TCAs

Question 1

Tertiary amines

Answer 1

Amitriptyline
Clomipramine
Imipramine
Doxepin
Amoxapine

Question 2

Secondary amines

Answer 2

Desipramine
Nortriptyline
Maprotiline

Question 3

MOA of TCAs

Answer 3

Inhibits reuptake of both serotonin and NE which leads to increased concentration of these neurotransmitters in the synapticc elect

Question 4

indications for TCAs

Answer 4

depression
insomnia
neuropathies
pain disorders
Insomnia and anxiety due to sedating effects

Question 5

What TCA is approved for OCD

Answer 5

Clomipramine (if older than 10)

Question 6

ADE of TCAs

Answer 6

Anticholinergic MC
sedation/drowsiness, increased appetite, weight gain, confusion (due to antihistamine effects)
Orthostatic hypotension, dizziness (due to alpha-1 adrenergic receptor blockade)
sexual dysfunction
prolonged QT interval

Question 7

What is the best indicator for an overdose of TCA

Answer 7

prolonged QT interval

Question 8

Overdose 3C’s for TCAs

Answer 8

Cardiotoxicity
Coma
Convulsions (lowers seizure threshold)

Question 9

How do you treat cardio toxicity from TCAs

Answer 9

sodium bicarbonate

Question 10

which TCAs are the most anticholinergic

Answer 10

Amitriptyline
Doxepin