Teratogenic drugs

Question 1

NSAIDs in preg

Answer 1

Teratogenic in T3

1. Premature closure of PDA
2. Pulm HTN to baby

Question 2

Epileptic drugs and teratogenicity

Answer 2

1. CARBAMAZEPINE - safer
   - causes spina bifida
2. Phenytoin
   -Cleft lip, palate
   -Congenital heart disease
3. Sodium valproate - not used
   -spina bifida

4 Lamotrigene - currently used
Levetiracetam

*Anti epileptics - small dose in breast milk but do not stop feeding

*Higher oestrogen OCP as anti epileptics increase liver enzyme activity