Teratology Flashcards
Meaning of terratos
Monster
Principles of teratology( key terms )
Genotype of the conceptus Time of exposure Mechanism Manisfeastation Amount/ dose of teratogen
Mechanism of teratogens
Inhibition and enhance cell proliferation
Most critical time of exposure
Third to eight AOG
Causative agent of German measles
Rubella virus
Causative agent of syphilis?
T. pallidum
Causative agent of Chicken pox?
Varicella zoster virus
Causative agent of measles?
Rubeola virus
Classic representations of CMV infection?
Microcephaly and visual impairment
T/F Rubella causes Cataract
True
Causes limb hypoplasia and skin scarring?
VzV
Transmitted from soil contaminated feces from domsticated animals especially cats
Toxoplasma gondii
Threshhold for abnormality in X-ray
200 rads
Effect of x-ray?
Kills rapidly proliferating cells
Immunomodulatory drug than cause limb defect?
Thalidomide
Anti-neoplastic drug that causes anencephaly and cleft lift
Aminoptherin
Anti-seizure drug causing fetal hydantiin syndrome and facial defect?
Diphenylhydantoin
Drug that causes neural tube defect
Valproic acid
Causes urogenital and skeletal abnormalities
Trimethadione
Malformation caused by lithium
Heart malformation
SSRI stands for? And is considered as what type of drug?
Selective serotonin re-uptake inhibitor; anti depressant
Diagnosis of thecroen rump length uses what
ULTRASONOGRAPHY
Fetal age and growth assesses 3 noted bones:
Buparietal diameter of skull
Femur length
-non bone abdomenal circumflex
Increase AFP indicates
NTD, spina bifida
Low AFP
Trisomy 21
A byproduct of CNS Development
ALPHA FETOPROTEIN
Omphalocele is diagnosed using
UTZ
Study for chromosomal error
Chorionic villus sampling
Amount of chorionic villus sample to be collected?
5-30 mg
Amount collected in amniocentesis
20-30mL
Amnicentesis is aided by?
UTZ
Result of Amniocentesis are released after
1-2weeks
It is present where fluid accumulated when down syndrome are present
Nuchal transluscency
