Technical services Flashcards
State what aseptic pharmacists do
management
Record keeping and Quality issues
Professional:
Clinical
Protocols and regimens
Medicines info & education
Advice on special situations
Trials and research / audit
‘Usual’ pharmacist roles as well!
State facts about guidelines and record keeping in the aseptic unit
Batch manufacture and paperwork
Compliance with guidelines on operating and maintaining equipment
ML requirements
Facts about Quality Assurance
ESSENTAIL part of ML
Must ensure quality of:
Equipment (servicing!)
Accuracy of labelling and dispensing
Particles in air
Microbes in environment
Microbes, particles in products
Volume / concentration of products
Etc
Facts about cytotoxic prescribing
Most drugs mg/ m2 prescribing.
Calc of Body surface area – (BSA) uses height and weight.
Online calculators, part of electronic Rx.
E.g. 1.75 m tall, weight 75 kg = 1.91 m2
Average approx. 1.6-1.7 m2
Drug doses individualised based on this
Facts about medicine information role
Advice to:
Pharmacy staff
Clinicians and nurses, including training!
Patients
Specialist advice on:
Regimens
Drugs and diluents
Drug administration
Storage and expiry
Adjuvant drugs
Medicine management issue
Oxaliplatin
Look in BNF appendix 6
“ Continuous in glucose 5%
Dilute requisite dose to a concentration of 200-700 mcg/mL and give over 2-6 hours. Incompatible with alkaline or chloride-containing fluids; avoid equipment containing aluminium.”
So cannot give in NaCl, must be diluted and must be given as a long infusion.
What is extravasation Injury
leakage of drug into tissue causing
pain, irritation, tissue damage
dependent on the drug
Minor extravasating injury presents as
redness, swelling
Major extravasating injury presents as
loss of a limb, loss of function
(potent vesicants or irritants)
State how to manage drug toxicity
stop drug if still running
remove cannula only after marking & aspiration
hydrocortisone iv & local & topical
antidote ? (caution)
cover site immediately with gauze
heat or cool according to nature of agent
complete incident form & extravasation sheet
Facts about Carboplatin dose calculation
Carboplatin – Pt compound, licensed for ovarian and small cell lung carcinoma.
Very toxic, GI, renal, neuro,ototoxic.
Mainly renal clearance
Use Calvert formula – relates CrCl to AUC to determine dose:
AUC = GFR (mLs/min) + 25 mLs/min
Use multiple of AUR as dose e.g. previously untreated ovarian cancer, single agent carboplatin,
dose = 5 x AUC
State facts about product expiry date
ood practice to give all individually manufactured doses a 24 hour expiry as ensures not ‘left around’ on ward.
Many products known to be more stable
May provide advice on extending expiry times/dates.
E.g. MTX 50mg/mL (preserved) stable in syringes for 8/12 at 25 C !
E.g. 5-FU 10mg/mL stable in some pumps for up to 16 weeks at 25 C ! (NB normally give 8/7 exp)