Teratogenesis

Question 1

Cartilage Damage

Answer 1

Levofloxacin

Question 2

Discoloured teeth

Answer 2

Tetracycline

Question 3

Ebstein anomaly

Answer 3

Lithium

Question 4

Holoprosencephaly

Answer 4

Ethanol (Alcohol)

Question 5

Limb hypoplasia

Answer 5

Thalidomide, Cyclophosphamide

Question 6

Spine bifida

Answer 6

Carbamazepine, Valproic acid

Question 7

Ototoxicity

Answer 7

Gentamicin (Aminoglycosides)

Question 8

Neural tube defects

Answer 8

Methotrexate

Question 9

Fetal hydantoin syndrome

Answer 9

Phenytoin

Question 10

Spontaneous abortions

Answer 10

Isotretinoin

Question 11

Clear cell vaginal adenocarcinoma

Answer 11

Diethylstilbestrol (DES)

Question 12

Cause of Intrauterine Restriction syndrome from decreased blood flow to fetus?

Answer 12

Cocaine or Tobacco

Question 13

Category X drugs (list)

Answer 13

Methotrexate
Statins
Warfarin
Isotretinoin
Diethystilbestrol (DES)
Thalidomide

Question 14

Time at which a fetus is MOST susceptible to teratogens?

Answer 14

Organogenesis (Weeks 3-8)

Question 15

What week does the 4-chambered heart begin to develop?

Answer 15

Week 4 (4 chambers, week 4)

Question 16

What week does genitalia begin to take on a visible sex-specific characteristics?

Answer 16

Week 10

Question 17

What week does fetal movement begin?

Answer 17

Week 8 (“Gait rhymes with 8”)

Question 18

What week do limb buds begin to develop?

Answer 18

Week 4 (4 limbs, week 4)

Question 19

Most common cause of neural tube defects?

Answer 19

Folate deficiency

Question 20

Most common cause of congenital malformation in the U.S.?

Answer 20

Alcohol use

Question 21

Most common cause of congenital intellectual disability in the U.S.?

Answer 21

Fetal alcohol syndrome

Question 22

Clinical features of Fetal Alcohol Syndrome?

Answer 22

Smooth philtrum
Thin upper lip
Small palpebral fissues with wide set eyes
Developmental delay
Intellectual disability