TCA CYCLE REGULATION

Question 1

Pyruvate → Acetyl-CoA

Answer 1

Inhibitory: ATP, AcetylCoA, NADH, Fatty Acids

Stimulatory: AMP, CoA, NAD+, Ca2+

Question 2

Oxaloacetate →(Acetyl-CoA)→ CItrate

Answer 2

Inhibitory: NADH. Succinyl-CoA, Citrate, ATP

Stimulatory: ADP

Question 3

Isocitrate → α-Ketoglutarate

Answer 3

Inhibitory: ATP

Stimulatory: ADP, Ca2+

Question 4

α-Ketoglutarate → Succinyl-CoA

Answer 4

Inhibitory: Succinyl-CoA, NADH

Stimulatory: Ca2+

Question 5

Rate of the TCA cycle is limited by the availability of the intermediaries, name the 3 intermediaries.

Answer 5

1. Acetyl-CoA
2. Oxaloacetate
3. α-Ketoglutarate