Test 1 Flashcards
Where are the 2 places to obtain blood for hematology?
- Periferal blood via venipuncture. 2. Bone marrow via bone marrow aspiration.
Bone marrow is aka?
Myeloid, myelogenous or intramedullary tissue.
What is the most common type of hematologic test?
Complete blood count CBC.
In a CBC which cells are biggest and smallest?
Biggest—> smallest; WBC, RBC, HGB, HCT, MCV, MCH, MCHC, RDW, Platelets.
List WBC from largest to smallest?
Neutrophils, Band, Lymphocytes, Monocytes, Eosinophils, Basophils.
What is hematopoiesis?
The formation and development of all types of blood cells from their parental precursors.
Where will a fetus’s hematopoiesis happen at?
Starts with yolk sack then moves to liver and spleen, then axial skeleton.
Where will an adult’s hematopoiesis happen at?
For the first few decades in the distal long bones and axial skeleton, and then later in life mainly the axial skeleton.
What is erythropoiesis?
Production of RBC and it is a type of hematopoiesis.
What will the cytoplasm color be like from beginning to the end of erythropoiesis?
It will start blue and eventually turn to orange.
During erythropoiesis it starts with a stem cell—> progenitor cell —-> ?
Rubriblast.
1 Rubriblast will eventually make how many RBC?
Many.
How long will erythropoiesis take?
5-6 days for bone marrow development.
What is the nucleus like during erythropoiesis?
It is present at the beginning and will disappear after 2-3 days.
What is the name of the first cell during erythropoiesis that will not have a nucleus?
Reticulocyte.
What part of erythropoiesis will cells enter the circulating blood?
Very promptly, even before the last maturational events have occurred as reticulocytes.
How long will a RBC last in circulation and what will happen to it?
120 days, senescence and destruction.
What is the last stage of RBC maturation that occurs after the nucleus is extruded in the bone marrow?
Reticulocyte.
Why are reticulocytes slightly larger than Mature RBC?
Because they are still maturing and contain residual fragments of cytoplasmic RNA and mitochondria.
Why will reticulocytes have a different color than mature RBC’s and what is the color?
Polychromatic from fragments of mitochondria.
When will reticulocytes finish maturing?
1-2 days after entering the peripheral circulation.
What % of circulating Red cells are reticulocytes?
0.5-2.5 %.
What are reticulocytes counts commonly used for?
Diagnosis of various anemia and in monitoring the recovery in factor deficiency anemias.
Will a CBC have a reticulocyte count?
No.