TCR DEVELOPMENT & MATURATION

Question 1

What instructs common lymphoid progenitors to commit to Tcell lineage?
A-c-kit/SCF
B-CD34
C-IL-7/IL7R
D-Notch 
E-IFN-gamma

Answer 1

Notch signals in the thymus cortex

Question 2

what directs TCR gene rearrangement?

Answer 2

IL7/IL-7r and c-kit/SCF

Question 3

what blocks the beta chain rearrangement and allows for γδ rearrangement creating γδ+CD3+CD4-CD8-?

Answer 3

Strong Erk blocks β chain rearrangement