TERMS Flashcards
Prospective payment system
Instead of per service fees, a capitated fee is set for the general course of treatment
Donut hole of Medicare Part D
After you have spent a certain amount of money and after your Medicare plan has spent a certain amount of money you must pay fees out of pocket for a certain amount of time
Mental health in Medicare
Mental health services are equal to other hospital stays
Boolean operators
AND searches for overlap
OR used between synonyms
Order of specificity of sources from least to most specific
Encyclopedias, books, review articles, journal articles, conference proceedings/meeting abstracts
Review articles
Considered secondary sources and review existing research and summarize the state of knowledge on the topic
Tricks and tips of searching on google
“Primary care” in quotes to search for the whole phrase together
Truncation:
Depress* searches for depressed OR depressing OR depression
Parkin
Promotes cellular garbage disposal
Cells try to refold it protein with backup strategy as disposal
Broken or mutated Parkin correlated with early onset Parkinson’s disease
More Parkin?
Reduces the accumulation of toxic proteins during age
Increases healthy lifespan
Aging is a result of
Defective cellular garbage disposal
Intestinal barrier distinction
Physiological bio marker of aging
Anti aging strategies
Clean up cellular garbage, increase mitochondrial activity
Diagnostic related groupings
Fixed Medicare prices for certain treatments and diagnostic category and expected length of stay of the patient
Smallpox
Eradicated in 1980 by Edward Jenner who created the vaccine in 1796 for it
Integumentary system
(Skin)
Epidermis, dermis, subcutaneous fat
Epidermis
Keratinocytes - wound healing and utilize vit D
Melanocytes - make melanin
Langerhans cells - mast cells - release histamine in allergic reactions
Dermis
Collagen, elastin, blood vessels, lymphatics, mast cells, hair follicles
Subcutaneous fat
Mainly used for fat storage
Has fibroblasts, adipose cells, and macrophages
How does skin change as we age?
Keratinocytes divide less frequently thus leading to slower wound healing.
Dermis becomes much thinner and more sensitive.
Diseases hat accompany aging: tumor of melanocytes, skin cancer
As you age what happens to the innate immune system
Increase in NK
Increase in inflammatory cytokines
Decrease in dendritic cells
Aging B cell changes
Increase in autoantibodies
Decrease in quality of regular antibodies
Cytotoxic T cells
Recognize virus on infected cells and kill those cells
Thymus
Begins to shrink starting in childhood as fewer naive or new T cells are produced
Referred to as thymine involution - less naive or clean slate T cells produced and more specialized T cells that are specific to certain cells are present
How does thymidine involution affect aging
Decrease in ability to produce naive T cells means that older people are less likely to be able to recognize viruses from newer diseases
T cell changes
Increase in memory T cells
Decrease in naive T cells
Increase in proportion of senescent T cells (no CD28, short telomeres unable to divide, poor killing, increase inflammatory state -TNF and IL6
HIV and CD28-
HIV patients also show high amounts of senescent T cells because chronic simulation of the immune system results in an increase of cells lacking CD28-
Flu vaccine
Not optimized for older people lacking naive T cells and high proportion of senescent T cells
-36,000 deaths, 400,000 hospitalization a
90% of deaths are in elderly
Cytomegalovirus
Lots of T cells see CMV and so decrease in naive T cells for other antigens
Preventative vaccines
Measles, mumps, rubella (MMR) Pneumococcus Influenza HPV (cervical, penal, anal, head and heck cancer) NONE for Malaria
Therapeutic vaccines
Reduce disease severity but not prevent it
HIV
TB
cancer vaccines
Bone effect with aging
Increase in inflammatory cytokines causes bone loss and osteoporotic fractures
Cells responsible for homeostasis
10% of skeleton replaced every year
Osteoclasts- resorb old bone
Osteoblasts -create new bone
As we age more osteoclasts than blasts destructing more bone and creating less
Osteopenia
Reduced bony density not a disease