Teratology And Drugs In Pregnancy

Question 0

Increased free drugs d/t decreased plasma albumin concentration

Answer 0

Diazepam, phenytoin, valproate, warfarin

Question 1

Effect of prolonged gut transit time on absorption

Answer 1

Increased absorption

Question 2

Drugs with increased elimination d/t increased renal blood flow in 3rd trisem

Answer 2

Ampicillin
Gentamicin
Digoxin:heart failure
Phenytoin
Carbamazepine
Valproic acid
Lithium

Question 3

Enzymatic changes

Answer 3

Increased CYP 3a4, 2d6, 2c9:NSAIDs, calcium. Channel blockers
Decreased cyp1a2(theophylline), 2c19(phenobarbital)

Question 4

Placenta metabolizes

Answer 4

Pentobarbital.

Create toxic metabolites: ethanol

Question 5

Causes adenocarcinoma of cervix and vagina if taken <18 wks AOG

Answer 5

Diethylstilbestrol

Question 6

Only US FDA approved indicationw for thalidomide

Answer 6

Erythema nodosum leprosum
Mutiple sclerosis
AIDS

Question 7

Percentage of pregnancies with babies having an anatomic abnormality

Answer 7

2-3%

Question 8

To be considered teratogenic

Answer 8

Results in a set of malformations
Exert effects at a particular stage of devlpt
Dose dependent incidence

Question 9

Tobacco causes

Answer 9

SGA

IUGR

Question 10

Diabetes mellitus causes

Answer 10

Large for gestational age babies

Macrosomia-> difficult delivery-> fractured clavicle

Question 11

Babies with rubella

Answer 11

Cataract
Microcephaly
PDA

Question 12

Congenital minamata disease manif and cause

Answer 12

D/t methymercury

MR, malformed head and teeth

Question 13

Max limit for ionizing radiation

Answer 13

150 mSv
CT scans:10-50 mSv
Xray: 0.1

Question 14

Drugs that disrupt folic acid absorption/metab

Answer 14

Carbamazepine
Lamotrigine
Phenobarb
Hydantoin
Valproic acid

Question 15

Pregnancy induced HTN

Answer 15

Hydralazine

Question 16

Causes fetal goiter

Answer 16

Iodine/iodine containing compounds

Question 17

AE of systemic steroids esp during 1st trisem

Answer 17

Cleft lip/palate

Question 18

anti epileptic drugs are FDA category ?

Answer 18

FDA D

Question 19

Phenytoin causes what syndrome

Answer 19

Fetal hydantoin syndrome: broad nasal bridge, hypertelorism(abn inc in interorbital distance), epicanthal folds, blepharoptosis(drooping upper eyelid), strabismus, low-set deformed ears

Question 20

AE of sex hormones during pregnancy

Answer 20

Microtia

Question 21

AE of misoprostol

Answer 21

Associated with mobius syndrome(facial paralysis, inability to move eyes fr side to side, of normal imtelligence)