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MPT > Test 1 > Flashcards

Test 1 Flashcards

1
Q

What kind of group is shown here

A

Alkyl group

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2
Q

What kind of group is shown here?

A

Aromatic group

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3
Q

What kind of group is shown here?

A

Hydroxyl group

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4
Q

What kind of group is shown here?

A

Phenol

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5
Q

What kind of group is shown here?

A

Ether

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6
Q

What kind of group is shown here?

A

Ester

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7
Q

Is an alkyl group hydrophobic or hydrophilic?

A

Hydrophobic
(just a group of carbons)

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8
Q

Is an aromatic group hydrophilic or hydrophobic?

A

Hydrophobic
(a ring of C’s with alternating double bonds)

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9
Q

What makes a hydroxyl group hydrophilic?

A

The ability of the OH dipole to create a dipole dipole bond with WATER

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10
Q

Is a phenol hydrophobic or hydrophilic?

A

Hydrophilic
(an aromatic ring and an OH group that creates a dipole)

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11
Q

Why is an ether only weakly hydrophilic?

A

Because it has a dipole between the O and C but no OH group so it can not donate an H bond

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12
Q

Is an ester hydrophobic or hydrophilic?

A

Hydrophilic due to the resonance of the two O’s and the double bond

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13
Q

What are the boding capabilities of alkyl groups?

A

Vander Waals

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14
Q

What are the bonding capabilities of aromatic groups?

A

Vander Waals but specifically pi-pi stacking

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15
Q

What are the bonding capabilities of a hydroxyl group?

A

Dipole-dipole (hydrogen bonding)
Ion-dipole

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16
Q

What are the bonding capabilities of phenols?

A

Dipole-dipole
Hydrogen bonding
Pi-pi stacking (vander waals)

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17
Q

What are the bonding capabilities of an ether?

A

H bonding
Vander waals

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18
Q

What are the bonding capabilities of an ester?

A

H bonding
Van der Waals

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19
Q

Is an alkyl group an h bond acceptor or donator?

A

Neither

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20
Q

What is the pKa of alkyl group?

A

None

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21
Q

Is a hydroxyl group an h bond acceptor or donator?

A

Both but has no pKa or acidic properties

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22
Q

What is the pKa of a phenol?

A

9-10 (pKa is brought down due to the resonance of double bonds)

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23
Q

Is phenol an H bond acceptor or donator?

A

Both (weak acid)

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24
Q

Is an ether a h bond acceptor or donator?

A

Acceptor only
Does not have an H on the O

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25
Q

Is an ester an H bond acceptor or donator?

A

Acceptor only

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26
Q

What functional group is shown here?

A

Carboxylic acid

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27
Q

What functional group is shown here?

A

Aromatic ether

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28
Q

What bonding capabilities does a carboxylic acid have?

A

H bonding
Ion dipole

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29
Q

Is a carboxylic acid an H bond donor or acceptor

A

Both

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30
Q

What is the pKa of a carboxylic acid?

A

2-5

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31
Q

Is an aromatic ether acidic basic or neither?

A

Neither

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32
Q

Is an aromatic ether an H bond acceptor or donor?

A

Acceptor

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33
Q

What bonding capabilities does an aromatic ether have?

A

H bonding
Pi pi stacking

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34
Q

What functional group is shown here?

A

Aromatic ester

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35
Q

What functional group is shown here?

A

Sulfhydryl/ thiol

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36
Q

What functional group is shown here?

A

Thioether

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37
Q

What functional group is shown here?

A

Sulfonamide

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38
Q

What functional group is shown here?

A

Sulfonylurea

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39
Q

What functional group is shown here?

A

Alkyl amine

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40
Q

What functional group is shown here?

A

Aromatic amine

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41
Q

What functional group is shown here?

A

Aromatic heterocycle
Pyrrole

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42
Q

Is a carboxylic acid hydrophilic or phobic?

A

Hydrophilic

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43
Q

Is a thiol hydrophilic or phobic?

A

Hydrophilic

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44
Q

What bonding capabilities do aromatic esters have?

A

Pi pi stacking
H bonding

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45
Q

What are the bonding capabilities of a thiol?

A

H bonding

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46
Q

Is a thiol an h bond acceptor or donor

A

Both

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47
Q

Is a thiol acidic or basic and what is the pKa

A

Mildly acidic
10-11

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48
Q

Is a thioether hydrophilic or hydrophobic?

A

Hydrophilic

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49
Q

What are the bonding capabilities of a thioether?

A

H bonding
Vander Waals

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50
Q

Is a thioether an h bond acceptor or donor?

A

Acceptor

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51
Q

Is a thioether acidic or basic?

A

Neither

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52
Q

Is a sulfonamide hydrophilic or hydrophobic?

A

Hydrophilic

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53
Q

What bonding capabilities does sulfonamide have?

A

H bonding
Ion dipole

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54
Q

Is a sulfonamide an H bond acceptor or donor?

A

Both

55
Q

Is a sulfonamide an acid or a base?

A

Acid

56
Q

hat is the pka of a sulfonamide?

A

4-11 (resonance)

57
Q

Is sulfonylurea hydrophilic or hydrophobic?

A

Hydrophilic

58
Q

What are bonding capabilities of sulfonylurea?

A

H bond
Ion dipole

59
Q

Is a sulfonylurea an h bond acceptor or donor?

A

Both

60
Q

Is sulfonylurea acidic or basic

A

Acidic

61
Q

What is the pKa of a sulfonylurea?

A

5-6

62
Q

Is an alkyl amine hydrophobic or hydrophilic?

A

Hydrophilic

63
Q

Is aromatic amine hydrophilic or hydrophobic?

A

Hydrophilic

64
Q

Is pyrrole hydrophilic or hydrophobic?

A

Hydrophilic

65
Q

What are the bonding capabilities of an alkyl amine?

A

H bonding

66
Q

What are the bonding capabilities of an aromatic amine

A

H bonding
Ion dipole
Pi pi stacking

67
Q

What are the bonding capabilities of a pyrrole?

A

Pi pi stacking
H bonding
Ion dipole

68
Q

Is an alkyl amine an h bond acceptor or donor?

A

Both

69
Q

Is an aromatic amine an h bond donor or acceptor?

A

Both

70
Q

Is a pyrrole an h bond acceptor or donor?

A

Both

71
Q

Is an alkyl amine acidic or basic and what is its pKa?

A

Basic 9-11

72
Q

Is an aromatic amine basic or acidic and what is the pKa?

A

Weakly basic
2-5

73
Q

Is a pyrrole basic or acidic and what is the pKa?

A

Weakly basic
1-3

74
Q

What functional group is shown here?

A

Indole

75
Q

What functional group is shown here?

A

Imidazole

76
Q

What functional group is shown here?

A

Pyridine

77
Q

What functional group is shown here?

A

Amide

78
Q

What functional group is shown here?

A

Amidine

79
Q

What functional group is shown here?

A

Guanidine

80
Q

What functional group is shown here?

A

Carbamate

81
Q

What functional group is shown here?

A

Urea

82
Q

What functional group is shown here?

A

Carbonate

83
Q

Is an indole hydrophilic or hydrophobic?

A

Hydrophilic

84
Q

Is an Imidazole hydrophilic or hydrophobic?

A

Hydrophilic

85
Q

Is a pyridine hydrophilic or hydrophobic?

A

Hydrophilic

86
Q

Is an amide hydrophilic or hydrophobic?

A

Hydrophilic

87
Q

Is an amidine hydrophilic or hydrophobic?

A

Hydrophilic

88
Q

Is a guanidine hydrophilic or hydrophobic?

A

Hydrophilic

89
Q

Is a carbamate hydrophilic or hydrophobic?

A

Hydrophilic

90
Q

Is urea hydrophilic or hydrophobic?

A

Hydrophilic

91
Q

Is carbonate hydrophilic or hydrophobic?

A

Hydrophilic

92
Q

What are the bonding capabilities of an indole?

A

H bonding
ion dipole
pi pi stacking

93
Q

What are the bonding capabilities of imidazole?

A

H bonding
Pi pi stacking
Ion dipole

94
Q

What are the bonding capabilities of pyridine?

A

H bonding
Pi Pi stacking

95
Q

What are the bonding capabilities of amide?

A

H bonding

96
Q

What are the bonding capabilities of guanidine?

A

H bonding
Ion dipole

97
Q

What are the bonding capabilities of amidine?

A

H bonding
ion dipole

98
Q

What are the bonding capabilities of carbomate?

A

H bonding

99
Q

What are the bonding capabilities of urea?

A

H bonding

100
Q

What are the bonding capabilities of Carbonate?

A

H bonding

101
Q

H bond acceptor donor both or neither - indole?

A

both

102
Q

H bond acceptor donor both or neither - imidazole?

A

both

103
Q

H bond acceptor donor both or neither - pyridine?

A

acceptor

104
Q

H bond acceptor donor both or neither - amide?

A

Both

105
Q

H bond acceptor donor both or neither - guanidine?

A

Both

106
Q

H bond acceptor donor both or neither - amidine?

A

Both

107
Q

H bond acceptor donor both or neither - carbamate?

A

both

108
Q

H bond acceptor donor both or neither - urea?

A

both

109
Q

H bond acceptor donor both or neither - carbonate?

A

acceptor

110
Q

Acid basic neither and pka - indole?

A

Weakly basic 2

111
Q

H bond acceptor donor both or neither pKa - imidazole?

A

Highly basic 13-14

112
Q

H bond acceptor donor both or neither pKa - pyridine?

A

Weakly basic 5-6

113
Q

H bond acceptor donor both or neither pKa -amidine?

A

Basic 10-11

114
Q

H bond acceptor donor both or neither pKa - amide?

A

Neither

115
Q

H bond acceptor donor both or neither pKa - Guanidine?

A

Very basic 12-13

116
Q

H bond acceptor donor both or neither pKa - carbomate?

A

neither

117
Q

H bond acceptor donor both or neither pKa - urea??

A

neither

118
Q

H bond acceptor donor both or neither pKa - carbonate?

A

neither

119
Q

What interactions happen in vander waals?

A

Momentary uneven charges between carbons

120
Q

Are vander waals distant dependent or independent?

A

Very distant dependent

121
Q

What functional groups can do pi pi stacking?

A

Aromatic rings

122
Q

What is happening during dipole induced dipole?

A

Electrons are shifting in the molecule in molecule with dipole that creates a temporary dipole in the non dipole molecule

123
Q

What is the most common interaction of weak bonds?

A

Dipole dipole interactions

124
Q

What drugs would need to have covalent bonds?

A

Chemotherapy
Antifungal
Anti bacterial

125
Q

Why are covalent bonds toxic in the body?

A

They are not reversible so cannot be excreted

126
Q

What does pKa represent?

A

How well the molecule can stabilize a charge

127
Q

What is solvation and dissolution?

A

ability to be solvated and dissolved in the body

128
Q

Where do hydrophilic drugs go in the body?

A

In the plasma
Plasma is majority water

129
Q

What is a negative of a hydrophilic drug?

A

The drug cannot cross the membrane to be metabolized

130
Q

Does a hydrophilic drug have high or low levels of excretion?

A

High

131
Q

Does a hydrophilic have a long or short duration of action?

A

short

132
Q

Where do hydrophobic drugs go in the body?

A

To the fatty parts of the body
Go to albumin in the blood

133
Q

Which drug has a higher volume of distribution- hydrophilic or hydrophobic?

A

Hydrophobic

134
Q

What is metabolism?

A

The body getting rid of things that arent itself like a drug

MPT (5 decks)

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