TB9 - Action and Decision Flashcards

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1
Q

What is dystonia?

A

This is a movement disorder in which a person’s muscles contract uncontrollably

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2
Q

Where are upper motor neurons found?

A

The motor cortex

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3
Q

What occurs in the motor cortex?

A

Planning, initiating and directing voluntary movements

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4
Q

What occurs in the brainstem centres?

A

Basic movements and postural control

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5
Q

What does the cerebellum control?

A

Sensory motor coordination

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6
Q

Give examples of a simple reflex

A

Stretch reflex and knee jerk, mediated at the spinal cord

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7
Q

Give examples of posture and postural change

A

Standing and balancing

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8
Q

Give examples of locomotion

A

Walking and running

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9
Q

Give examples of sensory orientation

A

Head turning and eye fixation

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10
Q

Give examples of species specific action patterns

A

Ingestion, courtship, escape/defence, grooming

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11
Q

Give examples of acquired skills

A

dressing, painting, driving, sports, texting, instruments

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12
Q

What is leprosy?

What happens in leprosy and what are the effects?

A

A disease caused by a bacterium infection.
Peripheral nerves thicken, interrupting signals.
Thermal sensations, pain and touch slowly fade, which can result in severe limb damage.

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13
Q

When is a muscle known as a skeletal muscle?

A

When at least one end is connected to a bone through a tendon.

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14
Q

Where are smooth muscles found?

A

Around blood vessels, glands, the gut, and the bronchioles.

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15
Q

What are skeletal muscles made of?

A

They are composed of bands of the proteins actin (thin) and myosin (thick).

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16
Q

What is the name given to the basic unit of striated muscle tissue

A

A sacromere

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17
Q

What initiates voluntary muscle contractions?

A

Nerve impulses that start in the brain of spinal coloumn.

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18
Q

Where do nerve impulses travel to initiate muscle contractions?

A

Through the somatic division of the peripheral nerve system.

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19
Q

What is a motor neurone vs motor unit?

A

A motor neurone will control several muscle fibres, whilst a motor uni consist of the motor neurone and the fibres it controls.

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20
Q

What is curare toxin?

A

This blocks the acetylcholine receptor in muscle tissue. The muscle can then no longer respond to a motor nerve stimulus and there is no contraction of muscle fibre.

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21
Q

What is myasthenia gravis?

A

This is an abnormality of acetylcholine receptors, causing those with it to be very weak as they can only activate a few of the fibres in a muscle.

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22
Q

How do we make a movement?

A

Action potential travels to a lower motor neurone, which leads to a single twitch.
A train of action potentials spaced apart will lead to multiple twitches.
If action potentials arrive within 10-100ms of each other than they build up and give rise to large muscle contractions known as tetanic contractions.

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23
Q

What does the strength of a muscle contraction rely on?

A

How many motor neurones and muscle fibres are activated at approximately the same time, which is known as recruitment.

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24
Q

What can damage lower motor neurones?

A

A motor neurone disease, a trauma where a peripheral nerve is cut, by polio, or by alcohol.

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25
Q

What are symptoms of lower motor neurone syndrome?

A

Paralysis
Muscle wasting
Fatigue
No reflexes

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26
Q

Which neurones talk to lower motor neurones?

A

Upper motor neurones (voluntary)
Sensory neurones (Reflex)
Neurones that control posture (normally involuntary)

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27
Q

How are motor and sensory strips in the brain organised?

A

Somatotropically

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28
Q

What happens in premotor areas?

A

More abstract planning

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29
Q

What occurs in the primary motor cortex?

A

Executes all voluntary movements in the body, the ‘doing’ area.

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30
Q

What occurs in the posterior parietal cortex?

A

A ‘planning’ area - involved in spatial reasoning and attention

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31
Q

What occurs in the premotor cortex?

A

An ‘intention’ area - links action with visual objects and selects sequences of appropriate movements.

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32
Q

What occurs in the supplementary motor cortex?

A

Stores info on well learned actions

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33
Q

What are ‘Jacksonian March’ seizures?

A

A condition that leads to abnormal motor movements that begin in a restricted region then progress over extremities.

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34
Q

What did Mushiake (1991) find with regards to improvements in action?

A

After prior training participants performed better in a task and showed greater activity in the supplementary motor area.

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35
Q

What is apraxia?

A

An inability to carry out movements in response to commands.
It’s caused by damage to the posterior cortex and causes difficulty in motor planning.

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36
Q

What did Libet (1985) find with regards to action potentials?

A

They start building before the participant actually became aware of their intention

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37
Q

Who completed research with regards to prosthetic limbs?

A

Hochberg (2012)

38
Q

What did Roitman and Shadlen (2002) and Gold and Shadlen (2004) find with regards to monkeys and brain activation?

A

Monkeys show a build up of graded activation when following moving dots, and activation occurred jut when the frontal eye fields were stimulated. Exposure to a stimulus increase change of eye movement in monkeys.

39
Q

Which area is involved with hand movements?

A

Supplementary motor area

40
Q

What ha been found with regards to motivation and movement?

A

Participants are more likely to do movements that they find rewarding, with more activation in motor areas that correspond to the rewarding movement.

41
Q

Which areas are involved in reaching for objects?

A

The parieto-occipital extra-striate area and the dorsal promotor area.

42
Q

Which areas are involved in grasping objects?

A

Dorsal extra-striate cortex and ventral premotor area.

43
Q

Which cortex helps sensory motor coordination?

A

Parietal cortex, as parietal cells represent locations of visual stimuli.

44
Q

What is the supplementary motor area essential for?

A

Generating linked self-generated movements.

45
Q

What did Tanji and Shima (1994) find with regards to the supplementary motor area?

A

Deactivation produces severe disruption of learned sequences.

46
Q

Where is the cerebellum located?

What does it do?

A

Above the brainstem towards the back of the brain.

It is involved in coordination, balance and rapid movements.

47
Q

What are ballisitc movements?

A

These are rapid movements that occur so rapidly one cannot depend on sensory feedback for control.
EG: Running, typing, writing, talking

48
Q

What happens when we are exposed to errors?

A

Vestibular receptors send signals to the vestibulo-cerebellum, which initiates correct signals. The vestibular nuclei then adjusts necessary muscles.

49
Q

How are motor and cognitive error correction different?

A

Motor involves the motor cortex, spinal cord, and muscular-skeletal system. It produces motor output and sensory consequence.

Cognitive involves the prefrontal cortex which produces an informative output and cognitive consequences.

50
Q

What is cerebella ataxia?

A

Errors in range and direction of movement. Uncontrolled eye movements and slurred speech.

51
Q

What is Disdiadocho Kinesia?

A

An impaired ability to perform rapid alternating movements

52
Q

What are hypometria and response delays?

A

Responses are delayed and often fall short of the intended goal

53
Q

What is the main role of the basal ganglia?

A

Action selection, influenced by decisions in the prefrontal cortex.

54
Q

What is hypokinesia vs hyperkinesia?

A

Hypo - Insufficient direct pathway output, with an excess of an indirect pathway output
Hyper - Insufficient indirect pathway output, with an excess of an direct pathway output

55
Q

What is the direct pathway to movement?

A

Cortex stimulates the striatum > Inhibits Nr and Gpi > Less inhibition of the thalamus > Cortex is stimulated more> Spinal tract stimulated via upper motor neurones to lower motor neurones > movement.

56
Q

What is the indirect pathway to movement?

A

Cortex stimulates the striatum > Inhibits Gpe > Less inhibition of STN > Stimulates the SNr - Gpi complex > inhibits the thalamus > less stimulation of cortex > less stimulation of neurones leading to less movement.

57
Q

What are the effects of lobotomies?

A
A general impairment of higher mental functions
Judgement
Future Planning
Social Awareness
Creativity
Emotional relatability 
Dull and apathetic
58
Q

What do we use executive control for?

A
Planning
Time Management 
Sustained attention
Working memory
Task switching
Goal Orientation
Inhibition
Organisation
59
Q

What did Bianchi find with regards to frontal cortex damage?

A

It led to problems such as an inability to use past experience to guide behaviour and a general lack of coherence.

60
Q

What is inhibition used for in prefrontal control?

A

To overcome automatic processes

61
Q

What is initiation/task-switching used for in prefrontal control?

A

To facilitate selection of new behaviour

62
Q

What are simulation and rehearsal used for in prefrontal control?

A

Being mindful of outcomes, judging behaviours

63
Q

What are the four types of inhibition?

A

Restraining potentiated behaviour
Preventing information from interfering with processing
Restraining inappropriate actions
Removing irrelevant info from working memory.

64
Q

What did Schreuder (2017) find with regards to iniation?

A

A spike in prefrontal activity was seen 300ms arfter participants spotted a ball of a target colour, so this is known as a P300 spike.

65
Q

What is the orbitofrontal cortex important for?

A

It is a part of the vmPFC, with the lateral part of the OFC important for establishing links between stimuli and actions. It is critical for adaptive learning.

66
Q

What can damage to the OFC cause?

A

Impairments in the ability to interact with objects and others. It can lead to acquired sociopathy, so they are unconcerned about punishment or consequences.

67
Q

What can damage to the medial PFC cause?

A

Impairs the need for goals and the ability to initiate actions. Patients become lethargic and quiet and cannot sustain movement

68
Q

What can be used to test cognitive flexibility in infants?

A

The looking in A not B cup test. They start to pass around the age of one.

69
Q

What is the Wisconsin Card Switching task used to test?

A

Task switching, abstract reasoning, and problem solving.

70
Q

What causes involuntary imitative behaviour?

A

Dysfunction in the frontal lobe

71
Q

What is utiity?

A

This can be a measure of reward, based on a psychological value rather than an objective one.

72
Q

What is diminished utility?

A

When a reward does not have much relative value.

73
Q

What do normative theories claim with regards to rewards?

A

That people take risks based on the concept of probability and expected value.

74
Q

What does prospect theory claim with regards to rewards?

A

Decision making is made based on judgements that already exist.

75
Q

What is anchoring?

A

When you judge relative value based on the first piece of information you receive.

76
Q

What are primary and secondary reinforcers?

A

Primary - Water, food, sex, pleasure

Secondary - When this can be used to gain other rewards, so it has no actual value itself. For example, money.

77
Q

What is dopamine important for and what is it associated with?

A

Motivation, exploring, habits, learning

Reward seeking behaviours and addiction

78
Q

Where is dopamine produced?

A

The substantia nigra.

79
Q

What are the two routes for the production of dopamine found in the VTA?

A

Mesolimbic: The amygdala and hippocampus
Neocortical: All of the cortex but especially the medial parts of the frontal lobe.

80
Q

What was found with regards to rats and the release of dopamine?

A

When stimulating the VTA via pressing a lever there was not the same amount of dopamine release compared to when the VTA is unexpectedly stimulated.

81
Q

What does mentalising refer to?

A

Representing the feelings and thoughts of others as if they were your own

82
Q

What are the main symptoms of Parkinson’s?

A

Dyskinesia: abnormality of voluntary movement
Akinesia: absence of movements
Hypoekinesia: slowness of movements

83
Q

Which areas are affected in Parkinson’s?

A

The basal ganglia, and areas with many dopaminergic neurons.
The nigro-striatal pathway damage leads to a depletion of striatal dopamine.

84
Q

What is hemisballimus?

A

A movement disorder characterised by dance like movements. It features hyperkinetic movements - patients cannot stop them.

85
Q

What cause hemisballimus?

A

A decreased activity in the sub-thalamic nucleus of the basal ganglia due to stroke or brain injury.

86
Q

What is tourettes?

A

This is characterised by motor tics, typically preceded by an unwanted urge or sensation in the affected muscle.

87
Q

Which brain areas are affected in tourettes?

A

The basal ganglia is thought to be involved since it involves movement, as well as connection failures in the cortex.

88
Q

What can abnormal dopamine levels cause?

A

Impulse control disorders such as over eating, shopping addiction and hyper sexual activity.

89
Q

Is there treatment for dopamine abnormalities?

A

L-DOPA enters the brain through the blood and is converted into dopamine. However, this may cause severe side effects.

90
Q

What does deep brain stimulation do?

A

Stimulation is applied to the sub-thalamic nucleus. It improves slowness of movements and tremors. However, it can cause side effects such as hallucinations and depression, as well as potential personality changes.