban
Which method of determining Protamine dose is most affected by Heparins half life?
Fixed dose
Advantage of using protamine titration method
Absence of heparin rebound
Which class of antibody mediates true Protamine anaphylactic reactions?
IgE
What is a high CVP on bypass associated with?
Impaired venous drainage
Ideal rate of UO on bypass?
0.5-1 ml/kg/hr
What causes an acute hemolytic reaction?
ABO incompatibility
Why is too much citrate dangerous?
It depletes K and Mg stores
RAP can remove how much prime?
200-600mL
