Test 1 Flashcards
Phospholipid layer with associated integral and peripheral proteins
Plasma membrane
The lipid bilayer consists of:
Phospholipids, cholesterol, glycolipids
Amphipathic
Having both polar and nonpolar parts
Mediates membrane fluidity in the bilayer
Cholesterol
Allow specific ions to move through water filled pore
Ion channels (integral)
Carry specific substances across membrane by changing shape
Carriers (integral)
Recognize specific ligand and alter cell’s function
Receptor (integral)
Catalyze reaction inside or outside cell and splits (hydrolysis) molecules
Enzymes (integral and peripheral)
Anchors filaments in/outside of plasma membrane
Linkers (integral and peripheral)
Glycoprotein that distinguishes cells from other cells
Cell-identify markers
Where is the glycocalyx found?
On the outside of the plasma membrane
Equal concentration of solutes
Isotonic
Lower concentration of solutes
Hypotonic
Higher concentration of solutes
Hypertonic
Secondary Active Transport
Energy stored in Na+ or H+ concentration gradient drives other substances against their concentration gradient
Antiporters
Carry two substances across cell membrane in opposite directions
Symporters
Carry two substances across cell membrane in same direction
Cancerous neoplasm (tumor) that tends to metastasize
Malignancy
Neoplasm that doesn’t metastasize
Benign tumor
Malignant neoplasm (tumor) that arises from epithelial cells
Carcinoma
Cancerous growth of melanocytes
Melanoma
Cancer arising from muscle cells/connective tissue
Sarcoma
Cancer of bone
Osteogenic sarcoma
Science that deals with why, when, where diseases occur
Epidemiology
Decrease in size of cells, tissue or organ
Atrophy
Alteration in size, shape, organization of cells due to chronic irritation/inflammation
Dysplasia
Increase in number of cells in a tissue due to increase in frequency of cell division
Hyperplasia
Increase in size of cell without cell division
Hypertrophy
Study of proteome (organism’s proteins)
Proteomics
Carrier of genetic information: single, double stranded DNA molecule
Chromasome
Two molecules of double stranded DNA joined in the center by a centromere
Chromatid
Ordinary chromosome that doesn’t determine sex
Autosome
Chromosome with same linear sequence of genes, look alike, pair during meiosis
Homologous chromosome
DNA sequence at tips of chromosomes
Telomere
Number of chromosomes
Number of gametes
46
23
Copying of specific DNA to produce mRNA
Transcription
Assembly of new protein molecule using its amino acid building blocks (specified my mRNA)
Translation
When an individual is born with chromosomes added or missing
Aneuploidy
Cell missing 1 chromosome
Monosomy
Cell has additional chromosome
Trisomy
Rh factor incompatibility causes what disease in second pregnancy?
Hemolytic disease
Symbology for Turner Syndrome
45, XO
Symbology for Klinefelter syndrome
47, XXY
Symbology for Down’s syndrome
47, XX, +21
Types of nondisjunction
Monosomy (loss of chromosome)
Trisomy (gain of chromosome)
Transmembrane glycoproteins called cadherin attach to plaque, plaque attaches to microfilaments (actin)
Adherins junctions
Transmembrane glycoproteins (cadherin) attach to plaque, plaque attached to intermediate filaments (keratin)
Desmosomes
Transmembrane glycoproteins called integrin attach plaque to basement membrane, plaque attaches to intermediate filaments (keratin)
Hemidesmosome
Transmembrane proteins called connexins form connexon channels between plasma membranes
Gap junctions
Free surface of epithelial tissue is called ________
Apical
The basal layer of the epithelium secretes ____________; the underlying C.T. secretes ____________
Basal lamina, reticular lamina
Transitional epithelium is found in the ___________
Bladder
Merocrine glands secrete products by ___________
Exocytosis
Apocrine glands secrete their products by ___________
Budding/decapitation
Holocrine glands release their secretions by
Rupturing plasma membrane
Inelastic, flexible fibers arranged in parallel bundles; most abundant protein in the body
Collagen
Fine bundles of collagen coated with glycoprotein; form stroma of soft organs
Reticular fibers