TDM Flashcards
Note: therapeutic drug monitoring involves measuring trunk concentrations in biological fluids to:
- Assess therapeutic compliance
- Evaluate efficacy
- Investigate drug-induced toxicity
Note: therapeutic drug monitoring involves measuring trunk concentrations in biological fluids to:
- Assess therapeutic compliance
- Evaluate efficacy
- Investigate drug-induced toxicity
The study of how genetic variations affect drug response
pharmogenomics
examines genetic variations influencing short response and can guide medication situation and dozing
pharmacogenetic testing
Factors affecting drug stability in the sample includes____ and ____ we considered during handling
temperature and storage conditions
Deals with the relationship between drug concentration in the receptor site in response of tissues to the drug
pharmacodynamics
Deals with the relationship between the drug dose and drug blood
levels/how the body handles the drug
pharmacokinetics
Lowest concentration of the drug is expected
Trough
Collected when the highest the concentration of the drug is expected
peak
Time required to reduce the drug into half of its original concentration
half-life
time in which the concentration of the drug in the body stays consistent
steady state
Fraction of drug that reaches the blood or the circulation
bioavailability
Measures how selective the drug is in producing the desired effect
Therapeutic index
Lowest concentration of child in the blood that will produce desired affect
Minimum dose effet
Lowest concentration of the drug in the blood that will produce adverse effect
Minimum lethal dose
Treatment for congestive heart failure and atrial fibrillation flatter