Teratogens Flashcards
ACE Inhibitors
Fetal renal tubular dyspolasia and neonatal renal failure
oligohydramnios
IUGR
lack of cranial ossification
Alcohol
Fetal alcohol syndrome (growth restriction before and after birth, mental retardation, midfacial hypoplasia, renal and cardiac defects). Consumption of > 6 drink per day is associated with a 40% risk of FAS
Androgens
virilization; advanced genital development in males
carbamazepine
neural tube defects fingernail hypoplasia microcephaly developmental delay IUGR
cocaine
bowel atresia congential malformation of the heart, limbs, face and GU tract microcephaly IUGR cerebral infarctions
diethystilbestrol
clear cell adenocarcinoma of the vagina or cervix
vaginal adenosis
abnormalities of the cervis and uterus of testes
possible infertility
lead
increase SAB rate
stillbirths
lithium
congenital heart disease (ebstein’s anomaly)
methotrexate
increased SAB rate
organic mercury
cerebral atrophy microcephaly mental retardation spasticity seizures blindness
phenytoin
IUGR mental retardation microcephay dysmorphic craniofacial features cardiac defects fingernail hypoplasia
radiation
microcephaly
mental retardation
medical diagnostic readiation delivering < 0.05 Gy to the fetus has no teratogenic risk
streptomycin and kanamycin
hearing loss
CN VIII damage
tetracycline
permanent yellow-brown discoloration of deciduous teeth
hypoplasia of tooth enamel
thalidomide
bilateral limb deficiecies
anotia and microtia
cardiac and GI anomalies