Terms

Question 1

Plasmin

Answer 1

the proteolytic enzyme that mediates fibrinolysis.

Question 2

Plasminogen

Answer 2

the inactive precursor form of plasmin that is found in plasma.

Question 3

Homeostasis

Answer 3

the state of steady internal conditions maintained by the body.

Question 4

Hemostasis

Answer 4

the cessation of free blood flow, external to the vascular system, when a vessel wall has been breached.

Question 5

Vasoconstriction

Answer 5

narrowing of a blood vessel lumen that takes place after injury to the vessel.

Question 6

Primary Hemostasis

Answer 6

the process of a platelet plug in a damaged vessel.

Question 7

Secondary Hemostasis

Answer 7

the series of interrelated chemical processes that lead to the formation of durable fibrin strands and incorporation into the platelet plug.

Question 8

Intrinsic Coagulation pathway

Answer 8

initiated by the exposure of contact factors and subendothelial tissue. In addition to the contact factors (XII, XI, prekallikrein, and high-molecular-weight kininogen), this pathway includes factors IX and VIII. Ultimately, when activated, this pathway activates factor X which is the beginning of the common pathway.

Question 9

Extrinsic Coagulation pathway

Answer 9

activated when tissue factor comes into contact with blood, activating factor VII. This activates factor X, which is the beginning of the common pathway.

Question 10

Common Coagulation Pathway

Answer 10

begins with factor X. Factor X can be activated by either the intrinsic or extrinsic pathway.

Question 11

Fibrinolysis

Answer 11

the process by which fibrin is broken down and removed from the clot.

Question 12

Prothrombin Time (PT)

Answer 12

screening test that helps assess the functionality of both the extrinsic and common pathways.

Question 13

INR

Answer 13

International Normalized Ratio

Question 14

APTT

Answer 14

a screening test that assesses functionality of both the intrinsic and extrinsic pathways.

Question 15

PFA

Answer 15

platelet function assay

Question 16

Platelet Function Assay (PFA)

Answer 16

screening test for evaluation of PLTs/primary hemostasis.

Question 17

Hemophilia A

Answer 17

deficiency of coagulation factor VIII.

Question 18

Hemophilia B

Answer 18

deficiency of coagulation factor IX.

Question 19

Von Willebrands Disease (vWFD)

Answer 19

PLT disorder due to a defect in von Willebrands factor.

Question 20

Disseminated Intravascular Coagulation (DIC)

Answer 20

a disorder of consumption of the clotting factors and depletion of them from the blood.

Question 21

Bernard-Soulier Syndrome (BSS)

Answer 21

genetic PLT disorder W/ abnormal PLT function, and unusually large PLTs.