TB treatment

Question 1

Cornerstone of TB treatment?

Answer 1

isoniazid and rifampin

Question 2

first line core drug for TB treament?

Answer 2

isoniazid

Question 3

Isoniazid is ______ against _____, and ______ against _______

Answer 3

bacteriocidal-actively growig TB, bacteriostatic against non-replicating organisms

Question 4

Isoniazid works by:

Answer 4

inhibits mycolic acid synth (mycobacterial cell wall) and inhibits cat peroxidase

Question 5

problem with isoniazid?

Answer 5

resistance is common in monotherapy

Question 6

isoniazid is used for:

Answer 6

tb treatment of latent tb (pos test without overt disease) and prevention

Question 7

isonaizid is used:

Answer 7

once daily oral

Question 8

isonaizid is metabolised?

Answer 8

in liver by n-acetyltransferase and metabolites secreted in urine

Question 9

isonaizid adverse reaction?

Answer 9

hepatitis (more common with increased age), 15% asymptomatic LFT elevation

Question 10

rifampin is part of:

Answer 10

first line core drug, cornerstone of therapy with isonaizid

Question 11

rif is bacteriocidal against:

Answer 11

actively growing (intra and extra) less so against nonreplicating organisms

Question 12

rif works by:

Answer 12

inhibits bacterial dna-dependent rna poly

Question 13

prob with rif?

Answer 13

resistance