Teratogenic Agents Flashcards
Midazolam
Cleft Palate
Cocaine
Growth retardation
Safe
volatiles (not N2O?)/opioids/paralytics/barbiturates/propofol
N2O?
Nitrous oxide is the only inhaled anesthetic that has been shown to be teratogenic to experimental animals, although this was at high concentrations for prolonged periods. It appears that nitrous oxide may inhibit DNA synthesis through its effects of the inhibition of methionine synthase.
Others: A
ACE-i, Alcohol, Androgens, Antithyroid drugs
Others: C
carbamezepine, chemotherapeutic agents, cocaine, coumadin
Others: D
diethylstilbestrol
More: L/M/P/R/S
lead, lithium, mercury, phenytoin, radiation (>0.5 Gy), streptomycin/kanamycin,
T’s
tertracycline, thalidomide, trimethadione,
V’s
valproic acid, vitamin A derivatives