Teratogens Flashcards

1
Q

ACE Inhibitors

A

Fetal renal tubular dyspolasia and neonatal renal failure
oligohydramnios
IUGR
lack of cranial ossification

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2
Q

Alcohol

A

Fetal alcohol syndrome (growth restriction before and after birth, mental retardation, midfacial hypoplasia, renal and cardiac defects). Consumption of > 6 drink per day is associated with a 40% risk of FAS

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3
Q

Androgens

A

virilization; advanced genital development in males

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4
Q

carbamazepine

A
neural tube defects
fingernail hypoplasia
microcephaly
developmental delay
IUGR
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5
Q

cocaine

A
bowel atresia
congential malformation of the heart, limbs, face and GU tract
microcephaly
IUGR
cerebral infarctions
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6
Q

diethystilbestrol

A

clear cell adenocarcinoma of the vagina or cervix
vaginal adenosis
abnormalities of the cervis and uterus of testes
possible infertility

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7
Q

lead

A

increase SAB rate

stillbirths

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8
Q

lithium

A

congenital heart disease (ebstein’s anomaly)

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9
Q

methotrexate

A

increased SAB rate

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10
Q

organic mercury

A
cerebral atrophy
microcephaly
mental retardation
spasticity
seizures
blindness
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11
Q

phenytoin

A
IUGR
mental retardation
microcephay
dysmorphic craniofacial features
cardiac defects
fingernail hypoplasia
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12
Q

radiation

A

microcephaly
mental retardation
medical diagnostic readiation delivering < 0.05 Gy to the fetus has no teratogenic risk

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13
Q

streptomycin and kanamycin

A

hearing loss

CN VIII damage

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14
Q

tetracycline

A

permanent yellow-brown discoloration of deciduous teeth

hypoplasia of tooth enamel

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15
Q

thalidomide

A

bilateral limb deficiecies
anotia and microtia
cardiac and GI anomalies

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16
Q

treimethadione and paramethadione

A

cleft lip or cleft palate
cardiac defects
microcephaly
mental retardation

17
Q

valproic acid

A

neural tube defects (spina bifida); minor cranciofacial defects

18
Q

vitamine A and derivatives

A
increase SAB
microtia
thymic agenesis
cardiovascular defects
craniofacial dysmorphism
micropthalmia
cleft lip or cleft palate
mental retardation
19
Q

Warfarin

A

nasal hypoplasia and stippled bone epiphyses
developmental delay
IUGR
opthalmologic abnormalities