Terminology

Question 1

Neuromodulator

Answer 1

Released by neurons or astrocytes. Produces slower pre and/or post synaptic effects.

Question 2

Agoinst

Answer 2

Binds to receptor to elicit a response.

Question 3

Affinity

Answer 3

Tendency of drug to bind to receptor.

Question 4

Efficacy.

Answer 4

Ability of drug, once bound to receptor, to elicit a response.

Question 5

Full Agonist

Answer 5

Produces maximum response which a tissue is capable of.

Question 6

Partial Agonist.

Answer 6

Can’t produce maximum response - even when occupying all receptors.

Question 7

Antagonist.

Answer 7

Does not elicit a response but prevents agonist from eliciting response.

Question 8

Competitive Antagonist

Answer 8

Antagonist that binds to agonist binding site to prevent agonist binding. If it is reversible - increasing concentration of agonist will overcome effects of antagonist.

Question 9

Non-Competitive Antagonist.

Answer 9

Antagonist that interferes with the transduction process between agonist binding and response.

Question 10

Ionotropic Receptor

Answer 10

Ligand-gated ion channel.

Question 11

Metabotropic receptor

Answer 11

Produces its response through a second messenger.

Question 12

Allosteric Modulators

Answer 12

Binds to sites on the receptor (other than the agonist binding site) to modify agonist activity (either affinity or efficacy)

Question 13

Inverse Agonist.

Answer 13

Binds to intrinsicly active receptor and changes receptor to inactive state. Commonly produces opposite response to agonists.

Question 14

Neurotransmitter

Answer 14

Released by a pre-synaptic neuron. Produces rapid excitation or inhibition of post-synaptic neuron.

Question 15

*

Released by neurons or astrocytes. Produces slower pre and/or post synaptic effects.

Answer 15

Neuromodulator

Question 16

*

Binds to receptor to elicit a response.

Answer 16

Agoinst

Question 17

*

Tendency of drug to bind to receptor.

Answer 17

Affinity

Question 18

*

Ability of agonist, once bound to receptor, to elicit a response.

Answer 18

Efficacy.

Question 19

*

Produces maximum response which a tissue is capable of.

Answer 19

Full Agonist

Question 20

*

Can’t produce maximum response - even when occupying all receptors.

Answer 20

Partial Agonist.

Question 21

*

Does not elicit a response but prevents agonist from eliciting response.

Answer 21

Antagonist.

Question 22

*

Antagonist that binds to agonist binding site to prevent agonist binding. If it is reversible - increasing concentration of agonist will overcome effects of antagonist.

Answer 22

Competitive Antagonist

Question 23

*

Antagonist that interferes with the transduction process between agonist binding and response.

Answer 23

Non-Competitive Antagonist.

Question 24

*

Ligand-gated ion channel.

Answer 24

Ionotropic Receptor

Question 25

*

Produces its response through a second messenger.

Answer 25

Metabotropic receptor

Question 26

*

Binds to sites on the receptor (other than the agonist binding site) to modify agonist activity (either affinity or efficacy)

Answer 26

Allosteric Modulators

Question 27

*

Binds to intrinsicly active receptor and changes receptor to inactive state. Commonly produces opposite response to agonists.

Answer 27

Inverse Agonist.

Question 28

*

Released by a pre-synaptic neuron. Produces rapid excitation or inhibition of post-synaptic neuron.

Answer 28

Neurotransmitter